PUBLICATION
NaSH in the construction of thiophene ring fused with N-heterocycles: A rapid and inexpensive synthesis of novel small molecules as potential inducers of apoptosis
- Authors
- Kolli, S.K., Nakhi, A., Medishetti, R., Yellanki, S., Kulkarni, P., Ramesh Raju, R., Pal, M.
- ID
- ZDB-PUB-140830-8
- Date
- 2014
- Source
- Bioorganic & medicinal chemistry letters 24(18): 4460-5 (Journal)
- Registered Authors
- Kulkarni, Pushkar
- Keywords
- Apoptosis, Pyrazine, Quinoxaline, Thiophene
- MeSH Terms
-
- Animals
- Apoptosis/drug effects*
- Crystallography, X-Ray
- Dose-Response Relationship, Drug
- Heterocyclic Compounds/chemistry*
- Models, Molecular
- Molecular Structure
- Small Molecule Libraries/chemical synthesis
- Small Molecule Libraries/chemistry
- Small Molecule Libraries/pharmacology*
- Structure-Activity Relationship
- Sulfides/chemistry*
- Thiophenes/chemical synthesis
- Thiophenes/chemistry
- Thiophenes/pharmacology*
- Zebrafish/embryology
- PubMed
- 25168747 Full text @ Bioorg. Med. Chem. Lett.
Citation
Kolli, S.K., Nakhi, A., Medishetti, R., Yellanki, S., Kulkarni, P., Ramesh Raju, R., Pal, M. (2014) NaSH in the construction of thiophene ring fused with N-heterocycles: A rapid and inexpensive synthesis of novel small molecules as potential inducers of apoptosis. Bioorganic & medicinal chemistry letters. 24(18):4460-5.
Abstract
A facile construction of a thiophene ring fused with N-heterocycles has been achieved via the reaction of NaSH with 2-chloro-3-alkynyl quinoxalines/pyrazines leading to novel 2-substituted thieno[2,3-b]pyrazine/quinoxaline derivatives as potential inducers of apoptosis. Some of them showed encouraging pharmacological properties when tested in zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping