PUBLICATION
Pigment patterns in adult fish result from superimposition of two largely independent pigmentation mechanisms
- Authors
- Ceinos, R.M., Guillot, R., Kelsh, R.N., Cerdá-Reverter, J.M., Rotllant, J.
- ID
- ZDB-PUB-141204-5
- Date
- 2015
- Source
- Pigment cell & melanoma research 28(2): 196-209 (Journal)
- Registered Authors
- Cerdá-Reverter, José Miguel, Kelsh, Robert, Rotllant, Josep
- Keywords
- asip1, dct, ltk, mitfa, tyrp1b, xdh, Agouti, chromatophore, iridophore, melanocyte, melanophore, pigment pattern formation, transgenic, zebrafish
- MeSH Terms
-
- Animals
- Cell Count
- Gene Expression Regulation, Developmental
- Larva/genetics
- Melanophores/metabolism
- Pigmentation*/genetics
- RNA, Messenger/genetics
- RNA, Messenger/metabolism
- Time Factors
- Zebrafish/genetics
- Zebrafish/growth & development
- Zebrafish/physiology*
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- PubMed
- 25469713 Full text @ Pigment Cell Melanoma Res.
Citation
Ceinos, R.M., Guillot, R., Kelsh, R.N., Cerdá-Reverter, J.M., Rotllant, J. (2015) Pigment patterns in adult fish result from superimposition of two largely independent pigmentation mechanisms. Pigment cell & melanoma research. 28(2):196-209.
Abstract
Dorso-ventral pigment pattern differences are the most widespread pigmentary adaptations in vertebrates. In mammals, this pattern is controlled by regulating melanin chemistry in melanocytes using a protein, ASIP. In fish, studies of pigment patterning have focused on stripe formation, identifying a core striping mechanism dependent upon interactions between different pigment cell types. In contrast, mechanisms driving the dorso-ventral countershading pattern have been overlooked. Here, we demonstrate that, in fact, zebrafish utilize two distinct adult pigment patterning mechanisms - an ancient dorso-ventral patterning mechanism, and a more recent striping mechanism based on cell-cell interactions; remarkably, the dorso-ventral patterning mechanism also utilizes ASIP. These two mechanisms function largely independently, with resultant patterns superimposed to give the full pattern. This article is protected by copyright. All rights reserved.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping