ZFIN Person: Burdine, Rebecca

ZFIN ID: ZDB-PERS-980430-1

ZFIN ID: ZDB-PERS-980430-1

Burdine, Rebecca

Email:	rburdine@princeton.edu
URL:	https://burdinelab.scholar.princeton.edu/
Affiliation:	Burdine Lab
Address:	Department of Molecular Biology Moffett Lab 159 Princeton University Washington Road Princeton, NJ 08544-1014 USA
Country:	United States
Phone:	(609) 258-7515
Fax:
ORCID ID:	0000-0001-6620-5015

BIOGRAPHY AND RESEARCH INTERESTS

PhD - Yale University, 1997
B.S. - Western Kentucky University, 1990

2003-present Professor
Princeton University
Department of Molecular Biology

1998-2002 Postdoctoral Research
Dr. Alexander F. Schier, advisor
Developmental Genetics Program, Skirball Institute of Biomolecular Medicine NYU

1994-1998 Graduate Research, Postdoctoral Research
Dr. Michael J. Stern, thesis advisor
Department of Genetics, Yale University School of Medicine

PUBLICATIONS

Patterson, V., Ullah, F., Bryant, L., Griffin, J.N., Sidhu, A., Saliganan, S., Blaile, M., Saenz, M.S., Smith, R., Ellingwood, S., Grange, D.K., Hu, X., Mireguli, M., Luo, Y., Shen, Y., Mulhern, M., Zackai, E., Ritter, A., Izumi, K., Hoefele, J., Wagner, M., Riedhammer, K.M., Seitz, B., Robin, N.H., Goodloe, D., Mignot, C., Keren, B., Cox, H., Jarvis, J., Hempel, M., Gibson, C.F., Tran Mau-Them, F., Vitobello, A., Bruel, A.L., Sorlin, A., Mehta, S., Raymond, F.L., Gilmore, K., Powell, B.C., Weck, K., Li, C., Vulto-van Silfhout, A.T., Giacomini, T., Mancardi, M.M., Accogli, A., Salpietro, V., Zara, F., Vora, N.L., Davis, E.E., Burdine, R., Bhoj, E. (2023) Erratum for the Research Article: "Abrogation of MAP4K4 protein function causes congenital anomalies in humans and zebrafish". Science advances. 9:eadl5515eadl5515

Patterson, V., Ullah, F., Bryant, L., Dong, L.I., Griffin, J.N., Sidhu, A., Saliganan, S., Blaile, M., Saenz, M.S., Smith, R., Ellingwood, S., Grange, D.K., Hu, X., Mireguli, M., Luo, Y., Shen, Y., Mulhern, M., Zackai, E., Ritter, A., Izumi, K., Hoefele, J., Wagner, M., Riedhammer, K.M., Seitz, B., Robin, N.H., Goodloe, D., Mignot, C., Keren, B., Cox, H., Jarvis, J., Hempel, M., Gibson, C.F., Tran Mau-Them, F., Vitobello, A., Bruel, A.L., Sorlin, A., Mehta, S., Raymond, F.L., Gilmore, K., Powell, B.C., Weck, K., Li, C., Vulto-van Silfhout, A.T., Giacomini, T., Mancardi, M.M., Accogli, A., Salpietro, V., Zara, F., Vora, N.L., Davis, E.E., Burdine, R.D., Bhoj, E. (2023) Abrogation of MAP4K4 protein function causes congenital anomalies in humans and zebrafish. Science advances. 9:eade0631eade0631

Maerker, M., Getwan, M., Dowdle, M.E., McSheene, J.C., Gonzalez, V., Pelliccia, J.L., Hamilton, D.S., Yartseva, V., Vejnar, C., Tingler, M., Minegishi, K., Vick, P., Giraldez, A.J., Hamada, H., Burdine, R.D., Sheets, M.D., Blum, M., Schweickert, A. (2021) Bicc1 and Dicer regulate left-right patterning through post-transcriptional control of the Nodal inhibitor Dand5. Nature communications. 12:5482

Patterson, V.L., Burdine, R.D. (2020) Swimming toward solutions: Using fish and frogs as models for understanding RASopathies. Birth defects research. 112(10):749-765

Patel, A.L., Yeung, E., McGuire, S.E., Wu, A.Y., Toettcher, J.E., Burdine, R.D., Shvartsman, S.Y. (2019) Optimizing photoswitchable MEK. Proceedings of the National Academy of Sciences of the United States of America. 116(51):25756-25763

Grimes, D.T., Patterson, V.L., Luna-Arvizu, G., Schottenfeld-Roames, J., Irons, Z.H., Burdine, R.D. (2019) Left-right asymmetric heart jogging increases the robustness of dextral heart looping in zebrafish. Developmental Biology. 459(2):79-86

Harris, A., Siggers, P., Corrochano, S., Warr, N., Sagar, D., Grimes, D.T., Suzuki, M., Burdine, R.D., Cong, F., Koo, B.K., Clevers, H., Stévant, I., Nef, S., Wells, S., Brauner, R., Ben Rhouma, B., Belguith, N., Eozenou, C., Bignon-Topalovic, J., Bashamboo, A., McElreavey, K., Greenfield, A. (2018) ZNRF3 functions in mammalian sex determination by inhibiting canonical WNT signaling. Proceedings of the National Academy of Sciences of the United States of America. 115(21):5474-5479

Pelliccia, J.L., Jindal, G.A., Burdine, R.D. (2017) Gdf3 is required for robust Nodal signaling during germ layer formation and left-right patterning. eLIFE. 6

Stainier, D.Y.R., Raz, E., Lawson, N.D., Ekker, S.C., Burdine, R.D., Eisen, J.S., Ingham, P.W., Schulte-Merker, S., Yelon, D., Weinstein, B.M., Mullins, M.C., Wilson, S.W., Ramakrishnan, L., Amacher, S.L., Neuhauss, S.C.F., Meng, A., Mochizuki, N., Panula, P., Moens, C.B. (2017) Guidelines for morpholino use in zebrafish. PLoS Genetics. 13:e1007000

Jindal, G.A., Goyal, Y., Humphreys, J.M., Yeung, E., Tian, K., Patterson, V.L., He, H., Burdine, R.D., Shvartsman, S.Y., Goldsmith, E.J. (2017) How activating mutations affect MEK1 regulation and function. The Journal of biological chemistry. 292(46):18814-18820

Goyal, Y., Jindal, G.A., Pelliccia, J.L., Yamaya, K., Yeung, E., Futran, A.S., Burdine, R.D., Schüpbach, T., Shvartsman, S.Y. (2017) Divergent effects of intrinsically active MEK variants on developmental Ras signaling. Nature Genetics. 49(3):465-469

Jindal, G.A., Goyal, Y., Yamaya, K., Futran, A.S., Kountouridis, I., Balgobin, C.A., Schüpbach, T., Burdine, R.D., Shvartsman, S.Y. (2017) In vivo severity ranking of Ras pathway mutations associated with developmental disorders. Proceedings of the National Academy of Sciences of the United States of America. 114(3):510-515

Grant, M.G., Patterson, V.L., Grimes, D.T., Burdine, R.D. (2017) Modeling Syndromic Congenital Heart Defects in Zebrafish. Current topics in developmental biology. 124:1-40

Burdine, R.D., Grimes, D.T. (2016) Antagonistic interactions in the zebrafish midline prior to the emergence of asymmetric gene expression are important for left-right patterning. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 371(1710)

Grimes, D.T., Boswell, C.W., Morante, N.F., Henkelman, R.M., Burdine, R.D., Ciruna, B. (2016) Zebrafish models of idiopathic scoliosis link cerebrospinal fluid flow defects to spine curvature. Science (New York, N.Y.). 352:1341-4

Jaffe, K.M., Grimes, D.T., Schottenfeld-Roames, J., Werner, M.E., Ku, T.J., Kim, S.K., Pelliccia, J.L., Morante, N.F., Mitchell, B.J., Burdine, R.D. (2016) c21orf59/kurly Controls Both Cilia Motility and Polarization. Cell Reports. 14(8):1841-9

Jindal, G.A., Goyal, Y., Burdine, R.D., Rauen, K.A., Shvartsman, S.Y. (2015) RASopathies: unraveling mechanisms with animal models. Disease models & mechanisms. 8:769-82

Kim, C.K., Miri, A., Leung, L.C., Berndt, A., Mourrain, P., Tank, D.W., Burdine, R.D. (2014) Prolonged, brain-wide expression of nuclear-localized GCaMP3 for functional circuit mapping. Frontiers in neural circuits. 8:138

Hjeij, R., Onoufriadis, A., Watson, C.M., Slagle, C.E., Klena, N.T., Dougherty, G.W., Kurkowiak, M., Loges, N.T., Diggle, C.P., Morante, N.F., Gabriel, G.C., Lemke, K.L., Li, Y., Pennekamp, P., Menchen, T., Konert, F., Marthin, J.K., Mans, D.A., Letteboer, S.J., Werner, C., Burgoyne, T., Westermann, C., Rutman, A., Carr, I.M., O'Callaghan, C., Moya, E., Chung, E.M., UK10K Consortium, Sheridan, E., Nielsen, K.G., Roepman, R., Bartscherer, K., Burdine, R.D., Lo, C.W., Omran, H., Mitchison, H.M. (2014) CCDC151 Mutations Cause Primary Ciliary Dyskinesia by Disruption of the Outer Dynein Arm Docking Complex Formation. American journal of human genetics. 95:257-274

Tarkar, A., Loges, N.T., Slagle, C.E., Francis, R., Dougherty, G.W., Tamayo, J.V., Shook, B., Cantino, M., Schwartz, D., Jahnke, C., Olbrich, H., Werner, C., Raidt, J., Pennekamp, P., Abouhamed, M., Hjeij, R., Köhler, G., Griese, M., Li, Y., Lemke, K., Klena, N., Liu, X., Gabriel, G., Tobita, K., Jaspers, M., Morgan, L.C., Shapiro, A.J., Letteboer, S.J., Mans, D.A., Carson, J.L., Leigh, M.W., Wolf, W.E., Chen, S., Lucas, J.S., Onoufriadis, A., Plagnol, V., Schmidts, M., Boldt, K., UK10K., Roepman, R., Zariwala, M.A., Lo, C.W., Mitchison, H.M., Knowles, M.R., Burdine, R.D., Loturco, J.J., and Omran, H. (2013) DYX1C1 is required for axonemal dynein assembly and ciliary motility. Nature Genetics. 45(9):995-1003

Lenhart, K.F., Holtzman, N.G., Williams, J.R., and Burdine, R.D. (2013) Integration of Nodal and BMP Signals in the Heart Requires FoxH1 to Create Left-Right Differences in Cell Migration Rates That Direct Cardiac Asymmetry. PLoS Genetics. 9(1):e1003109

Panizzi, J.R., Becker-Heck, A., Castleman, V.H., Al-Mutairi, D.A., Liu, Y., Loges, N.T., Pathak, N., Austin-Tse, C., Sheridan, E., Schmidts, M., Olbrich, H., Werner, C., Häffner, K., Hellman, N., Chodhari, R., Gupta, A., Kramer-Zucker, A., Olale, F., Burdine, R.D., Schier, A.F., O'Callaghan, C., Chung, E.M., Reinhardt, R., Mitchison, H.M., King, S.M., Omran, H., and Drummond, I.A. (2012) CCDC103 mutations cause primary ciliary dyskinesia by disrupting assembly of ciliary dynein arms. Nature Genetics. 44(6):714-719

Lenhart, K.F., Lin, S.Y., Titus, T.A., Postlethwait, J.H., Burdine, R.D. (2011) Two additional midline barriers function with midline lefty1 expression to maintain asymmetric Nodal signaling during left-right axis specification in zebrafish. Development (Cambridge, England). 138(20):4405-4410

Slagle, C.E., Aoki, T., and Burdine, R.D. (2011) Nodal-Dependent Mesendoderm Specification Requires the Combinatorial Activities of FoxH1 and Eomesodermin. PLoS Genetics. 7(5):e1002072

Fogelgren, B., Lin, S.Y., Zuo, X., Jaffe, K.M., Park, K.M., Reichert, R.J., Bell, P.D., Burdine, R.D., and Lipschutz, J.H. (2011) The Exocyst Protein Sec10 Interacts with Polycystin-2 and Knockdown Causes PKD-Phenotypes. PLoS Genetics. 7(4):e1001361

Miri, A., Daie, K., Burdine, R.D., Aksay, E., and Tank, D.W. (2011) Regression-based identification of behavior-encoding neurons during large scale optical imaging of neural activity at cellular resolution. Journal of neurophysiology. 105(2):964-980

Sullivan-Brown, J., Bisher, M.E., and Burdine, R.D. (2011) Embedding, serial sectioning and staining of zebrafish embryos using JB-4 resin. Nature Protocols. 6(1):46-55

Becker-Heck, A., Zohn, I.E., Okabe, N., Pollock, A., Lenhart, K.B., Sullivan-Brown, J., McSheene, J., Loges, N.T., Olbrich, H., Haeffner, K., Fliegauf, M., Horvath, J., Reinhardt, R., Nielsen, K.G., Marthin, J.K., Baktai, G., Anderson, K.V., Geisler, R., Niswander, L., Omran, H., and Burdine, R.D. (2011) The coiled-coil domain containing protein CCDC40 is essential for motile cilia function and left-right axis formation. Nature Genetics. 43(1):79-84

Jaffe, K.M., Thiberge, S.Y., Bisher, M.E., and Burdine, R.D. (2010) Imaging Cilia in Zebrafish. Methods in cell biology. 97C:415-435

Serluca, F.C., Xu, B., Okabe, N., Baker, K., Lin, S.Y., Sullivan-Brown, J., Konieczkowski, D.J., Jaffe, K.M., Bradner, J.M., Fishman, M.C., and Burdine, R.D. (2009) Mutations in zebrafish leucine-rich repeat-containing six-like affect cilia motility and result in pronephric cysts, but have variable effects on left-right patterning. Development (Cambridge, England). 136(10):1621-1631

Okabe, N., Xu, B., and Burdine, R.D. (2008) Fluid dynamics in zebrafish Kupffer's vesicle. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(12):3602-3612

Baker, K., Holtzman, N.G., and Burdine, R.D. (2008) Direct and indirect roles for Nodal signaling in two axis conversions during asymmetric morphogenesis of the zebrafish heart. Proceedings of the National Academy of Sciences of the United States of America. 105(37):13924-13929

Weber, S., Taylor, J.C., Winyard, P., Baker, K.F., Sullivan-Brown, J., Schild, R., Knüppel, T., Zurowska, A.M., Caldas-Alfonso, A., Litwin, M., Emre, S., Ghiggeri, G.M., Bakkaloglu, A., Mehls, O., Antignac, C., Schaefer, F., and Burdine, R.D. (2008) SIX2 and BMP4 Mutations Associate With Anomalous Kidney Development. Journal of the American Society of Nephrology : JASN. 19(5):891-903

Sullivan-Brown, J., Schottenfeld, J., Okabe, N., Hostetter, C.L., Serluca, F.C., Thiberge, S.Y., and Burdine, R.D. (2008) Zebrafish mutations affecting cilia motility share similar cystic phenotypes and suggest a mechanism of cyst formation that differs from pkd2 morphants. Developmental Biology. 314(2):261-275

