PUBLICATION
Sequential transfer of left-right information during vertebrate embryo development
- Authors
- Raya, A., and Izpisúa Belmonte, J.C.
- ID
- ZDB-PUB-130117-3
- Date
- 2004
- Source
- Current opinion in genetics & development 14(5): 575-581 (Review)
- Registered Authors
- Izpisúa Belmonte, Juan Carlos, Raya, Angel
- Keywords
- none
- MeSH Terms
-
- Animals
- Body Patterning*
- Gene Expression Regulation, Developmental
- Humans
- Mesoderm/metabolism
- Nodal Protein
- Signal Transduction
- Transforming Growth Factor beta/genetics
- Transforming Growth Factor beta/metabolism
- Vertebrates/embryology*
- Vertebrates/metabolism*
- PubMed
- 15380250 Full text @ Curr. Opin. Genet. Dev.
Citation
Raya, A., and Izpisúa Belmonte, J.C. (2004) Sequential transfer of left-right information during vertebrate embryo development. Current opinion in genetics & development. 14(5):575-581.
Abstract
The establishment of left–right asymmetries in the vertebrate embryo is carried out by complex genetic interactions that impart left- or right-sided information to the developing organs and structures. The origin of LR information is still unclear, but recent advances have provided new insights as to how it is relayed to the embryo node, and thereafter to the lateral plate mesoderm. In both steps, signaling by members of the transforming growth factor-β superfamily plays critical roles in amplifying and spreading LR cues, which are reviewed here.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping