ZFIN ID: ZDB-PUB-120215-24
Neuronal expression of class 6 semaphorins in zebrafish
Ebert, A.M., Lamont, R.E., Childs, S.J., and McFarlane, S.
Date: 2012
Source: Gene expression patterns : GEP   12(3-4): 117-122 (Journal)
Registered Authors: Childs, Sarah J., Lamont, Ryan
Keywords: zebrafish, semaphorin, gene expression, development, in situ hybridization, neuronal
MeSH Terms:
  • Animals
  • Axons/metabolism*
  • Gene Expression Regulation, Developmental*
  • Mesencephalon/cytology
  • Mesencephalon/metabolism
  • Phylogeny
  • Retinal Ganglion Cells/metabolism
  • Semaphorins/genetics*
  • Semaphorins/metabolism
  • Superior Colliculi/cytology
  • Superior Colliculi/metabolism
  • Zebrafish/embryology
  • Zebrafish/genetics*
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism
PubMed: 22330030 Full text @ Gene Expr. Patterns

Semaphorins are a large family of guidance molecules identified by an extracellular SEMA domain. Classes 1 and 2 are derived from invertebrates, classes 3–7 are vertebrate and class 8 (v) are viral semaphorins. Class 6 semaphorins are reported to have a wide variety of roles including in axon guidance, transcriptional regulation and cancer. Here we report the identification and expression of four class 6 semaphorins (6A, 6Ba, 6Bb and 6Dl) in three stages of larval development in zebrafish (24, 48 and 72 hours postfertilization). Our data indicate that each of the class 6 semaphorins shows a distinct pattern of expression in the developing nervous system that is dynamic over the first 3 days of embryonic development. These data suggest that the individual class 6 semaphorins have diverse roles in nervous system development.