ZFIN ID: ZDB-PUB-170326-15
Modeling Syndromic Congenital Heart Defects in Zebrafish
Grant, M.G., Patterson, V.L., Grimes, D.T., Burdine, R.D.
Date: 2017
Source: Current topics in developmental biology   124: 1-40 (Chapter)
Registered Authors: Burdine, Rebecca, Grimes, Daniel T.
Keywords: Cardiac asymmetry, Cardiac neural crest, Congenital heart defects, Endocardium, Myocardium, Secondary heart field, Valvulogenesis, Zebrafish
MeSH Terms:
  • Animals
  • Disease Models, Animal*
  • Heart/embryology
  • Heart Defects, Congenital/pathology*
  • Humans
  • Models, Biological
  • Syndrome
  • Zebrafish/physiology*
PubMed: 28335857 Full text @ Curr. Top. Dev. Biol.
Cardiac development is a dynamic process regulated by spatial and temporal cues that are integrated to effect molecular, cellular, and tissue-level events that form the adult heart. Disruption of these highly orchestrated events can be devastating for cardiac form and function. Aberrations in heart development result in congenital heart defects (CHDs), which affect 1 in 100 infants in the United States each year. Zebrafish have proven informative as a model organism to understand both heart development and the mechanisms associated with CHDs due to the similarities in heart morphogenesis among vertebrates, as well as their genetic tractability and amenability to live imaging. In this review, we discuss the mechanisms of zebrafish heart development and the utility of zebrafish for understanding syndromic CHDs, those cardiac abnormalities that occur in the context of multisystem disorders. We conclude with avenues of zebrafish research that will potentially inform future therapeutic approaches for the treatment of CHDs.