PUBLICATION
Bis-GMA affects craniofacial development in zebrafish embryos (Danio rerio)
- Authors
- Kramer, A.G., Vuthiganon, J., Lassiter, C.S.
- ID
- ZDB-PUB-160320-1
- Date
- 2016
- Source
- Environmental Toxicology and Pharmacology 43: 159-165 (Journal)
- Registered Authors
- Lassiter, Christopher S.
- Keywords
- BPA, Bis-GMA, Cartilage, Craniofacial, Estrogen, Zebrafish
- MeSH Terms
-
- Acrylic Resins/toxicity*
- Animals
- Bisphenol A-Glycidyl Methacrylate/toxicity*
- Composite Resins/toxicity*
- Embryo, Nonmammalian
- Polyurethanes/toxicity*
- Zebrafish/embryology*
- PubMed
- 26994444 Full text @ Environ. Toxicol. Pharmacol.
Citation
Kramer, A.G., Vuthiganon, J., Lassiter, C.S. (2016) Bis-GMA affects craniofacial development in zebrafish embryos (Danio rerio). Environmental Toxicology and Pharmacology. 43:159-165.
Abstract
Estrogen is a steroid hormone that is vital in vertebrate development and plays a role in a variety of developmental processes including cartilage and craniofacial formation. The effects of estrogen can be mimicked by other compounds found in the environment known as xenoestrogens. Bisphenol-A (BPA) is a known xenoestrogen and is combined with glycidyl methacrylate to make Bisphenol A glycidyl methacrylate (Bis-GMA), a major component in dental resin based composites (RBCs). Bis-GMA based RBCs can release their components into the saliva and bloodstream. Exposure to 1μM and 10μM Bis-GMA in Danio rerio embryos results in increased mortality of approximately 30% and 45% respectively. Changes to gross morphology, specifically craniofacial abnormalities, were seen at concentrations as low as 10nM. While the molecular pathways of Bis-GMA effects have not been studied extensively, more is known about one of the components, BPA. Further research of Bis-GMA could lead to a better understanding of xenoestrogenic activity resulting in improved public and environmental health.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping