ZFIN Person: Wehner, Daniel

ZFIN ID: ZDB-PERS-100120-4

ZFIN ID: ZDB-PERS-100120-4

Wehner, Daniel

Email:	daniel.wehner@mpl.mpg.de
URL:	http://www.researchgate.net/profile/Daniel_Wehner
Affiliation:	Wehner Lab
Address:	Max Planck Institut for the Science of Light & Max-Planck-Zentrum für Physik und Medizin Division Biological Optomechanics Staudtstr. 2 91058 Erlangen Germany
Country:	Germany
Phone:	+4991317133550
Fax:
ORCID ID:	0000-0003-2880-4759

BIOGRAPHY AND RESEARCH INTERESTS

My research interest is to unravel the mechanisms underlying successful organ regeneration in vertebrates. Current research focusses on elucidating the principles that can lead to functional axonal regeneration in a complex vertebrate central nervous system; with emphasis on the microenvironment. My goal is to inform research in non-regenerating systems.

PUBLICATIONS

Kolb, J., Tsata, V., John, N., Kim, K., Möckel, C., Rosso, G., Kurbel, V., Parmar, A., Sharma, G., Karandasheva, K., Abuhattum, S., Lyraki, O., Beck, T., Müller, P., Schlüßler, R., Frischknecht, R., Wehner, A., Krombholz, N., Steigenberger, B., Beis, D., Takeoka, A., Blümcke, I., Möllmert, S., Singh, K., Guck, J., Kobow, K., Wehner, D. (2023) Small leucine-rich proteoglycans inhibit CNS regeneration by modifying the structural and mechanical properties of the lesion environment. Nature communications. 14:68146814

John, N., Kolb, J., Wehner, D. (2022) Mechanical spinal cord transection in larval zebrafish and subsequent whole-mount histological processing. STAR protocols. 3:101093

Tsata, V., Möllmert, S., Schweitzer, C., Kolb, J., Möckel, C., Böhm, B., Rosso, G., Lange, C., Lesche, M., Hammer, J., Kesavan, G., Beis, D., Guck, J., Brand, M., Wehner, D. (2020) A switch in pdgfrb⁺ cell-derived ECM composition prevents inhibitory scarring and promotes axon regeneration in the zebrafish spinal cord. Developmental Cell. 56(4):509-524.e9

Tsata, V., Kroehne, V., Wehner, D., Rost, F., Lange, C., Hoppe, C., Kurth, T., Reinhardt, S., Petzold, A., Dahl, A., Loeffler, M., Reimer, M.M., Brand, M. (2020) Reactive oligodendrocyte progenitor cells (re-)myelinate the regenerating zebrafish spinal cord. Development (Cambridge, England). 147(24):

Oprişoreanu, A.M., Smith, H.L., Arya, S., Webster, R., Zhong, Z., Eaton-Hart, C., Wehner, D., Cardozo, M.J., Becker, T., Talbot, K., Becker, C.G. (2020) Correction: Interaction of Axonal Chondrolectin with Collagen XIXa1 Is Necessary for Precise Neuromuscular Junction Formation. Cell Reports. 32:108113

Oprişoreanu, A.M., Smith, H.L., Arya, S., Webster, R., Zhong, Z., Wehner, D., Cardozo, M.J., Becker, T., Talbot, K., Becker, C.G. (2019) Interaction of Axonal Chondrolectin with Collagen XIXa1 Is Necessary for Precise Neuromuscular Junction Formation. Cell Reports. 29:1082-1098.e10

Tsarouchas, T.M., Wehner, D., Cavone, L., Munir, T., Keatinge, M., Lambertus, M., Underhill, A., Barrett, T., Kassapis, E., Ogryzko, N., Feng, Y., van Ham, T.J., Becker, T., Becker, C.G. (2018) Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration. Nature communications. 9:4670

Wehner, D., Becker, T., Becker, C.G. (2017) Restoration of anatomical continuity after spinal cord transection depends on Wnt/β-catenin signaling in larval zebrafish. Data in brief. 16:65-70

Wehner, D., Tsarouchas, T.M., Michael, A., Haase, C., Weidinger, G., Reimer, M.M., Becker, T., Becker, C.G. (2017) Wnt signaling controls pro-regenerative Collagen XII in functional spinal cord regeneration in zebrafish. Nature communications. 8:126

Ohnmacht, J., Yang, Y.J., Maurer, G.W., Barreiro-Iglesias, A., Tsarouchas, T.M., Wehner, D., Sieger, D., Becker, C.G., Becker, T. (2016) Spinal motor neurons are regenerated after mechanical lesion and genetic ablation in larval zebrafish. Development (Cambridge, England). 143(9):1464-74

Wehner, D., Jahn, C., Weidinger, G. (2015) Use of the TetON System to Study Molecular Mechanisms of Zebrafish Regeneration. Journal of visualized experiments : JoVE. (100):e52756

Wehner, D., Weidinger, G. (2015) Signaling networks organizing regenerative growth of the zebrafish fin. Trends in genetics : TIG. 31(6):336-343

Stangenberg, R., Wu, Y., Hedrich, J., Kurzbach, D., Wehner, D., Weidinger, G., Kuan, S.L., Jansen, M.I., Jelezko, F., Luhmann, H.J., Hinderberger, D., Weil, T., Müllen, K. (2015) A Polyphenylene Dendrimer Drug Transporter with Precisely Positioned Amphiphilic Surface Patches. Advanced Healthcare Materials. 4(3):377-84

Reuter, H., März, M., Vogg, M.C., Eccles, D., Grífol-Boldú, L., Wehner, D., Owlarn, S., Adell, T., Weidinger, G., Bartscherer, K. (2015) β-Catenin-Dependent Control of Positional Information along the AP Body Axis in Planarians Involves a Teashirt Family Member. Cell Reports. 10(2):253-65

Geurtzen, K., Knopf, F., Wehner, D., Huitema, L.F., Schulte-Merker, S., Weidinger, G. (2014) Mature osteoblasts dedifferentiate in response to traumatic bone injury in the zebrafish fin and skull. Development (Cambridge, England). 141(11):2225-34

Wehner, D., Cizelsky, W., Vasudevaro, M.D., Özhan, G., Haase, C., Kagermeier-Schenk, B., Röder, A., Dorsky, R.I., Moro, E., Argenton, F., Kühl, M., and Weidinger, G. (2014) Wnt/β-Catenin Signaling Defines Organizing Centers that Orchestrate Growth and Differentiation of the Regenerating Zebrafish Caudal Fin. Cell Reports. 6(3):467-481

Özhan, G., Sezgin, E., Wehner, D., Pfister, A.S., Kühl, S.J., Kagermeier-Schenk, B., Kühl, M., Schwille, P., and Weidinger, G. (2013) Lypd6 Enhances Wnt/beta-Catenin Signaling by Promoting Lrp6 Phosphorylation in Raft Plasma Membrane Domains. Developmental Cell. 26(4):331-345

Grotek, B., Wehner, D., and Weidinger, G. (2013) Notch signaling coordinates cellular proliferation with differentiation during zebrafish fin regeneration. Development (Cambridge, England). 140(7):1412-1423

Kagermeier-Schenk, B., Wehner, D., Ozhan-Kizil, G., Yamamoto, H., Li, J., Kirchner, K., Hoffmann, C., Stern, P., Kikuchi, A., Schambony, A., and Weidinger, G. (2011) Waif1/5T4 Inhibits Wnt/β-Catenin Signaling and Activates Noncanonical Wnt Pathways by Modifying LRP6 Subcellular Localization. Developmental Cell. 21(6):1129-43

NON-ZEBRAFISH PUBLICATIONS
Aldine R. Amiel, Stephanie L. Tsai and Daniel Wehner. (2023). “Embracing the diversity of model systems to deconstruct the basis of regeneration and repair”. Development 150(3): dev201579.

Daniel Wehner and Catherina G Becker. (2022). "An exception to the rule? Regeneration of the injured spinal cord in the spiny mouse". Developmental Cell 57(4): 415-416.

Leonardo Cavone, Tess McCann, Louisa K Drake, Erika A Aguzzi, Ana-Maria Oprişoreanu, Elisa Pedersen, Soe Sandi, Jathurshan Selvarajah, Themistoklis M Tsarouchas, Daniel Wehner, Marcus Keatinge, Karolina S Mysiak, Beth E P Henderson, Ross Dobie, Neil C Henderson, Thomas Becker, Catherina G Becker. (2021). “A unique macrophage subpopulation signals directly to spinal progenitor cells to promote regenerative neurogenesis in the zebrafish spinal cord”. Developmental Cell 56(11): 1617-1630.e6.

Gonzalo Rosso, Daniel Wehner, Christine Schweitzer, Stephanie Möllmert, Elisabeth Sock, Jochen Guck and Victor Sahin. (2021). ”Matrix Stiffness mechanosensing modulates the expression and distribution of transcription factors in Schwann cells”. Bioengineering & Translational Medicine: e10257. doi:10.1002/btm2.10257

Hemanth Tummala, Stewart Fleming, Paul M. Hocking, Daniel Wehner, Zahid Naseem, Manir Ali, Christopher F Inglehearn, Nikolai Zhelev and Douglas H. Lester (2011). "The D153del mutation in GNB3 gene causes tissue specific signalling patterns and an abnormal renal morphology in Rge chickens." PLoS One 6(8): e21156