Schötz, E.M., Burdine, R.D., Jülicher, F., Steinberg, M.S., Heisenberg, C.P., and Foty, R.A. (2008) Quantitative differences in tissue surface tension influence zebrafish germ layer positioning. HFSP Journal. 2(1):42-56

Fan, X., Hagos, E.G., Xu, B., Sias, C., Kawakami, K., Burdine, R.D., and Dougan, S.T. (2007) Nodal signals mediate interactions between the extra-embryonic and embryonic tissues in zebrafish. Developmental Biology. 310(2):363-378

Schottenfeld, J., Sullivan-Brown, J., and Burdine, R.D. (2007) Zebrafish curly up encodes a Pkd2 ortholog that restricts left-side-specific expression of southpaw. Development (Cambridge, England). 134(8):1605-1615

Lin, S.Y., and Burdine, R.D. (2005) Brain asymmetry: switching from left to right. Current biology : CB. 15(9):R343-345

Dutta, S., Dietrich, J.E., Aspock, G., Burdine, R.D., Schier, A., Westerfield, M., and Varga, Z.M. (2005) pitx3 defines an equivalence domain for lens and anterior pituitary placode. Development (Cambridge, England). 132(7):1579-1590

Hostetter, C.L., Sullivan-Brown, J.L., and Burdine, R.D. (2003) Zebrafish pronephros: A model for understanding cystic kidney disease. Developmental Dynamics : an official publication of the American Association of Anatomists. 228(3):514-522

de la Cruz, J.M., Bamford, R.N., Burdine, R.D., Roessler, E., Barkovich, A.J., Donnai, D., Schier, A.F., and Muenke, M. (2002) A loss-of-function mutation in the CFC domain of TDGF1 is associated with human forebrain defects. Human genetics. 110(5):422-428

Bamford, R.N., Roessler, E., Burdine, R.D., Saplakoglu, U., de la Cruz, J., Splitt, M., Towbin, J., Bowers, P., Marino, B., Schier, A.F., Shen, M.M., Muenke, M., and Casey, B. (2000) Loss-of-function mutations in the EGF-CFC gene CFC1 are associated with human left-right laterality defects. Nature Genetics. 26(3):365-369

Concha, M.L., Burdine, R.D., Russell, C., Schier, A.F., and Wilson, S.W. (2000) A nodal signaling pathway regulates the laterality of neuroanatomical asymmetries in the zebrafish forebrain. Neuron. 28(2):399-409

Burdine, R.D. and Schier, A.F. (2000) Conserved and divergent mechanisms in left-right axis formation. Genes & Development. 14(7):763-776

Yan, Y.T., Gritsman, K., Ding, J., Burdine, R.D., Corrales, J.D., Price, S.M., Talbot, W.S., Schier, A.F., and Shen, M.M. (1999) Conserved requirement for EGF-CFC genes in vertebrate left-right axis formation. Genes & Development. 13(19):2527-2537

NON-ZEBRAFISH PUBLICATIONS
Khan N, Cabo R, Burdine RD, Tan W-H, Keary CJ, Ochoa-Lubinoff C, Bird LM; STARS Investigators (2023) Health-related quality of life and medication use among individuals with Angelman syndrome. Qual Life Res 32(7)2059-2067 PMID:37039911

Menon T, and Burdine RD. (2022) A twist in Pitx2 regulation of gut looping. Dev Cell 57(21):2445-2446 PMID:36347237

Cheng KC, Burdine RD, Dickinson ME, Ekker SC, Lin AY, Kent Lloyd KC, Lutz CM, MacRae CA, Morrison JH, O’Connor D, Postlethwait JH, Rogers CD, Sanchez S, Simpson JH, Talbot WS, Wallace DC, Weimer JM, Bellen HJ. (2022) Promoting validation and cross-phylogenetic integration in model organism research. Dis Model Mech 15(9):dmm049600 PMCID:PMC9531892

Bird LM, Ochoa-Lubinoff C, Tan W-H, Heimer G, Melmed RD, Rakhit A, Visootsak J, During MJ, Holcroft C, Burdine RD, Kolevzon A, and Thibert RL. (2021) The STARS Phase 2 Study: A Randomized Controlled Trial of Gaboxadol in Angelman syndrome. Neurology 96(7):e1024-e1035 PMCID:PMC8055330

Willgoss T, Cassater D, Connor S, Krishnan ML, Miller MT, Barbosa CD, Phillips D, McCormack J, Bird LM, Burdine RD, Claridge S, Bichell TJ. (2021) Measuring What Matters to Individuals with Angelman Syndrome and Their Families: Development of a Patient-Centered Disease Concept Model. Child Psychiatry Hum Dev 52(4): 654-668 PMCID: PMC8238699

Gripp KW, Schill L, Schoyer L, Stronach B, Bennett AM, Blaser S, Brown A, Burdine R, Burkitt-Wright E, Castel P, Darilek S, Dias A, Dyer T, Ellis M, Erickson G, Gelb BD, Green T, Gross A, Ho A, Holder J, Inoue S-I, Jelin AC, Kennedy A, Klein R, Kontaridis M, Magoulas P, McConnell D, McCormick F, Neel BG, Prada CE, Rauen KA, Roberts A, Rodriguez-Viciana P, Rosen N, Rumbaugh G, Sablina A, Solman M, Tartaglia M, Thomas A, Timmer WC, Venkatachalam K, Walsh KS, Wolters PL, Yi J-S, Zenker M, and Ratner N. (2020) The Sixth International RASopathies Symposium: Precision Medicine - From Promise to Practice. Am J Med Genet A 182(3):597-606 PMCID:PMC7021559

Grimes DT and Burdine RD. (2017) Left-Right Patterning: Breaking Symmetry to Asymmetric Morphogenesis. Trends Genet 33(9):616-628 PMCID:PMC5764106

Burdine RD and Caspary T. (2013) Left-right asymmetry: lessons from Cancun. Development 140(22):4465-4470 PMCID:PMC3817937

Park CY, Wong AK, Greene CS, Rowland J, Guan Y, Burdine RD, and Troyanskaya O.G. (2013) Functional knowledge transfer for high-accuracy prediction of under-studied biological processes. PLoS Comput Biol 9(3):e1002957 PMCID:PMC3597527

Daily J, Nash K, Jinwal U, Golde T, Rogers J, Peters MM, Burdine RD, Dickey C, Banko J, and Weeber EJ. (2011) Adenovirus-mediated rescue of the cognitive defects in a mouse model for Angelman Syndrome. PLoS One 6(12):e27221 PMCID:PMC3235088

McSheene JC and Burdine RD. (2011) Examining the establishment of cellular axes using intrinsic chirality. Proc Natl Acad Sci USA 108(30):12191-2 PMCID:PMC3145736

Xu B, Feng X and Burdine RD. (2010) Categorical data analysis in experimental biology. Dev Biol 348 (1):3-11 PMCID:PMC3021327

Jaffe KM and Burdine RD. (2010) More than maintenance? A role for IFT genes in planar cell polarity. J Am Soc Nephrol 21(8):1240-1 PMID:20651164

Goodman, S.J., Branda, C.S., Robinson, M.K., Burdine, R.D., and Stern, M.J. (2003) Alternative splicing affecting a novel domain in the C. elegans EGL-15 FGF receptor confers functional specificity. Development, 130: 3757-3766

Burdine, R.D., Branda, C.S., and Stern, M.J. (1998) EGL-17(FGF) expression coordinates the attraction of the migrating sex myoblasts with vulval induction in C. elegans. Development, 125: 1083-1093.

Burdine, R.D., Chen, E.B., Kwok, S.F. and Stern, M.J. (1997) egl-17 encodes an invertebrate fibroblast growth factor family member required specifically for sex myoblast migration in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U.S.A., 94: 2433-2437.