ZFIN Person: Raya, Angel

ZFIN ID: ZDB-PERS-020725-22

ZFIN ID: ZDB-PERS-020725-22

Raya, Angel

Email:	araya@idibell.cat
URL:	https://p-cmrc.cat/research/raya-group/
Affiliation:	Raya Lab
Address:	Regenerative Medicine Program Bellvitge Biomedical Research Institute (IDIBELL) Hospital Duran i Reynals, 3rd floor Av. Gran Via 199-203 08908 Hospitalet de Llobregat (Barcelona) Spain
Country:
Phone:	34 93 607 3821
Fax:
ORCID ID:	0000-0003-2189-9775

BIOGRAPHY AND RESEARCH INTERESTS

2020-present Coordinator, Regenerative Medicine Program at Bellvitge Biomedical Research Institute (IDIBELL).
2017-present Director, Program for Translation of Regenerative Medicine in Catalonia (P-CMRC).
2014-2019: Director, Center of Regenerative Medicine in Barcelona, Barcelona, Spain.
2010-2015: Group Leader, Institute for Bioengineering of Catalonia, Barcelona Science Park, Barcelona, Spain.
2008-present: Group Leader, Networking Center of Biomedical Research in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN).
2006-2009: Scientific Coordinator, Center of Regenerative Medicine in Barcelona (CMRB), Barcelona, Spain.
2006-present: ICREA Research Professor.
2004-2006: Senior Research Associate. Gene Expression Laboratory. Salk Institute for Biological Studies, La Jolla, CA, USA. Supervisor: Juan Carlos Izpisúa-Belmonte.
2000-2004: Research Associate. Gene Expression Laboratory. Salk Institute for Biological Studies, La Jolla, CA, USA. Supervisor: Juan Carlos Izpisúa-Belmonte.
1999-2000: Senior Research Associate. Molecular Pathology Unit. Instituto de Investigaciones Citológicas, FVIB. Valencia, Spain. Supervisor: Juan Saus.
1996: Assistant Professor. Department of Physiology, University of Valencia, Spain.
1995-1999: Postdoctoral Research Fellow. Molecular Pathology Unit. Instituto de Investigaciones Citológicas, FVIB. Valencia, Spain. Supervisor: Juan Saus.
1994-1995: Special Project Associate. Peripheral Nerve Center, Department of Neurology, Mayo Clinic, Rochester, MN, USA. Supervisor: Phillip A. Low.
1991-1995: Graduate student. Department of Physiology, University of Valencia, Spain. Supervisor: Joaquín Romá.
1990: MD, University of Valencia, Spain

Research interests:
Our laboratory employs a multipronged approach to address one basic question: How can a discrete and defined degree of developmental potency be imposed onto a somatic cell so that it regains the ability to regenerate a functional tissue or structure? For this purpose, we use in vivo approaches in animal models (zebrafish heart regeneration), as well as cell-based paradigms built around human pluripotent stem cells.

PUBLICATIONS

Garcia-Puig, A., Mosquera, J.L., Jiménez-Delgado, S., García-Pastor, C., Jorba, I., Navajas, D., Canals, F., Raya, A. (2019) Proteomics analysis of extracellular matrix remodeling during zebrafish heart regeneration. Molecular & cellular proteomics : MCP. 18(9):1745-1755

Uroz, M., Garcia-Puig, A., Tekeli, I., Elosegui-Artola, A., Abenza, J.F., Marín-Llauradó, A., Pujals, S., Conte, V., Albertazzi, L., Roca-Cusachs, P., Raya, Á., Trepat, X. (2019) Traction forces at the cytokinetic ring regulate cell division and polyploidy in the migrating zebrafish epicardium. Nature Materials. 18(9):1015-1023

Tekeli, I., Garcia-Puig, A., Notari, M., García-Pastor, C., Aujard, I., Jullien, L., Raya, A. (2017) Fate predetermination of cardiac myocytes during zebrafish heart regeneration. Open Biology. 7(6)

Bedford-Guaus, S.J., Chauvigné, F., Mejía-Ramírez, E., Martí, M., Ventura-Rubio, A., Raya, Á., Cerdà, J., Veiga, A. (2016) Expression of the T85A mutant of zebrafish aquaporin 3b improves post-thaw survival of cryopreserved early mammalian embryos. Zygote (Cambridge, England). 24(6):839-847

Tekeli, I., Aujard, I., Trepat, X., Jullien, L., Raya, A., Zalvidea, D. (2016) Long-term in vivo single-cell lineage tracing of deep structures using three-photon activation.. Light, science & applications. 5:e16084

Sleep, E., Boué, S., Jopling, C., Raya, M., Raya, A., and Izpisúa Belmonte, J.C. (2010) Transcriptomics approach to investigate zebrafish heart regeneration. Journal of cardiovascular medicine (Hagerstown, Md.). 11(5):369-380

Jopling, C., Sleep, E., Raya, M., Martí, M., Raya, A., and Izpisúa Belmonte, J.C. (2010) Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation. Nature. 464(7288):606-609

Raya, A., and Izpisúa Belmonte, J.C. (2008) Insights into the establishment of left-right asymmetries in vertebrates. Birth defects research. Part C, Embryo today : reviews. 84(2):81-94

Ribeiro, I., Kawakami, Y., Buscher, D., Raya, A., Rodriguez-Leon, J., Morita, M., Rodriguez Esteban, C., and Izpisua Belmonte, J.C. (2007) Tbx2 and Tbx3 Regulate the Dynamics of Cell Proliferation during Heart Remodeling. PLoS One. 2(1):e398

Matsui, T., Raya, A., Callol-Massot, C., Kawakami, Y., Oishi, I., Rodriguez-Esteban, C., and Izpisúa Belmonte, J.C. (2007) miles-apart-Mediated regulation of cell-fibronectin interaction and myocardial migration in zebrafish. Nature clinical practice. Cardiovascular medicine. 4(1):S77-S82

Oishi, I., Kawakami, Y., Raya, A., Callol-Massot, C., and Izpisúa Belmonte, J.C. (2006) Regulation of primary cilia formation and left-right patterning in zebrafish by a noncanonical Wnt signaling mediator, duboraya. Nature Genetics. 38(11):1316-1322

Raya, A., and Izpisúa Belmonte, J.C. (2006) Left-right asymmetry in the vertebrate embryo: from early information to higher-level integration. Nature reviews. Genetics. 7(4):283-293

Kawakami, Y., Raya, A., Raya, R.M., Rodriguez-Esteban, C., and Izpisúa Belmonte, J.C. (2005) Retinoic acid signalling links left-right asymmetric patterning and bilaterally symmetric somitogenesis in the zebrafish embryo. Nature. 435(7039):165-171

Matsui, T., Raya, A., Kawakami, Y., Callol-Massot, C., Capdevila, J., Rodriguez-Esteban, C., Izpisúa Belmonte, J.C. (2005) Noncanonical Wnt signaling regulates midline convergence of organ primordia during zebrafish development. Genes & Development. 19(1):164-175

Raya, A., and Izpisúa Belmonte, J.C. (2004) Sequential transfer of left-right information during vertebrate embryo development. Current opinion in genetics & development. 14(5):575-581

Huang, Q., Raya, A., DeJesus, P., Chao, S.H., Quon, K.C., Caldwell, J.S., Chanda, S.K., Izpisúa Belmonte, J.C., and Schultz, P.G. (2004) Identification of p53 regulators by genome-wide functional analysis. Proceedings of the National Academy of Sciences of the United States of America. 101(10):3456-3461

Raya, A., Consiglio, A., Kawakami, Y., Rodriguez-Esteban, C., and Izpisúa Belmonte, J.C. (2004) The zebrafish as a model of heart regeneration. Cloning and stem cells. 6(4):345-351

Timmerman, L.A., Grego-Bessa, J., Raya, A., Bertran, E., Perez-Pomares, J.M., Diez, J., Aranda, S., Palomo, S., McCormick, F., Izpisúa Belmonte, J.C., and De La Pompa, J.L. (2004) Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Genes & Development. 18(1):99-115

Raya, A., Koth, C.M., Büscher, D., Kawakami, Y., Itoh, T., Raya, R.M., Sternick, G., Tsai, H.J., Rodriguez-Esteban, C., and Izpisúa Belmonte, J.C. (2003) Activation of Notch signaling pathway precedes heart regeneration in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. (Suppl. 1) 100:11889-11895

Kawakami, Y., Rodriguez-Leon, J., Koth, C.M., Büscher, D., Itoh, T., Raya, A., Ng, J.K., Rodriguez-Esteban, C., Takahashi, S., Henrique, D., Schwarz, M.F., Asahara, H., and Izpisúa Belmonte, J.C. (2003) MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb. Nature cell biology. 5(6):513-519

Raya, A., Kawakami, Y., Rodriguez-Esteban, C., Büscher, D., Koth, C.M., Itoh, T., Morita, M., Raya, R.M., Dubova, I., Bessa, J.G., de la Pompa, J.L., and Izpisúa Belmonte, J.C. (2003) Notch activity induces Nodal expression and mediates the establishment of left-right asymmetry in vertebrate embryos. Genes & Development. 17(10):1213-1218

Ng, J.K., Kawakami, Y., Büscher, D., Raya, A., Itoh, T., Koth, C.M., Rodriguez-Esteban, C., Rodríguez-León, J., Garrity, D.M., Fishman, M.C., and Izpisúa Belmonte, J.C. (2002) The limb identity gene Tbx5 promotes limb initiation by interacting with Wnt2b and Fgf10. Development (Cambridge, England). 129(22):5161-5170

NON-ZEBRAFISH PUBLICATIONS
- Ferrer-Lorente R, …, Raya A. (2021) Cationic carbosilane dendrimers prevent abnormal alpha-synuclein accumulation in Parkinson’s disease patient-specific dopamine neurons. Biomacromolecules, 22:4582-91.
- Carola G, …, Raya A*, Consiglio A*. (2021) Parkinson’s disease patient-specific neuronal networks carrying the LRRK2 G2019S mutation unveil early functional alterations that predate neurodegeneration. npj Parkinsons Dis, 7:55.
- Valls-Margarit M, …, Raya A. (2019) Engineered macroscale cardiac constructs elicit human myocardial tissue-like functionality. Stem Cell Rep, 13:207-20.
- Carrió M, …, Raya A*, Serra E* (2019) Reprogramming captures the genetic and tumorigenic properties of Neurofibromatosis Type 1 plexiform neurofibromas. Stem Cell Rep, 12:411-26.
- di Domenico A, …, Raya A*, Consiglio A* (2019) Patient-specific iPSC-derived astrocytes contribute to non-cell autonomous neurodegeneration in Parkinson’s disease. Stem Cell Rep, 12:213-29.
- Notari M, …, Raya A. (2018) The local microenvironment limits the regenerative potential of the mouse neonatal heart. Sci Adv, 4:eaao5553.
- Ojosnegros S, …, Raya A*, Fraser SE*. (2017) Eph-ephrin signaling modulated by polymerization and condensation of receptors. Proc Natl Acad Sci USA, 114(50):13188-93.
- Pulecio J, …, Raya A. (2017) CRISPR/Cas9-based engineering of the epigenome. Cell Stem Cell, 21:431-47.
- Pulecio J, …, Raya A. (2016) Direct conversion of fibroblasts to megakaryocyte progenitors. Cell Rep 17(3):671-683.
- Canals I, …, Raya A. (2015) Activity and High-Order Effective Connectivity Alterations in Sanfilippo C Patient-Specific Neuronal Networks. Stem Cell Rep, 5: 546-57.
- Sanchez-Danés A, …, Raya A. (2012) Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson’s disease. EMBO Mol Med, 4:380-395.
- Raya A, …, Izpisúa-Belmonte JC. (2010) A protocol describing the genetic correction of somatic human cells and subsequent generation of iPS cells. Nat Protoc, 5:647-60.
- Raya A, , Belmonte, JC. (2009) Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature, 460:53-9.
- Raya A, Izpisua Belmonte JC. (2006) Left-right in the vertebrate embryo: from early information to higher-level integration. Nat Rev Genet, 7:283-93.
- Raya A, …, Izpisúa Belmonte JC. (2004) Notch activity acts as a sensor for extracellular calcium during vertebrate left-right determination. Nature, 427:121-8.
- Raya A, …, Izpisúa Belmonte JC. (2003) Notch activity induces Nodal expression and mediates the establishment of left-right asymmetry in vertebrate embryos. Genes Dev, 17:1213-8.
- Raya A, …, Saus J. (2000) Goodpasture antigen-binding protein, the kinase that phosphorylates the Goodpasture antigen, is an alternative spliced variant implicated in autoimmune pathogenesis. J Biol Chem, 275:40392-9.
- Raya A, …, Saus J. (1999) Characterization of a novel type of serine/threonine kinase that specifically phosphorylates the human goodpasture antigen. J Biol Chem, 274:12642-9.
- Raya A, …, Romero FJ. (1995) Phenytoin-induced glutathione depletion in rat peripheral nerve. Free Radic Biol Med, 19:665-7.
- Raya A, …, Romá J. (1994) Nerve conduction velocity decrease and synaptic transmission alterations in caffeine-treated rats. Neurotoxicol Teratol, 16:11-5.
- Raya A, …, Romero FJ. (1993) Alterations in the antioxidant defense of peripheral nervous tissue following acute ethanol administration. Biochem Soc Trans, 21:92S.
- Raya A, …, Romá J. (1992) Prevention of the acute neurotoxic effects of phenytoin on rat peripheral nerve by H7, an inhibitor of protein kinase C. Toxicology, 75:249-56.