ZFIN ID: ZDB-PERS-140403-1
Zhang, Yiyue
Email: mczhangyy@scut.edu.cn
URL:
Affiliation: Yiyue ZHANG Lab
Address: Division of Cell, Developmental and Integrative Biology, School of Medicine, South China University of Technology Guangzhou, 510006, P.R. China
Country: China
Phone:
Fax:
ORCID ID: 0000-0002-9402-3523


BIOGRAPHY AND RESEARCH INTERESTS
We are interested in developmental biology of hematopoiesis using zebrafish as a model organism.
Our group currently focus on:
(1) Genetic control and molecular regulation of myeloid cell development.
(2) Thrombocyte formation during embryonic development.
(3) The regulatory mechanism of HSC migration in early development.


PUBLICATIONS
Li, J., Meng, P., Zhou, R., Zhang, Y., Lin, Q. (2020) Famciclovir leads to failure of hematopoiesis, but may have the benefit of relieving myeloid expansion in MDS-like zebrafish. Toxicology and applied pharmacology. 410:115334
Yang, R., Zhan, M., Guo, M., Yuan, H., Wang, Y., Zhang, Y., Zhang, W., Chen, S., de The, H., Chen, Z., Zhou, J., Zhu, J. (2020) Yolk sac-derived Pdcd11-positive cells modulate zebrafish microglia differentiation through the NF-κB-Tgfβ1 pathway. Cell death and differentiation. 28(1):170-183
Liu, J., Liao, G., Tu, H., Huang, Y., Peng, T., Xu, Y., Chen, X., Huang, Z., Zhang, Y., Meng, X., Zou, F. (2019) A protective role of autophagy in Pb-induced developmental neurotoxicity in zebrafish. Chemosphere. 235:1050-1058
Wang, Y., Liu, X., Xie, B., Yuan, H., Zhang, Y., Zhu, J. (2019) The NOTCH1-dependent HIF1α/VGLL4/IRF2BP2 oxygen sensing pathway triggers erythropoiesis terminal differentiation. Redox Biology. 28:101313
Xu, M., Ye, Y., Ye, Z., Xu, S., Liu, W., Xu, J., Zhang, Y., Liu, Q., Huang, Z., Zhang, W. (2019) Human BCR/ABL1 induces chronic myeloid leukemia-like disease in zebrafish. Haematologica. 105(3):674-686
Wang, L., Gao, S., Wang, H., Xue, C., Liu, X., Yuan, H., Wang, Z., Chen, S., Chen, Z., de Thé, H., Zhang, Y., Zhang, W., Zhu, J., Zhou, J. (2019) Interferon regulatory factor 2 binding protein 2b regulates neutrophil versus macrophage fate during zebrafish definitive myelopoiesis. Haematologica. 105(2):325-337
Zhang, A., Wu, M., Tan, J., Yu, N., Xu, M., Yu, X., Liu, W., Zhang, Y. (2019) Establishment of a zebrafish hematological disease model induced by 1,4-benzoquinone. Disease models & mechanisms. 12(3):
Chi, Y., Huang, Z., Chen, Q., Xiong, X., Chen, K., Xu, J., Zhang, Y., Zhang, W. (2018) Loss of runx1 function results in B cell immunodeficiency but not T cell in adult zebrafish.. Open Biology. 8(7):
Lian, J., Chen, J., Wang, K., Zhao, L., Meng, P., Yang, L., Wei, J., Ma, N., Xu, J., Zhang, W., Zhang, Y. (2018) Alas1 is essential for neutrophil maturation in zebrafish. Haematologica. 103(11):1785-1795
Zhang, Z., Liu, W., Zhao, L., Huang, Z., Chen, X., Ma, N., Xu, J., Zhang, W., Zhang, Y. (2017) Rb1 promotes T cell maturation from premature apoptosis by inhibiting E2F1. Development (Cambridge, England). 145(1)
Tu, H., Peng, T., Liu, J., Chen, X., Fan, C., Huang, Z., Zhang, Y., Zou, F., Meng, X. (2017) Role of neurexin2a in lead-induced locomotor defect in developing zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 194:167-175
Di, Q., Lin, Q., Huang, Z., Chi, Y., Chen, X., Zhang, W., Zhang, Y. (2017) Zebrafish nephrosin helps host defence against Escherichia coli infection.. Open Biology. 7(8)
Tu, H., Fan, C., Chen, X., Liu, J., Wang, B., Huang, Z., Zhang, Y., Meng, X., Zou, F. (2017) Effects of cadmium, manganese and lead on locomotor activity and neurexin2a expression in zebrafish. Environmental toxicology and chemistry. 36(8):2147-2154
Lin, Q., Zhang, Y., Zhou, R., Zheng, Y., Zhao, L., Huang, M., Zhang, X., Leung, A.Y., Zhang, W., Zhang, Y. (2017) Establishment of a congenital amegakaryocytic thrombocytopenia model and a thrombocyte-specific reporter line in zebrafish. Leukemia. 31(5):1206-1216
Liu, W., Wu, M., Huang, Z., Lian, J., Chen, J., Wang, T., Leung, A.Y., Liao, Y., Zhang, Z., Liu, Q., Yen, K., Lin, S., Zon, L.I., Wen, Z., Zhang, Y., Zhang, W. (2017) c-myb hyperactivity leads to myeloid and lymphoid malignancies in zebrafish. Leukemia. 31(1):222-233
Wang, L., Jiang, W., Lin, Q., Zhang, Y., Zhao, C. (2016) DNA methylation regulates gabrb2 mRNA expression: Developmental variations and disruptions in L-Methionine-induced zebrafish with schizophrenia-like symptoms. Genes, brain, and behavior. 15(8):702-710
Meng, P., Liu, Y., Chen, X., Zhang, W., Zhang, Y. (2016) Zebrafish Cdh5 negatively regulates mobilization of aorta-gonad-mesonephros-derived hematopoietic stem cells. Journal of genetics and genomics = Yi chuan xue bao. 43(10):613-616
Dai, Y., Zhu, L., Huang, Z., Zhou, M., Jin, W., Liu, W., Xu, M., Yu, T., Zhang, Y., Wen, Z., Liao, W., Zhang, W. (2016) Cebpα is essential for the embryonic myeloid progenitor and neutrophil maintenance in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 43(10):593-600
Jin, H., Huang, Z., Chi, Y., Wu, M., Zhou, R., Zhao, L., Xu, J., Zhen, F., Lan, Y., Li, L., Zhang, W., Wen, Z., Zhang, Y. (2016) cMyb acts in parallel and cooperatively with Cebp1 to regulate neutrophil maturation in zebrafish. Blood. 128(3):415-26
Guo, P., Huang, Z., Tao, T., Chen, X., Zhang, W., Zhang, Y., Lin, C. (2015) Zebrafish as a model for studying the developmental neurotoxicity of propofol. Journal of applied toxicology : JAT. 35(12):1511-9
Dai, W., Wang, K., Zheng, X., Chen, X., Zhang, W., Zhang, Y., Hou, J., Liu, L. (2015) High fat plus high cholesterol diet lead to hepatic steatosis in zebrafish larvae: a novel model for screening anti-hepatic steatosis drugs. Nutrition & metabolism. 12:42
Hao, K., Li, Y., Feng, J., Zhang, W., Zhang, Y., Ma, N., Zeng, Q., Pang, H., Wang, C., Xiao, L., He, X. (2015) Ozone promotes regeneration by regulating the inflammatory response in zebrafish. International Immunopharmacology. 28(1):369-75
Wang, K., Fang, X., Ma, N., Lin, Q., Huang, Z., Liu, W., Xu, M., Chen, X., Zhang, W., Zhang, Y. (2015) Myeloperoxidase-deficient Zebrafish show an Augmented Inflammatory Response to Challenge with Candida albicans. Fish & shellfish immunology. 44(1):109-16
He, B.L., Shi, X., Man, C.H., Ma, A.C., Ekker, S.C., Chow, H.C., So, C.W., Choi, W.W., Zhang, W., Zhang, Y., and Leung, A.Y. (2014) Functions of FMS-like tyrosine kinase 3 (flt3) in zebrafish hematopoiesis and its relevance to human acute myeloid leukemia. Blood. 123(16):2518-29
Sun, J., Liu, W., Li, L., Chen, J., Wu, M., Zhang, Y., Leung, A.Y., Zhang, W., Wen, Z., and Liao, W. (2013) Suppression of Pu.1 Function results in expanded myelopoiesis in zebrafish. Leukemia. 27(9):1913-7
Wang, K., Huang, Z., Zhao, L., Liu, W., Chen, X., Meng, P., Lin, Q., Chi, Y., Xu, M., Ma, N., Zhang, Y., and Zhang, W. (2012) Large-scale forward genetic screening analysis of development of hematopoiesis in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 39(9):473-480
Zhang, Y., Jin, H., Li, L., Qin, F.X., and Wen, Z. (2011) cMyb regulates hematopoietic stem/progenitor cell mobilization during zebrafish hematopoiesis. Blood. 118(15):4093-101

NON-ZEBRAFISH PUBLICATIONS