PUBLICATION
Synaptic vesicle release regulates myelin sheath number of individual oligodendrocytes in vivo
- Authors
- Mensch, S., Baraban, M., Almeida, R., Czopka, T., Ausborn, J., El Manira, A., Lyons, D. A.
- ID
- ZDB-PUB-160817-1
- Date
- 2015
- Source
- Nature Neuroscience 18: 628-630 (Journal)
- Registered Authors
- Almeida, Rafael, Baraban, Marion, Czopka, Tim, Lyons, David A.
- Keywords
- Glial development, Myelin biology and repair, Oligodendrocyte
- MeSH Terms
-
- Animals
- Cell Count
- Chimera
- Embryo, Nonmammalian/cytology
- Embryo, Nonmammalian/drug effects
- GABA-A Receptor Antagonists/pharmacology
- Myelin Sheath/drug effects
- Myelin Sheath/physiology*
- Neurons/drug effects
- Neurons/physiology*
- Oligodendroglia/cytology*
- Oligodendroglia/drug effects
- Pentylenetetrazole/pharmacology
- Spinal Cord/cytology
- Spinal Cord/drug effects
- Synaptic Vesicles
- Tetanus Toxin/pharmacology
- Zebrafish/embryology
- PubMed
- 25849985 Full text @ Nat. Neurosci.
Citation
Mensch, S., Baraban, M., Almeida, R., Czopka, T., Ausborn, J., El Manira, A., Lyons, D. A. (2015) Synaptic vesicle release regulates myelin sheath number of individual oligodendrocytes in vivo. Nature Neuroscience. 18:628-630.
Abstract
The myelination of axons by oligodendrocytes markedly affects CNS function, but how this is regulated by neuronal activity in vivo is not known. We found that blocking synaptic vesicle release impaired CNS myelination by reducing the number of myelin sheaths made by individual oligodendrocytes during their short period of formation. We also found that stimulating neuronal activity increased myelin sheath formation by individual oligodendrocytes. These data indicate that neuronal activity regulates the myelinating capacity of single oligodendrocytes.
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