PUBLICATION
Utilizing Zebrafish Visual Behaviors in Drug Screening for Retinal Degeneration
- Authors
- Ganzen, L., Venkatraman, P., Pang, C.P., Leung, Y.F., Zhang, M.
- ID
- ZDB-PUB-170603-6
- Date
- 2017
- Source
- International Journal of Molecular Sciences 18(6): 1185 (Review)
- Registered Authors
- Ganzen, Logan, Leung, Yuk Fai, Venkatraman, Prahatha
- Keywords
- drug screening, night blindness, retinal degeneration, retinitis pigmentosa, visual behaviors, visual motor response, zebrafish
- MeSH Terms
-
- Animals
- Disease Models, Animal
- Drug Evaluation, Preclinical/methods*
- Retina/drug effects*
- Retina/pathology
- Retinal Degeneration/drug therapy*
- Retinal Degeneration/pathology
- Vision, Ocular/drug effects
- Zebrafish/physiology*
- PubMed
- 28574477 Full text @ Int. J. Mol. Sci.
Citation
Ganzen, L., Venkatraman, P., Pang, C.P., Leung, Y.F., Zhang, M. (2017) Utilizing Zebrafish Visual Behaviors in Drug Screening for Retinal Degeneration. International Journal of Molecular Sciences. 18(6):1185.
Abstract
Zebrafish are a popular vertebrate model in drug discovery. They produce a large number of small and rapidly-developing embryos. These embryos display rich visual-behaviors that can be used to screen drugs for treating retinal degeneration (RD). RD comprises blinding diseases such as Retinitis Pigmentosa, which affects 1 in 4000 people. This disease has no definitive cure, emphasizing an urgency to identify new drugs. In this review, we will discuss advantages, challenges, and research developments in using zebrafish behaviors to screen drugs in vivo. We will specifically discuss a visual-motor response that can potentially expedite discovery of new RD drugs.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping