ZFIN ID: ZDB-PUB-130322-2
Suppression of Pu.1 Function results in expanded myelopoiesis in zebrafish
Sun, J., Liu, W., Li, L., Chen, J., Wu, M., Zhang, Y., Leung, A.Y., Zhang, W., Wen, Z., and Liao, W.
Date: 2013
Source: Leukemia   27(9): 1913-7 (Other)
Registered Authors: Li, Li, Zhang, Yiyue
Keywords: none
MeSH Terms:
  • Animals
  • Cell Line
  • Gene Expression Regulation
  • Mutation
  • Myelopoiesis/genetics*
  • Proto-Oncogene Proteins/genetics*
  • Proto-Oncogene Proteins/metabolism
  • Trans-Activators/genetics*
  • Trans-Activators/metabolism
  • Zebrafish/genetics*
  • Zebrafish/metabolism
PubMed: 23455395 Full text @ Leukemia

PU.1 is a member of Ets-family transcription factors, which is indispensable for generating early myeloid progenitors and for the determination of monocytic versus granulocytic lineages during myelopoiesis. Apart from its early function in myelopoiesis, PU.1 is also reported to be involved in leukemogenesis in mice and human. It has been shown that PU.1 expression is downregulated in human acute myeloid leukemia (AML) patients, and PU.1 mutations are found in about 7% of the patients in a study involving 126 AML patients. Likewise, reduction of PU.1 activity leads to AML in mice.