PUBLICATION
Caffeic acid and hydroxytyrosol have anti-obesogenic properties in zebrafish and rainbow trout models
- Authors
- Lutfi, E., Babin, P.J., Gutiérrez, J., Capilla, E., Navarro, I.
- ID
- ZDB-PUB-170602-4
- Date
- 2017
- Source
- PLoS One 12: e0178833 (Journal)
- Registered Authors
- Babin, Patrick J.
- Keywords
- none
- MeSH Terms
-
- Animals
- Anti-Obesity Agents/pharmacology*
- Caffeic Acids/pharmacology*
- Models, Biological*
- Obesity/drug therapy*
- Oncorhynchus mykiss
- PPAR gamma/agonists
- PPAR gamma/metabolism
- Phenylethyl Alcohol/analogs & derivatives*
- Phenylethyl Alcohol/pharmacology
- Signal Transduction
- Thiazolidinediones/pharmacology
- Zebrafish
- PubMed
- 28570659 Full text @ PLoS One
Citation
Lutfi, E., Babin, P.J., Gutiérrez, J., Capilla, E., Navarro, I. (2017) Caffeic acid and hydroxytyrosol have anti-obesogenic properties in zebrafish and rainbow trout models. PLoS One. 12:e0178833.
Abstract
Some natural products, known sources of bioactive compounds with a wide range of properties, may have therapeutic values in human health and diseases, as well as agronomic applications. The effect of three compounds of plant origin with well-known dietary antioxidant properties, astaxanthin (ATX), caffeic acid (CA) and hydroxytyrosol (HT), on zebrafish (Danio rerio) larval adiposity and rainbow trout (Onchorynchus mykiss) adipocytes was assessed. The zebrafish obesogenic test (ZOT) demonstrated the anti-obesogenic activity of CA and HT. These compounds were able to counteract the obesogenic effect produced by the peroxisome proliferator-activated receptor gamma (PPARγ) agonist, rosiglitazone (RGZ). CA and HT suppressed RGZ-increased PPARγ protein expression and lipid accumulation in primary-cultured rainbow trout adipocytes. HT also significantly reduced plasma triacylglycerol concentrations, as well as mRNA levels of the fasn adipogenic gene in the adipose tissue of HT-injected rainbow trout. In conclusion, in vitro and in vivo approaches demonstrated the anti-obesogenic potential of CA and HT on teleost fish models that may be relevant for studying their molecular mode of action. Further studies are required to evaluate the effect of these bioactive components as food supplements for modulating adiposity in farmed fish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping