ZFIN ID: ZDB-PERS-171101-1
Kulkarni, Pushkar
Email: pushkark@drils.org
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Affiliation:
Address: Dr. Reddy's Institute of Life Sciences, University of Hyderabad
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BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Medishetti, R., Rani, R., Kavati, S., Mahilkar, A., Akella, V., Saxena, U., Kulkarni, P., Sevilimedu, A. (2020) A DNAzyme based knockdown model for Fragile-X syndrome in zebrafish reveals a critical window for therapeutic intervention. Journal of Pharmacological and Toxicological Methods. 101:106656
Sunke, R., Bankala, R., Thirupataiah, B., Ramarao, E.V.V.S., Kumar, J.S., Doss, H.M., Medishetti, R., Kulkarni, P., Kapavarapu, R.K., Rasool, M., Mudgal, J., Mathew, J.E., Shenoy, G.G., Parsa, K.V.L., Pal, M. (2019) InCl3 mediated heteroarylation of indoles and their derivatization via CH activation strategy: Discovery of 2-(1H-indol-3-yl)-quinoxaline derivatives as a new class of PDE4B selective inhibitors for arthritis and/or multiple sclerosis. European Journal of Medicinal Chemistry. 174:198-215
Dwivedi, S., Medishetti, R., Rani, R., Sevilimedu, A., Kulkarni, P., Yogeeswari, P. (2019) Larval zebrafish model for studying the effects of valproic acid on neurodevelopment: An approach towards modeling autism. Journal of Pharmacological and Toxicological Methods. 95:56-65
Kulkarni, P., Medishetti, R., Nune, N., Yellanki, S., Sripuram, V., Rao, P., Sriram, D., Saxena, U., Oruganti, S., Yogeeswari, P. (2017) Correlation of pharmacokinetics and brain penetration data of adult zebrafish with higher mammals including humans. Journal of Pharmacological and Toxicological Methods. 88(Pt 2):147-152
Kulkarni, P., Yellanki, S., Medishetti, R., Sriram, D., Saxena, U., Yogeeswari, P. (2017) Novel Zebrafish EAE model: A quick in vivo screen for multiple sclerosis. Multiple sclerosis and related disorders. 11:32-39
Bhanushali, U., Kalekar-Joshi, S., Kulkarni-Munshi, R., Yellanki, S., Medishetty, R., Kulkarni, P., Ramaa, C.S. (2017) Design, synthesis and evaluation of 5-pyridin-4-yl-2-thioxo-[1,3,4]oxadiazol-3-yl derivatives as anti-angiogenic agents Targeting VEGFR-2. Anti-cancer agents in medicinal chemistry. 17(1):67-74
Jeankumar, V.U., Saxena, S., Vats, R., Reshma, R.S., Janupally, R., Kulkarni, P., Yogeeswari, P., Sriram, D. (2016) Structure-Guided Discovery of Antitubercular Agents That Target the Gyrase ATPase Domain. ChemMedChem. 11:539-48
Medapi, B., Meda, N., Kulkarni, P., Yogeeswari, P., Sriram, D. (2016) Development of acridine derivatives as selective Mycobacterium tuberculosis DNA gyrase inhibitors. Bioorganic & Medicinal Chemistry. 24:877-85
Bobesh, K.A., Renuka, J., Srilakshmi, R.R., Yellanki, S., Kulkarni, P., Yogeeswari, P., Sriram, D. (2016) Replacement of cardiotoxic aminopiperidine linker with piperazine moiety reduces cardiotoxicity? Mycobacterium tuberculosis novel bacterial topoisomerase inhibitors. Bioorganic & Medicinal Chemistry. 24:42-52
Janupally, R., Medepi, B., Brindha Devi, P., Suryadevara, P., Jeankumar, V.U., Kulkarni, P., Yogeeswari, P., Sriram, D. (2015) Design and Biological Evaluation of Furan/Pyrrole/Thiophene-2-carboxamide Derivatives as Efficient DNA GyraseB Inhibitors of Staphylococcus aureus. Chemical Biology & Drug Design. 86:918-25
Jeankumar, V.U., Reshma, R.S., Janupally, R., Saxena, S., Sridevi, J.P., Medapi, B., Kulkarni, P., Yogeeswari, P., Sriram, D. (2015) Enabling the (3 + 2) cycloaddition reaction in assembling newer anti-tubercular lead acting through the inhibition of the gyrase ATPase domain: lead optimization and structure activity profiling. Organic & biomolecular chemistry. 13:2423-31
Jeankumar, V.U., Kotagiri, S., Janupally, R., Suryadevara, P., Sridevi, J.P., Medishetti, R., Kulkarni, P., Yogeeswari, P., Sriram, D. (2015) Exploring the gyrase ATPase domain for tailoring newer anti-tubercular drugs: hit to lead optimization of a novel class of thiazole inhibitors. Bioorganic & Medicinal Chemistry. 23:588-601
Sridevi, J.P., Anantaraju, H.S., Kulkarni, P., Yogeeswari, P., Sriram, D. (2014) Optimization and validation of Mycobacterium marinum-induced adult zebrafish model for evaluation of oral anti-tuberculosis drugs. International journal of mycobacteriology. 3:259-67
Janupally, R., Jeankumar, V.U., Bobesh, K.A., Soni, V., Devi, P.B., Pulla, V.K., Suryadevara, P., Chennubhotla, K.S., Kulkarni, P., Yogeeswari, P., Sriram, D. (2014) Structure-guided design and development of novel benzimidazole class of compounds targeting DNA gyraseB enzyme of Staphylococcus aureus. Bioorganic & Medicinal Chemistry. 22:5970-87
Sunke, R., Babu, P.V., Yellanki, S., Medishetti, R., Kulkarni, P., Pal, M. (2014) Ligand-free MCR for linking quinoxaline framework with a benzimidazole nucleus: a new strategy for the identification of novel hybrid molecules as potential inducers of apoptosis. Organic & biomolecular chemistry. 12(35):6800-5
Kolli, S.K., Nakhi, A., Medishetti, R., Yellanki, S., Kulkarni, P., Ramesh Raju, R., Pal, M. (2014) NaSH in the construction of thiophene ring fused with N-heterocycles: A rapid and inexpensive synthesis of novel small molecules as potential inducers of apoptosis. Bioorganic & medicinal chemistry letters. 24(18):4460-5
Jeankumar, V.U., Renuka, J., Kotagiri, S., Saxena, S., Kakan, S.S., Sridevi, J.P., Yellanki, S., Kulkarni, P., Yogeeswari, P., Sriram, D. (2014) Gyrase ATPase domain as an antitubercular drug discovery platform: structure-based design and lead optimization of nitrothiazolyl carboxamide analogues. ChemMedChem. 9:1850-9
Prasad, B., Sreenivas, B.Y., Sushma, A., Yellanki, S., Medisetti, R., Kulkarni, P., Pal, M. (2014) A Pd-based regioselective strategy to indole-1,2-fused 8- and 9-membered rings: their evaluation as potential scaffolds for apoptosis in zebrafish. Organic & biomolecular chemistry. 12:2864-8
Jeankumar, V.U., Renuka, J., Pulla, V.K., Soni, V., Sridevi, J.P., Suryadevara, P., Shravan, M., Medishetti, R., Kulkarni, P., Yogeeswari, P., and Sriram, D. (2014) Development of novel N-linked aminopiperidine-based mycobacterial DNA gyrase B inhibitors: Scaffold hopping from known antibacterial leads. International Journal of Antimicrobial Agents. 43(3):269-78
Kulkarni, P., Chaudhari, G.H., Sripuram, V., Banote, R.K., Kirla, K.T., Sultana, R., Rao, P., Oruganti, S., Chatti, K. (2014) Oral dosing in adult zebrafish: Proof-of-concept using pharmacokinetics and pharmacological evaluation of carbamazepine. Pharmacological reports : PR. 66:179-183
Babu, P.V., Mukherjee, S., Deora, G.S., Chennubhotla, K.S., Medisetti, R., Yellanki, S., Kulkarni, P., Sripelly, S., Parsa, K.V., Chatti, K., Mukkanti, K., and Pal, M. (2013) Ligand/PTC-free intramolecular Heck reaction: synthesis of pyrroloquinoxalines and their evaluation against PDE4/luciferase/oral cancer cell growth in vitro and zebrafish in vivo. Organic & biomolecular chemistry. 11(39):6680-5
Gorja, D.R., Mukherjee, S., Meda, C.L., Deora, G.S., Lalith Kumar, K., Jain, A., Chaudhari, G.H., Chennubhotla, K.S., Banote, R.K., Kulkarni, P., Parsa, K.V., Mukkanti, K., and Pal, M. (2013) Novel N-indolylmethyl substituted olanzapine derivatives: their design, synthesis and evaluation as PDE4B inhibitors. Organic & biomolecular chemistry. 11(13):2075-2079
Banote, R.K., Koutarapu, S., Chennubhotla, K.S., Chatti, K., and Kulkarni, P. (2013) Oral gabapentin suppresses pentylenetetrazole-induced seizure-like behavior and cephalic field potential in adult zebrafish. Epilepsy & behavior : E&B. 27(1):212-219
Chaudhari, G.H., Chennubhotla, K.S., Chatti, K., and Kulkarni, P. (2013) Optimization of the adult zebrafish ECG method for assessment of drug-induced QTc prolongation. Journal of Pharmacological and Toxicological Methods. 67(2):115-120
Reddy, E.R., Banote, R.K., Chatti, K., Kulkarni, P., and Rajadurai, M.S. (2012) Selective Multicolour Imaging of Zebrafish Muscle Fibres by Using Fluorescent Organic Nanoparticles. Chembiochem : a European journal of chemical biology. 13(13):1889-1894

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