ZFIN ID: ZDB-PERS-000913-14
Lassiter, Christopher S.
Email: lassiter@roanoke.edu
URL: https://roanoke.digication.com/chrislassiter/home
Affiliation: Lassiter Lab
Address: Department of Biology Roanoke College 221 College Lane Salem, VA 24153 USA
Country: United States
Phone: (540) 375-2460

My research interests lie in the field of developmental biology. The mechanisms by which a single cell can give rise to a complex organism have always amazed me. Cells must differentiate and signal to each other, turning on vast networks of genes while coordinating growth, shape, and function. Much research has been done on small range signaling molecules during development. During my graduate work, I became interested in molecules that signal over longer ranges: hormones.

My work has focused on the estrogen signaling pathway. Estrogen is an important molecule in the developing embryo and in the adult vertebrate. This small molecule signals in many tissues of the body, including reproductive tissues, adipose, brain, bone, and heart. Estrogen signals by binding to estrogen receptors. My work has involved characterizing the estrogen receptors along with aromatase, the gene that codes for estrogen synthesis. The expression pattern of aromatase in the embryonic brain and its control by steroid hormones is well conserved among vertebrates. The pleiotropic effects of estrogen in the developing brain could affect neural architecture resulting in morphological and behavioral effects well into adulthood.

Walker, B.S., Kramer, A.G., Lassiter, C.S. (2018) Atrazine affects craniofacial chondrogenesis and axial skeleton mineralization in zebrafish ( Danio rerio). Toxicology and industrial health. 34(5):329-338
Crowder, C.M., Lassiter, C.S., Gorelick, D.A. (2017) Nuclear androgen receptor regulates testes organization and oocyte maturation in zebrafish. Endocrinology. 159(2):980-993
Kramer, A.G., Vuthiganon, J., Lassiter, C.S. (2016) Bis-GMA affects craniofacial development in zebrafish embryos (Danio rerio). Environmental Toxicology and Pharmacology. 43:159-165
Pashay Ahi, E., Walker, B.S., Lassiter, C.S., Jónsson, Z.O. (2016) Investigation of the effects of estrogen on skeletal gene expression during zebrafish larval head development. PeerJ. 4:e1878
Cohen, S.P., Lachappelle, A.R., Walker, B.S., Lassiter, C.S. (2014) Modulation of estrogen causes disruption of craniofacial chondrogenesis in Danio rerio. Aquatic toxicology (Amsterdam, Netherlands). 152C:113-120
Allgood, O.E., Hamad, A., Fox, J., Defrank, A., Gilley, R., Dawson, F., Sykes, B., Underwood, T.J., Naylor, R.C., Briggs, A.A., Lassiter, C.S., Bell, W.E., and Turner, J.E. (2013) Estrogen prevents cardiac and vascular failure in the 'listless' zebrafish (Danio rerio) developmental model. General and comparative endocrinology. 189C:33-42
Smolinsky, A.N., Doughman, J.M., Kratzke, L.T., and Lassiter, C.S. (2010) Zebrafish (Danio rerio) androgen receptor: Sequence homology and up-regulation by the fungicide vinclozolin. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 151(2):161-166
Lassiter, C.S., and Linney, E. (2007) Embryonic Expression And Steroid Regulation of Brain Aromatase cyp19a1b in Zebrafish (Danio Rerio). Zebrafish. 4(1):49-58
Lassiter, C.S. (2005) Estrogen receptors and aromatase in zebrafish (Danio rerio) development. Ph.D. Thesis. :157p
Lassiter, C.S., Kelley, B., and Linney, E. (2002) Genomic structure and embryonic expression of estrogen receptor beta a (ERbetaa) in zebrafish (Danio rerio). Gene. 299(1-2):141-151

Abidi F, Jacquot S, Lassiter C, Trivier E, Hanauer A, Schwartz C. 1999. Novel Mutations in Rsk-2, the gene for Coffin-Lowry Syndrome (CLS). Eur J Hum Gen 7:20-26.