ZFIN Person: Loynes, Catherine

ZFIN ID: ZDB-PERS-080925-1

Loynes, Catherine

Email:	c.loynes@sheffield.ac.uk
URL:
Affiliation:	Renshaw Sheffield Lab
Address:	Renshaw Laboratory, D18 MRC Centre for Developmental and Biomedical Genetics Firth Court Western Bank Sheffield, S10 2TN United Kingdom
Country:	United Kingdom
Phone:
Fax:
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Jubber, I., Morhardt, D.R., Griffin, J., Cumberbatch, M., Glover, M., Zheng, Y., Rehman, I., Loynes, C., Hussain, S.A., Renshaw, S.A., Leach, S.D., Cunliffe, V.T., Catto, J.W.F. (2023) Analysis of the distal urinary tract in larval and adult zebrafish reveals homology to the human system. Disease models & mechanisms. 16(7):

Morsli, S., Henriques, C.M., Ellis, P.S., Mortiboys, H., Baxendale, S., Loynes, C.A., Renshaw, S.A., Bellantuono, I. (2023) A p21-GFP zebrafish model of senescence for rapid testing of senolytics in vivo. Aging Cell. 22(6):e13835

Isles, H.M., Loynes, C.A., Alasmari, S., Kon, F.C., Henry, K.M., Kadochnikova, A., Hales, J., Muir, C.F., Keightley, M.C., Kadirkamanathan, V., Hamilton, N., Lieschke, G.J., Renshaw, S.A., Elks, P.M. (2021) Pioneer neutrophils release chromatin within in vivo swarms. eLIFE. 10:

Bernut, A., Loynes, C.A., Floto, R.A., Renshaw, S.A. (2020) Deletion of cftr Leads to an Excessive Neutrophilic Response and Defective Tissue Repair in a Zebrafish Model of Sterile Inflammation. Frontiers in immunology. 11:1733

Plant, T., Eamsamarng, S., Sanchez-Garcia, M.A., Reyes, L., Renshaw, S.A., Coelho, P., Mirchandani, A.S., Morgan, J.M., Ellett, F.E., Morrison, T., Humphries, D., Watts, E.R., Murphy, F., Raffo-Iraolagoitia, X.L., Zhang, A., Cash, J.L., Loynes, C., Elks, P.M., Van Eeden, F., Carlin, L.M., Furley, A.J.W., Whyte, M.K.B., Walmsley, S.R. (2020) Semaphorin 3F signaling actively retains neutrophils at sites of inflammation. The Journal of Clinical Investigation. 130(6):3221-3237

Isles, H.M., Herman, K.D., Robertson, A.L., Loynes, C.A., Prince, L.R., Elks, P.M., Renshaw, S.A. (2019) The CXCL12/CXCR4 Signaling Axis Retains Neutrophils at Inflammatory Sites in Zebrafish. Frontiers in immunology. 10:1784

Evans, R.J., Pline, K., Loynes, C.A., Needs, S., Aldrovandi, M., Tiefenbach, J., Bielska, E., Rubino, R.E., Nicol, C.J., May, R.C., Krause, H.M., O'Donnell, V.B., Renshaw, S.A., Johnston, S.A. (2019) 15-keto-prostaglandin E2 activates host peroxisome proliferator-activated receptor gamma (PPAR-γ) to promote Cryptococcus neoformans growth during infection. PLoS pathogens. 15:e1007597

Loynes, C.A., Lee, J.A., Robertson, A.L., Steel, M.J., Ellett, F., Feng, Y., Levy, B.D., Whyte, M.K.B., Renshaw, S.A. (2018) PGE₂ production at sites of tissue injury promotes an anti-inflammatory neutrophil phenotype and determines the outcome of inflammation resolution in vivo.. Science advances. 4:eaar8320

Foulkes, M.J., Henry, K.M., Rougeot, J., Hooper-Greenhill, E., Loynes, C.A., Jeffrey, P., Fleming, A., Savage, C.O., Meijer, A.H., Jones, S., Renshaw, S.A. (2017) Expression and regulation of drug transporters in vertebrate neutrophils. Scientific Reports. 7:4967

Robertson, A.L., Ogryzko, N.V., Henry, K.M., Loynes, C.A., Foulkes, M.J., Meloni, M.M., Wang, X., Ford, C., Jackson, M., Ingham, P.W., Wilson, H.L., Farrow, S.N., Solari, R., Flower, R.J., Jones, S., Whyte, M.K., Renshaw, S.A. (2016) Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen. Disease models & mechanisms. 9(6):621-32

Hepburn, L., Prajsnar, T.K., Klapholz, C., Moreno, P., Loynes, C.A., Ogryzko, N.V., Brown, K., Schiebler, M., Hegyi, K., Antrobus, R., Hammond, K.L., Connolly, J., Ochoa, B., Bryant, C., Otto, M., Surewaard, B., Seneviratne, S.L., Grogono, D.M., Cachat, J., Ny, T., Kaser, A., Török, M.E., Peacock, S.J., Holden, M., Blundell, T., Wang, L., Ligoxygakis, P., Minichiello, L., Woods, C.G., Foster, S.J., Renshaw, S.A., Floto, R.A. (2014) Innate immunity. A Spaetzle-like role for nerve growth factor β in vertebrate immunity to Staphylococcus aureus. Science (New York, N.Y.). 346:641-6

Robertson, A.L., Holmes, G.R., Bojarczuk, A.N., Burgon, J., Loynes, C.A., Chimen, M., Sawtell, A.K., Hamza, B., Willson, J., Walmsley, S.R., Anderson, S.R., Coles, M.C., Farrow, S.N., Solari, R., Jones, S., Prince, L.R., Irimia, D., Rainger, G.E., Kadirkamanathan, V., Whyte, M.K., Renshaw, S.A. (2014) A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism. Science Translational Medicine. 6:225ra29

Henry, K.M., Loynes, C.A., Whyte, M.K., and Renshaw, S.A. (2013) Zebrafish as a model for the study of neutrophil biology. Journal of Leukocyte Biology. 94(4):633-642

Dixon, G., Elks, P.M., Loynes, C.A., Whyte, M.K., and Renshaw, S.A. (2012) A Method for the In Vivo Measurement of Zebrafish Tissue Neutrophil Lifespan. ISRN Hematology. 2012:915868

Gray, C., Loynes, C.A., Whyte, M.K., Crossman, D.C., Renshaw, S.A., and Chico, T.J. (2011) Simultaneous intravital imaging of macrophage and neutrophil behaviour during inflammation using a novel transgenic zebrafish. Thrombosis and haemostasis. 105(5):811-819

Elks, P.M., Loynes, C.A., and Renshaw, S.A. (2011) Measuring Inflammatory Cell Migration in the Zebrafish. Methods in molecular biology (Clifton, N.J.). 769:261-275

Loynes, C.A., Martin, J.S., Robertson, A., Trushell, D.M., Ingham, P.W., Whyte, M.K., and Renshaw, S.A. (2010) Pivotal Advance: Pharmacological manipulation of inflammation resolution during spontaneously resolving tissue neutrophilia in the zebrafish. Journal of Leukocyte Biology. 87(2):203-212

NON-ZEBRAFISH PUBLICATIONS