ZFIN Person: Rotllant, Josep

ZFIN ID: ZDB-PERS-060727-6

ZFIN ID: ZDB-PERS-060727-6

Rotllant, Josep

Email:	rotllant@iim.csic.es
URL:	http://www.iim.csic.es
Affiliation:	Rotllant Lab
Address:	Instituto de Investigaciones Marinas (IIM) Consejo Superior de Investigaciones Cientificas (CSIC) Eduardo Cabello 6 Vigo. Pontevedra, E-36208 Spain including Canary Islands, Ceuta and Melilla
Country:	Spain
Phone:	+34 986 231 930 Ext. 288
Fax:	+34 986 292 762
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

Musculo-skeletal and integumentary system development.

PUBLICATIONS

Godino-Gimeno, A., Leal, E., Chivite, M., Tormos, E., Rotllant, J., Vallone, D., Foulkes, N.S., Míguez, J.M., Cerdá-Reverter, J.M. (2024) Role of melanocortin system in the locomotor activity rhythms and melatonin secretion as revealed by agouti-signalling protein (asip1) overexpression in zebrafish. Journal of pineal research. 76:e12939e12939

Rocha, A., Godino-Gimeno, A., Rotllant, J., Cerdá-Reverter, J.M. (2023) Agouti-Signalling Protein Overexpression Reduces Aggressiveness in Zebrafish. Biology. 12(5):

Fierro-Castro, C., Rotllant, J., Cerdá-Reverter, J.M., Tort, L. (2022) Loss-of-function mutations in melanocortin-1 receptor modulate immune response in teleost fishes. Fish & shellfish immunology. 131:838-846

Navarro, S., Crespo, D., Schulz, R.W., Ge, W., Rotllant, J., Cerdá-Reverter, J.M., Rocha, A. (2022) Role of the Melanocortin System in Gonadal Steroidogenesis of Zebrafish. Animals : an open access journal from MDPI. 12(20):

Leal, E., Angotzi, A.R., Gregório, S.F., Ortiz-Delgado, J.B., Rotllant, J., Fuentes, J., Tafalla, C., Cerdá-Reverter, J.M. (2022) Role of the melanocortin system in zebrafish skin physiology. Fish & shellfish immunology. 130:591-601

Godino-Gimeno, A., Sánchez, E., Guillot, R., Rocha, A., Angotzi, A.R., Leal, E., Rotllant, J., Cerdá-Reverter, J.M. (2020) Growth Performance After Agouti-Signaling Protein 1 (Asip1) Overexpression in Transgenic Zebrafish. Zebrafish. 17(6):373-381

Castro-Sánchez, S., Suarez-Bregua, P., Novas, R., Álvarez-Satta, M., Badano, J.L., Rotllant, J., Valverde, D. (2020) Author Correction: Functional analysis of new human Bardet-Biedl syndrome loci specific variants in the zebrafish model. Scientific Reports. 10:2876

Castro-Sánchez, S., Suarez-Bregua, P., Novas, R., Álvarez-Satta, M., Badano, J.L., Rotllant, J., Valverde, D. (2019) Functional analysis of new human Bardet-Biedl syndrome loci specific variants in the zebrafish model. Scientific Reports. 9:12936

Cal, L., Suarez-Bregua, P., Braasch, I., Irion, U., Kelsh, R., Cerdá-Reverter, J.M., Rotllant, J. (2019) Loss-of-function mutations in the melanocortin-1-receptor (Mc1r) cause disruption of dorso-ventral countershading in teleost fish. Pigment cell & melanoma research. 32(6):817-828

Cal, L., Suarez-Bregua, P., Comesaña, P., Owen, J., Braasch, I., Kelsh, R., Cerdá-Reverter, J.M., Rotllant, J. (2019) Countershading in zebrafish results from an Asip1 controlled dorsoventral gradient of pigment cell differentiation. Scientific Reports. 9:3449

Cal, L., MegÍas, M., Cerdá-Reverter, J.M., Postlethwait, J.H., Braasch, I., Rotllant, J. (2017) BAC Recombineering of the Agouti Loci from Spotted Gar and Zebrafish Reveals the Evolutionary Ancestry of Dorsal-Ventral Pigment Asymmetry in Fish. Journal of experimental zoology. Part B, Molecular and developmental evolution. 328(7):697-708

Suarez-Bregua, P., Saxena, A., Bronner, M.E., Rotllant, J. (2017) Targeted Pth4-expressing cell ablation impairs skeletal mineralization in zebrafish. PLoS One. 12:e0186444

Suarez-Bregua, P., Cal, L., Cañestro, C., Rotllant, J. (2017) PTH Reloaded: A New Evolutionary Perspective. Frontiers in Physiology. 8:776

Suarez-Bregua, P., Chien, C.J., Megias, M., Du, S.D., Rotllant, J. (2017) Promoter architecture and transcriptional regulation of musculoskeletal embryonic nuclear protein 1b (mustn1b) gene in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 246(12):992-1000

Suarez-Bregua, P., Torres-Nuñez, E., Saxena, A., Guerreiro, P., Braasch, I., Prober, D.A., Moran, P., Cerda-Reverter, J.M., Du, S.J., Adrio, F., Power, D.M., Canario, A.V., Postlethwait, J.H., Bronner, M.E., Cañestro, C., Rotllant, J. (2017) Pth4, an ancient parathyroid hormone lost in eutherian mammals, reveals a new brain-to-bone signaling pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 31:569-583

Guillot, R., Muriach, B., Rocha, A., Rotllant, J., Kelsh, R.N., Cerdá-Reverter, J.M. (2016) Thyroid Hormones Regulate Zebrafish Melanogenesis in a Gender-Specific Manner. PLoS One. 11:e0166152

Guillot, R., Cortés, R., Navarro, S., Mischitelli, M., García-Herranz, V., Sánchez, E., Cal, L., Navarro, J.C., Míguez, J., Afanasyev, S., Krasnov, A., Cone, R.D., Rotllant, J., Cerdá-Reverter, J.M. (2016) Behind melanocortin antagonist overexpression in the zebrafish brain: A behavioral and transcriptomic approach. Hormones and behavior. 82:87-100

Cerdá-Reverter, J.M., Rotllant, J., Kelsh, R.N. (2015) Spots, not stripes, from just holding on. Pigment cell & melanoma research. 28(6):644-6

Torres-Núñez, E., Suarez-Bregua, P., Cal, L., Cal, R., Cerdá-Reverter, J.M., Rotllant, J. (2015) Molecular cloning and characterization of the matricellular protein Sparc/Osteonectin in flatfish, Scophthalmus maximus, and its developmental stage-dependent transcriptional regulation during metamorphosis. Gene. 568(2):129-39

Torres-Núñez, E., Cal, L., Suarez-Bregua, P., Gomez-Marin, C., Moran, P., Gomez-Skarmeta, J., Rotllant, J. (2015) Matricellular protein SPARC/Osteonectin expression is regulated by DNA methylation in its core promoter region. Developmental Dynamics : an official publication of the American Association of Anatomists. 244(5):693-702

Ceinos, R.M., Guillot, R., Kelsh, R.N., Cerdá-Reverter, J.M., Rotllant, J. (2015) Pigment patterns in adult fish result from superimposition of two largely independent pigmentation mechanisms. Pigment cell & melanoma research. 28(2):196-209

Ceinos, R.M., Torres-Nuñez, E., Chamorro, R., Novoa, B., Figueras, A., Ruane, N.M., and Rotllant, J. (2013) Critical Role of the Matricellular Protein SPARC in Mediating Erythroid Progenitor Cell Development in Zebrafish. Cells, tissues, organs. 197(3):196-208

Torres-Nuñez, E., Sobrino, C., Neale, P.J., Ceinos, R.M., Du, S.J., and Rotllant, J. (2012) Molecular Response to Ultraviolet Radiation Exposure in Fish Embryos: Implications for Survival and Morphological Development. Photochemistry and photobiology. 88(3):701-707

Cerdá-Reverter, J.M., Agulleiro, M.J., R, R.G., Sánchez, E., Ceinos, R., and Rotllant, J. (2011) Fish melanocortin system. European Journal of Pharmacology. 660(1):53-60

Monroig, O., Rotllant, J., Cerda-Reverter, J.M., Dick, J.R., Figueras, A., and Tocher, D.R. (2010) Expression and role of Elovl4 elongases in biosynthesis of very long-chain fatty acids during zebrafish Danio rerio early embryonic development. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1801(10):1145-1154

Monroig, O., Rotllant, J., Sánchez, E., Cerdá-Reverter, J.M., and Tocher, D.R. (2009) Expression of long-chain polyunsaturated fatty acid (LC-PUFA) biosynthesis genes during zebrafish Danio rerio early embryogenesis. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1791(11):1093-1101

Rotllant, J., Liu, D., Yan, Y.L., Postlethwait, J.H., Westerfield, M., and Du, S.J. (2008) Sparc (Osteonectin) functions in morphogenesis of the pharyngeal skeleton and inner ear. Matrix biology : journal of the International Society for Matrix Biology. 27(6):561-572

Du, S.J., Rotllant, J., and Tan, X. (2006) Muscle-specific expression of the smyd1 gene is controlled by its 5.3-kb promoter and 5'-flanking sequence in zebrafish embryos. Developmental Dynamics : an official publication of the American Association of Anatomists. 235(12):3306-3315

Tan, X., Rotllant, J., Li, H., Dedeyne, P., and Du, S.J. (2006) SmyD1, a histone methyltransferase, is required for myofibril organization and muscle contraction in zebrafish embryos. Proceedings of the National Academy of Sciences of the United States of America. 103(8):2713-2718

NON-ZEBRAFISH PUBLICATIONS
Prado-Alvarez M, Rotllant J, Gestal C, Novoa B, Figueras A. (2009). Characterization of a C3 and a factor B-like in the carpet-shell clam, Ruditapes decussatus. Fish Shellfish Immunol. 2009 Feb;26(2):305-15.

Fuentes,J., Guerreiro,P.M., Modesto, T., Rotllant,J., Canario, A.V.M. and Power, D.M. (2007). A PTH/PTHrP receptor antagonist blocks the hypercalcemic and hyperphosphatemic response to estradiol-17². AJP: Regulatory, Integrative and Comparative Physiology. 293(2):956-60.

Guerreiro, P.M., Rotllant, J., Fuentes, J., Power, D.M. and Canario, A.V.M. (2006). Cortisol and parathyroid hormone-related peptide are reciprocally modulated by negative feedback. Gen. Comp. Endocrinol 148(2):227-35.

Rotllant, J., Ruane, N.M., Dinis, M.T., Canario, A.V.M. & Power, D.M. (2006). Catecholamine stimulation of cortisol secretion from sea bass (Dicentrarchus labrax L.) head-kidney cells via a b-adrenergic receptor-cAMP signalling pathway. Comparative Biochemistry and Physiology, Part A. 143(3):375-81.

Canario A.V.M., Rotllant, J., Fuentes, J., Guerreiro, P.M., Power, D.M. and Clark, M.S. (2006). Novel bioactive parathyroid hormone and related peptides in teleost fish. FEBS Letters 580(1):291-9.

Rotllant, J., Fernandes, H., Redruello, B., Guerreiro, P.M., Apolónia, L., Anjos, L., Canario, A.V.M. and Power. (2005). Ligand binding and signalling pathways of PTH receptors in sea bream (Sparus auratus) enterocytes. Cell and Tissue Research 28:1-9.

Rotllant, J., Redruello, B., Guerreiro, P.M., Fernandes, H., Canario, AVM. and Power D.M. (2005). Calcium mobilization from fish scales is mediated by PTHrP via the PTH-1-Receptor. Regulatory peptides 132:33-40.

Anjos, L., Rotllant, J., Guerreiro, P.M., Canario, A.V.M., Power, D.M. (2005). Production and characterization gilthead sea bream (Sparus auratus) recombinant Parathyroid Hormone-related Protein. Gen .Comp. Endocrinol. 143(1):57-65.

Redruello, B., Estevao, M.D., Rotllant, J., Guerreiro, J.M., Anjos, L., Canario, A.V.M., Power, D.M. (2005). Isolation and Characterization of Sea bream Osteonectin in Calcifying Tissue and its Downregulation by Piscine Parathyroid Hormone-Related Protein. J. Bone Miner. Res. 20(4):682-92.

Rotllant, J., Guerreiro, P.M., Anjos, L., Redruello, B., Canario, A.V.M., and Power, D.M. (2005). Stimulation of cortisol release by the N-terminus of teleost Parathyroid Hormone-Related Protein in interrenal cells in vitro. Endocrinology. 146(1):71-76.

Abbink, W., Bevelander, G.S., Rotllant, J., Canario, A.V., Flik, G. (2004). Calcium handling in Sparus auratus: effects of water and dietary calcium levels on mineral composition, cortisol and PTHrP levels. J. Exp. Biol. 1;207:4077-84.

Rotllant, J., Parra, D., Peters, R., Boshra, H and J. O. Sunyer. (2004). Generation, purification and functional characterization of three C3a anaphylatoxins in rainbow trout: Role in leukocyte chemotaxis and respiratory burst. Dev. Comp. Immunol. 28:815-828.

Guerreiro, P.M., Fuentes, J., Flik, G., Rotllant, J., Power, D.M., and Canario, A.V.M. (2004). Water calcium concentration modifies whole-body calcium uptake in sea bream larvae during short-term adaptation to altered salinities. J. Exp. Biol. 207: 645-653.

Tort, L., Rotllant, J., Liarte, C., Acerete, L., Hernandez, A., Ceulemans, S, Coutteau, P., Padros, F. (2004). Effects of temperature decrease on feeding rates, immune indicators and histopathological changes of gilthead seabream Sparus aurata fed with an experimental diet. Aquaculture. 229:55-65.

Rotllant, J., Ruane, N.M., Cavallero, M.J., Montero, D. and Tort, L. (2003). Response to confinement in sea bass (Dicentrarchus labrax) is characterised by an increased biosynthetic capacity of interrenal tissue with no effect on ACTH sensitivity. Comparative Biochemistry and Physiology, Part A. 136(3): 613-620.

Rotllant, J., G.P. Worthington, J. Fuentes, P.M. Guerreiro, C.A. Teitsma, P.M. Ingleton, R.J. Balment, A.V.M. Canario and D.M. Power. (2003). Determination of tissue and plasma concentrations of PTHrP in fish: Development and validation of a radioimmunoassay using a teleost 1-34 N-terminal peptide. Gen. Comp. Endocrinol. 133(1): 146-153.

Rotllant, J., Montero, D., Caballero, M.J., Robaina,L., Izquierdo, M.S. and Tort, L. (2003). Differences in interrenal tissue, biosynthetic capacity and ACTH sensitivity in progeny of sea bream from parents selected for high or low cortisol response. J. Fish. Biol. 62, 744-748.

Rotllant, J., Balm, P.H.M., Pavlidis, M., Divanach, P., Weendelar Bonga, S.E., Tort, L. (2003). Background colour influence on the stress response in the red porgy Pagrus pagrus. Aquaculture. 223:129-139.

Haond, C., Nolan D.T., Ruane, N.M., Rotllant, J., and Wendelaar-Bonga, S.E. (2003). Cortisol influences the host-parasite interaction between the rainbow trout (Oncorhynchus mykiis) and the crustacean ectoparasite Argulus japonicus. Parasitology. 127(Pt 6):551-60.

Rotllant, J., Fuentes, J., Guerreiro, P.M., Canario, A.V.M., Power, D.M. (2002). Possible relationship between corticosteroids and PTHrP in teleost fish: in-vitro and in-vivo physiology. Comp. Biochem. Physiol Part A. 132 S41-S49.

Rotllant, J., Balm, P.H.M., Pérez-Sánchez, J., Weendelar-Bonga, S.E., Tort, L. (2001). Pituitary and interrenal function in gilthead sea bream (Sparus aurata, L.) after handling and confinement stress. Gen. Comp. Endocrinol. 121(3): 333-342.

Rotllant, J., Arends, R.J., Mancera, J.M., Wendelaar Bonga, S.E., Flik, G., Tort, L. (2000). Inhibition of HPI axis response to stress in gilthead sea bream (Sparus aurata) with physiological plasma levels of cortisol. Fish. Physiol. Biochem. 23: 13-22.

Rotllant, J., Balm, P.H.M., Pérez-Sánchez, J., Weendelar-Bonga, S.E., Tort, L. (2000). Pituitary proopiomelanocortin-derived peptides and HPI axis activity in Gilthead sea bream (Sparus aurata) during prolonged crowding stress: differential regulation of ACTH and a-MSH release by CRH and TRH. Gen. Comp. Endocrinol. 119: 152-163.

Rotllant, J., Balm, P.H.M., Pérez-Sánchez, J., Weendelar-Bonga, S.E., Tort, L. (2000). A drop in ambient temperature results in a transient reduction of interrenal ACTH responsiveness in gilthead sea bream (Sparus aurata, L.). Fish. Physiol. Biochem. 23: 265-273.

Ruane, N.M., Nolan, D.T., Rotllant, J., Costelloe, J., Wendelaar Bonga, S.E. (2000). Experimental exposure of rainbow trout to the infective stages of the sea louse influences the physiological response to an acute stressor. Fish and Shellfish Immunology 10, 451-463.

Arends, R.J., Rotllant, J., Mancera, J.M., Wendelaar Bonga, S.E., Flick, G. (2000). a-melanocyte stimulating hormone acetylation in the pituitary gland of the sea bream (Sparus aurata, L.) in response to air exposure, confinement and different backgrounds. J. Endocrinology, 166: 427-435.

Ruane, N.M., Nolan, D.T., Rotllant, J., Balm, P.H.M., Tort, L., Wendelaar Bonga, S.E. (1999). Modulation of the stress response of rainbow trout, Oncorhynchus mykiis Walbaum, to confinement by Argulus foliaceus L. (Crustacea: Branchiura) infestation and cortisol feeding. Fish. Physiol. Biochem. 20:43-51.

Tort, L., Padros, F., Rotllant, J., Crespo, S. (1998). Winter syndrome in gilthead sea bream Sparus aurata. Immunological and histophatological features. Fish and Shellfish immunology, 8: 37-46.

Tort, L., Rotllant, J., Rovira, L. (1998). Immunological suppression in gilthead sea bream Sparus aurata of northwest Mediterranean during low temperature periods. Comparative Biochemistry and Physiology, A120: 175-179.

Tort, L., Rotllant, J. and Rovira, L. (1997). Immunosuppression in sea bream (Sparus aurata) affected by the winter syndrome. Developmental & Comparative Immunology, Volume 21, Issue 2, Page 172.

Rotllant, J. and Tort.L. (1997). Cortisol and glucose responses after acute stress by net handling in the sparid red porgy previously subjected to crowding stress. J. Fish Biology, 51: 21-28.

Rotllant, J., Pavlidis, M., Kentouri, M., Abad, M.E., Tort, L. (1997). Non-specific immune responses in the red porgy Pagrus pagrus after crowding stress. Aquaculture, 156: 279-290.