PUBLICATION
Expression and regulation of drug transporters in vertebrate neutrophils
- Authors
- Foulkes, M.J., Henry, K.M., Rougeot, J., Hooper-Greenhill, E., Loynes, C.A., Jeffrey, P., Fleming, A., Savage, C.O., Meijer, A.H., Jones, S., Renshaw, S.A.
- ID
- ZDB-PUB-170712-10
- Date
- 2017
- Source
- Scientific Reports 7: 4967 (Journal)
- Registered Authors
- Fleming, Angeleen, Henry, Katherine, Loynes, Catherine, Meijer, Annemarie H., Renshaw, Steve A., Rougeot, Julien
- Keywords
- Neutrophils, Transporters
- Datasets
- GEO:GSE78954
- MeSH Terms
-
- ATP-Binding Cassette Transporters/genetics*
- ATP-Binding Cassette Transporters/metabolism
- Animals
- Evolution, Molecular
- Gene Expression Regulation
- Humans
- Molecular Sequence Annotation
- Multigene Family
- Neutrophils/metabolism*
- Phylogeny
- Sequence Analysis, RNA/methods*
- Solute Carrier Proteins/genetics*
- Solute Carrier Proteins/metabolism
- Zebrafish/genetics
- Zebrafish/metabolism*
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- PubMed
- 28694436 Full text @ Sci. Rep.
Citation
Foulkes, M.J., Henry, K.M., Rougeot, J., Hooper-Greenhill, E., Loynes, C.A., Jeffrey, P., Fleming, A., Savage, C.O., Meijer, A.H., Jones, S., Renshaw, S.A. (2017) Expression and regulation of drug transporters in vertebrate neutrophils. Scientific Reports. 7:4967.
Abstract
There remains a need to identify novel pro-resolution drugs for treatment of inflammatory disease. To date, there are no neutrophil-specific anti-inflammatory treatments in clinical use, perhaps due to our lack of understanding of how drugs access this complex cell type. Here we present the first comprehensive description and expression of both major classes of drug transporters, SLC and ABC, in resting human blood neutrophils. Moreover, we have studied the expression of these carriers in the tractable model system, the zebrafish (Danio rerio), additionally examining the evolutionary relationship between drug transporters in zebrafish and humans. We anticipate that this will be a valuable resource to the field of inflammation biology and will be an important asset in future anti-inflammatory drug design.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping