PUBLICATION
Hooked on Zebrafish: Insights into Development and Cancer of Endocrine Tissues
- Authors
- Bourque, C., and Houvras, Y.
- ID
- ZDB-PUB-110609-48
- Date
- 2011
- Source
- Endocrine-related cancer 18(5): R149-64 (Review)
- Registered Authors
- Bourque, Caitlin, Houvras, Yariv
- Keywords
- none
- MeSH Terms
-
- Animals
- Disease Models, Animal*
- Endocrine Gland Neoplasms*
- Endocrine System/anatomy & histology
- Endocrine System/physiology*
- Zebrafish/anatomy & histology
- Zebrafish/physiology*
- PubMed
- 21632806 Full text @ Endocr. Relat. Cancer
Citation
Bourque, C., and Houvras, Y. (2011) Hooked on Zebrafish: Insights into Development and Cancer of Endocrine Tissues. Endocrine-related cancer. 18(5):R149-64.
Abstract
Zebrafish is emerging as a unique model organism for studying cancer genetics and biology. For several decades zebrafish have been used to study vertebrate development, where they have made important contributions to understanding the specification and differentiation programs in many tissues. Recently, zebrafish studies have led to important insights into thyroid development, and have been used to model endocrine cancer. Zebrafish possess a unique set of attributes that make them amenable to forward and reverse genetic approaches. Zebrafish embryos develop rapidly and can be used to study specific cell lineages or the effects of chemicals on pathways or tissue development. Here we review the structure and function of endocrine organs in zebrafish and outline the major achievements in modeling cancer. Our goal is to familiarize readers with the zebrafish as a genetic model system and propose opportunities for endocrine cancer research in zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping