PUBLICATION
Zebrafish heart regeneration: 15 years of discoveries
- Authors
- González-Rosa, J.M., Burns, C.E., Burns, C.G.
- ID
- ZDB-PUB-171006-6
- Date
- 2017
- Source
- Regeneration (Oxford, England) 4: 105-123 (Review)
- Registered Authors
- Burns (Erter), Caroline, Burns, Geoff, Gonzalez-Rosa, Juan Manuel
- Keywords
- cardiomyocyte proliferation, heart regeneration, myocardial infarction, zebrafish
- MeSH Terms
- none
- PubMed
- 28979788 Full text @ Regeneration (Oxf)
Citation
González-Rosa, J.M., Burns, C.E., Burns, C.G. (2017) Zebrafish heart regeneration: 15 years of discoveries. Regeneration (Oxford, England). 4:105-123.
Abstract
Cardiovascular disease is the leading cause of death worldwide. Compared to other organs such as the liver, the adult human heart lacks the capacity to regenerate on a macroscopic scale after injury. As a result, myocardial infarctions are responsible for approximately half of all cardiovascular related deaths. In contrast, the zebrafish heart regenerates efficiently upon injury through robust myocardial proliferation. Therefore, deciphering the mechanisms that underlie the zebrafish heart's endogenous regenerative capacity represents an exciting avenue to identify novel therapeutic strategies for inducing regeneration of the human heart. This review provides a historical overview of adult zebrafish heart regeneration. We summarize 15 years of research, with a special focus on recent developments from this fascinating field. We discuss experimental findings that address fundamental questions of regeneration research. What is the origin of regenerated muscle? How is regeneration controlled from a genetic and molecular perspective? How do different cell types interact to achieve organ regeneration? Understanding natural models of heart regeneration will bring us closer to answering the ultimate question: how can we stimulate myocardial regeneration in humans?
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping