ZFIN ID: ZDB-PUB-140903-24
The teleost agouti-related protein 2 gene is an ohnolog gone missing from the tetrapod genome
Braasch, I., and Postlethwait, J.H.
Date: 2011
Source: Proceedings of the National Academy of Sciences of the United States of America   108(13): E47-E48 (Journal)
Registered Authors: Braasch, Ingo, Postlethwait, John H.
Keywords: none
MeSH Terms:
  • Agouti-Related Protein/genetics*
  • Animals
  • Biological Evolution
  • Fishes/genetics*
  • Gene Duplication
  • Genome*
  • Protein Isoforms/genetics*
PubMed: 21406593 Full text @ Proc. Natl. Acad. Sci. USA

A central question in evolutionary genomics is how morphological differences between taxa arise from differences in gene repertoire. Answers require rigorous orthology assignments. Recent work (1) illuminated the mechanism of background adaptation in teleost fishes by investigating the function of agouti-related protein 2 (agrp2), a gene so far found only in teleosts.