PUBLICATION

Zebrafish Infection: From Pathogenesis to Cell Biology

Authors
Torraca, V., Mostowy, S.
ID
ZDB-PUB-171128-8
Date
2017
Source
Trends in cell biology   28(2): 143-156 (Review)
Registered Authors
Mostowy, Serge, Torraca, Vincenzo
Keywords
autophagy, bacterial infection, cellular microbiology, inflammation, innate immunity, zebrafish
MeSH Terms
  • Animals
  • Animals, Genetically Modified
  • Cytological Techniques/methods
  • Disease Models, Animal*
  • Host-Pathogen Interactions/physiology*
  • Humans
  • Immunity, Innate/physiology
  • Larva/cytology*
  • Larva/physiology*
  • Larva/ultrastructure
  • Neutrophils/physiology
  • Zebrafish/genetics*
  • Zebrafish/growth & development
  • Zebrafish/immunology*
PubMed
29173800 Full text @ Trends Cell Biol.
Abstract
The study of host-pathogen interactions has illuminated fundamental research avenues in both infection and cell biology. Zebrafish (Danio rerio) larvae are genetically tractable, optically accessible, and present a fully functional innate immune system with macrophages and neutrophils that mimic their mammalian counterparts. A wide variety of pathogenic bacteria have been investigated using zebrafish models, providing unprecedented resolution of the cellular response to infection in vivo. In this review, we illustrate how zebrafish models have contributed to our understanding of cellular microbiology by providing an in vivo platform to study host-pathogen interactions from the single cell to whole animal level. We also highlight discoveries made from zebrafish infection that hold great promise for translation into novel therapies for humans.
Genes / Markers
Figures
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Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping