PUBLICATION
Signaling networks organizing regenerative growth of the zebrafish fin
- Authors
- Wehner, D., Weidinger, G.
- ID
- ZDB-PUB-150502-8
- Date
- 2015
- Source
- Trends in genetics : TIG 31(6): 336-343 (Review)
- Registered Authors
- Wehner, Daniel, Weidinger, Gilbert
- Keywords
- Wnt, fin regeneration, growth, signaling pathways, zebrafish, β-catenin
- MeSH Terms
-
- Amputation, Surgical
- Animal Fins/metabolism*
- Animal Fins/physiology
- Animal Fins/surgery
- Animals
- Gene Expression
- Gene Regulatory Networks*
- Models, Genetic
- Regeneration/genetics*
- Signal Transduction/genetics*
- Zebrafish/genetics*
- Zebrafish/physiology
- Zebrafish Proteins/genetics
- PubMed
- 25929514 Full text @ Trends Genet.
Citation
Wehner, D., Weidinger, G. (2015) Signaling networks organizing regenerative growth of the zebrafish fin. Trends in genetics : TIG. 31(6):336-343.
Abstract
In contrast to mammals, adult salamanders and fish can completely regenerate their appendages after amputation. The cellular and molecular mechanisms underlying this fascinating phenomenon are beginning to emerge, including substantial progress in the identification of signals that control regenerative growth of the zebrafish caudal fin. Despite the fairly simple architecture of the fin, the regulation of its regeneration is complex. Many signals, including fibroblast growth factor (FGF), Wnt, Hedgehog (Hh), retinoic acid (RA), Notch, bone morphogenic protein (BMP), activin, and insulin-like growth factor (IGF), are required for regeneration. Much work needs to be done to dissect tissue-specific functions of these pathways and how they interact, but Wnt/β-catenin signaling is already emerging as a central player. Surprisingly, Wnt/β-catenin signaling appears to largely indirectly control epidermal patterning, progenitor cell proliferation, and osteoblast maturation via regulation of a multitude of secondary signals.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping