PUBLICATION
Ligand-free MCR for linking quinoxaline framework with a benzimidazole nucleus: a new strategy for the identification of novel hybrid molecules as potential inducers of apoptosis
- Authors
- Sunke, R., Babu, P.V., Yellanki, S., Medishetti, R., Kulkarni, P., Pal, M.
- ID
- ZDB-PUB-140730-16
- Date
- 2014
- Source
- Organic & biomolecular chemistry 12(35): 6800-5 (Journal)
- Registered Authors
- Kulkarni, Pushkar
- Keywords
- none
- MeSH Terms
-
- Animals
- Apoptosis*
- Benzimidazoles/chemistry*
- Catalysis
- Copper/chemistry
- Dose-Response Relationship, Drug
- Drug Design
- Ethylamines/chemistry
- Humans
- Iodides/chemistry
- Ligands
- Microscopy, Fluorescence
- Neoplasms/drug therapy
- Neoplasms/metabolism
- Quinoxalines/chemistry*
- Zebrafish
- PubMed
- 25066016 Full text @ Org. Biomol. Chem.
Citation
Sunke, R., Babu, P.V., Yellanki, S., Medishetti, R., Kulkarni, P., Pal, M. (2014) Ligand-free MCR for linking quinoxaline framework with a benzimidazole nucleus: a new strategy for the identification of novel hybrid molecules as potential inducers of apoptosis. Organic & biomolecular chemistry. 12(35):6800-5.
Abstract
We report a true MCR involving the reaction of N-(prop-2-ynyl)quinoxalin-2-amine derivatives with 2-iodoanilines and tosyl azide in the presence of 10 mol% of CuI and Et3N in DMSO to afford the pre-designed hybrid molecules containing quinoxaline framework linked with a benzimidazole nucleus. The MCR proceeds in the absence of any ligand and/or lateral addition of the catalyst/base affording products within 30 min in good yields, some of which showed encouraging apoptosis inducing properties in zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping