PUBLICATION

Melatonin Is Required for the Circadian Regulation of Sleep

Authors
Gandhi, A.V., Mosser, E.A., Oikonomou, G., Prober, D.A.
ID
ZDB-PUB-150311-4
Date
2015
Source
Neuron   85(6): 1193-9 (Journal)
Registered Authors
Prober, David
Keywords
none
MeSH Terms
  • Animals
  • Animals, Genetically Modified/genetics
  • Arylalkylamine N-Acetyltransferase/genetics
  • Circadian Clocks/genetics
  • Circadian Rhythm/genetics
  • Circadian Rhythm/physiology*
  • Genotype
  • Light
  • Melatonin/metabolism*
  • Sleep/physiology*
  • Zebrafish/physiology*
PubMed
25754820 Full text @ Neuron
Abstract
Sleep is an evolutionarily conserved behavioral state whose regulation is poorly understood. A classical model posits that sleep is regulated by homeostatic and circadian mechanisms. Several factors have been implicated in mediating the homeostatic regulation of sleep, but molecules underlying the circadian mechanism are unknown. Here we use animals lacking melatonin due to mutation of arylalkylamine N-acetyltransferase 2 (aanat2) to show that melatonin is required for circadian regulation of sleep in zebrafish. Sleep is dramatically reduced at night in aanat2 mutants maintained in light/dark conditions, and the circadian regulation of sleep is abolished in free-running conditions. We find that melatonin promotes sleep downstream of the circadian clock as it is not required to initiate or maintain circadian rhythms. Additionally, we provide evidence that melatonin may induce sleep in part by promoting adenosine signaling, thus potentially linking circadian and homeostatic control of sleep.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes