PUBLICATION
Zebrafish behavioural assays of translational relevance for the study of psychiatric disease
- Authors
- Brennan, C.H.
- ID
- ZDB-PUB-110603-28
- Date
- 2011
- Source
- Reviews in the Neurosciences 22(1): 37-48 (Review)
- Registered Authors
- Brennan, Caroline
- Keywords
- addiction, behavioural disorder, cognition, psychiatric disease, schizophrenia, zebrafish
- MeSH Terms
-
- Animals
- Behavior, Animal/physiology*
- Behavioral Research*
- Disease Models, Animal*
- Humans
- Mental Disorders*/diagnosis
- Mental Disorders*/physiopathology
- Mental Disorders*/psychology
- Zebrafish/physiology*
- PubMed
- 21615260 Full text @ Rev. Neurosci.
Citation
Brennan, C.H. (2011) Zebrafish behavioural assays of translational relevance for the study of psychiatric disease. Reviews in the Neurosciences. 22(1):37-48.
Abstract
Understanding the pathogenesis of the complex behavioural disorders that constitute psychiatric disease is a major challenge for biomedical research. Assays in rodents have contributed significantly to our understanding of the neural basis of behavioural disorders and continue to be one of the main focuses for the development of novel therapeutics. Now, owing to their genetic tractability and optical transparency (allowing in vivo imaging of circuit function) and the rapid expansion of genetic tools, zebrafish are becoming increasingly popular for behavioural genetic research. The increased development of behavioural assays in zebrafish raises the possibility of exploiting the advantages of this system to identify molecular mechanisms contributing to behavioural phenotypes associated with psychiatric disorders as well as potential therapeutics. This mini-review describes behavioural paradigms in zebrafish that can be used to address endophenotypes associated with psychiatric disease. The content reflects the interests of the author and covers tests of cognitive functions, response choice and inhibition, social interaction and executive function.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping