ZFIN Person: Brennan, Caroline

ZFIN ID: ZDB-PERS-960805-72

ZFIN ID: ZDB-PERS-960805-72

Brennan, Caroline

Email:	c.h.brennan@qmul.ac.uk
URL:	http://www.qmw.ac.uk/~ugbt800/public_html/CBindex.html
Affiliation:	Brennan Lab
Address:	School of Biological Sciences Queen Mary College University of London Mile End Road London, E1 4NS United Kingdom
Country:	United Kingdom
Phone:	Office: 44-20-7882-3011, Lab: 44-20-7882-5555 ext. 4107
Fax:	44-20-8983-0973
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

During development of a vertebrate embryo a series of inductive interactions and cellular rearrangements establish the body plan. One process that is critical for proper organisation of the body is segmentation of the mesoderm. My laboratory is studying cellular and molecular mechanisms underlying segmentation and differentiation of the mesoderm with an emphasis on cell-cell signalling by members of the Eph family of receptor tyrosine kinases and other signalling molecules such as calcium.

PUBLICATIONS

Antón-Galindo, E., Adel, M.R., García-González, J., Leggieri, A., López-Blanch, L., Irimia, M., Norton, W.H.J., Brennan, C.H., Fernàndez-Castillo, N., Cormand, B. (2024) Pleiotropic contribution of rbfox1 to psychiatric and neurodevelopmental phenotypes in two zebrafish models. Translational psychiatry. 14:9999

Bilardo, R., Traldi, F., Brennan, C.H., Resmini, M. (2023) The Role of Crosslinker Content of Positively Charged NIPAM Nanogels on the In Vivo Toxicity in Zebrafish. Pharmaceutics. 15(7):

Torres-Pérez, J.V., Anagianni, S., Mech, A.M., Havelange, W., García-González, J., Fraser, S.E., Vallortigara, G., Brennan, C.H. (2022) baz1b loss-of-function in zebrafish produces phenotypic alterations consistent with the domestication syndrome. iScience. 26:105704105704

Sheardown, E., Torres-Perez, J.V., Anagianni, S., Fraser, S.E., Vallortigara, G., Butterworth, B., Miletto-Petrazzini, M.E., Brennan, C.H. (2022) Characterizing ontogeny of quantity discrimination in zebrafish. Proceedings. Biological sciences. 289:20212544

Leggieri, A., García-González, J., Torres-Perez, J.V., Havelange, W., Hosseinian, S., Mech, A.M., Keatinge, M., Busch-Nentwich, E.M., Brennan, C.H. (2022) Ankk1 Loss of Function Disrupts Dopaminergic Pathways in Zebrafish. Frontiers in neuroscience. 16:794653

Mech, A.M., Merteroglu, M., Sealy, I.M., Teh, M.T., White, R.J., Havelange, W., Brennan, C.H., Busch-Nentwich, E.M. (2022) Behavioral and Gene Regulatory Responses to Developmental Drug Exposures in Zebrafish. Frontiers in psychiatry. 12:795175

Glazer, L., Brennan, C.H. (2021) Developmental Exposure to Low Concentrations of Methylmercury Causes Increase in Anxiety-Related Behaviour and Locomotor Impairments in Zebrafish. International Journal of Molecular Sciences. 22(20):

Messina, A., Potrich, D., Schiona, I., Sovrano, V.A., Fraser, S.E., Brennan, C.H., Vallortigara, G. (2021) Neurons in the Dorso-Central Division of Zebrafish Pallium Respond to Change in Visual Numerosity. Cerebral cortex (New York, N.Y. : 1991). 32(2):418-428

Ponzoni, L., Melzi, G., Marabini, L., Martini, A., Petrillo, G., Teh, M.T., Torres-Perez, J.V., Morara, S., Gotti, C., Braida, D., Brennan, C.H., Sala, M. (2021) Conservation of mechanisms regulating emotional-like responses on spontaneous nicotine withdrawal in zebrafish and mammals. Progress in neuro-psychopharmacology & biological psychiatry. 111:110334

Evans, J.R., Torres-Pérez, J.V., Miletto Petrazzini, M.E., Riley, R., Brennan, C.H. (2021) Stress reactivity elicits a tissue-specific reduction in telomere length in aging zebrafish (Danio rerio). Scientific Reports. 11:339

Miletto Petrazzini, M.E., Gambaretto, L., Dadda, M., Brennan, C., Agrillo, C. (2021) Are cerebral and behavioural lateralization related to anxiety-like traits in the animal model zebrafish (Danio rerio)?. Laterality. 26(1-2):144-162

Ponzoni, L., Teh, M.T., Torres-Perez, J.V., Brennan, C.H., Braida, D., Sala, M. (2020) Increased Response to 3,4-Methylenedioxymethamphetamine (MDMA) Reward and Altered Gene Expression in Zebrafish During Short- and Long-Term Nicotine Withdrawal. Molecular neurobiology. 58(4):1650-1663

Fontana, B.D., Gibbon, A.J., Cleal, M., Sudwarts, A., Pritchett, D., Miletto Petrazzini, M.E., Brennan, C.H., Parker, M.O. (2020) Moderate early life stress improves adult zebrafish (Danio rerio) working memory but does not affect social and anxiety-like responses. Developmental psychobiology. 63(1):54-64

Messina, A., Potrich, D., Schiona, I., Sovrano, V.A., Fraser, S.E., Brennan, C.H., Vallortigara, G. (2020) Response to change in the number of visual stimuli in zebrafish:A behavioural and molecular study. Scientific Reports. 10:5769

García-González, J., Brock, A.J., Parker, M.O., Riley, R.J., Joliffe, D., Sudwarts, A., Teh, M.T., Busch-Nentwich, E.M., Stemple, D.L., Martineau, A.R., Kaprio, J., Palviainen, T., Kuan, V., Walton, R.T., Brennan, C.H. (2020) Identification of slit3 as a locus affecting nicotine preference in zebrafish and human smoking behaviour. eLIFE. 9:

Daggett, J.M., Brown, V.J., Brennan, C.H. (2018) Food or friends? What motivates zebrafish (Danio Rerio) performing a visual discrimination. Behavioural brain research. 359:190-196

Brock, A.J., Goody, S.M.G., Mead, A.N., Sudwarts, A., Parker, M.O., Brennan, C.H. (2017) Assessing the value of the zebrafish conditioned place preference model for predicting human abuse potential. The Journal of pharmacology and experimental therapeutics. 363(1):66-79

Raimondi, C., Calleja, V., Ferro, R., Fantin, A., Riley, A.M., Potter, B.V., Brennan, C.H., Maffucci, T., Larijani, B., Falasca, M. (2016) A Small Molecule Inhibitor of PDK1/PLCγ1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion. Scientific Reports. 6:26142

Baiamonte, M., Parker, M.O., Vinson, G.P., Brennan, C.H. (2016) Sustained Effects of Developmental Exposure to Ethanol on Zebrafish Anxiety-Like Behaviour. PLoS One. 11:e0148425

Parker, M.O., Evans, A.M., Brock, A.J., Combe, F.J., Teh, M.T., Brennan, C.H. (2016) Moderate alcohol exposure during early brain development increases stimulus-response habits in adulthood. Addiction biology. 21(1):49-60

Martins, V.L., Caley, M.P., Moore, K., Szentpetery, Z., Marsh, S.T., Murrell, D.F., Kim, M.H., Avari, M., McGrath, J.A., Cerio, R., Kivisaari, A., Kähäri, V.M., Hodivala-Dilke, K., Brennan, C.H., Chen, M., Marshall, J.F., O'Toole, E.A. (2015) Suppression of TGFβ and Angiogenesis by Type VII Collagen in Cutaneous SCC. Journal of the National Cancer Institute. 108(1)

Parker, M.O., Brock, A.J., Sudwarts, A., Teh, M.T., Combe, F.J., Brennan, C.H. (2015) Developmental role of acetylcholinesterase in impulse control in zebrafish. Frontiers in behavioral neuroscience. 9:271

Baiamonte, M., Brennan, C.H., Vinson, G.P. (2015) Sustained Action of Developmental Ethanol Exposure on the Cortisol Response to Stress in Zebrafish Larvae and Adults. PLoS One. 10(4):e0124488

Stewart, A.M., Ullmann, J.F., Norton, W.H., Parker, M.O., Brennan, C.H., Gerlai, R., Kalueff, A.V. (2015) Molecular psychiatry of zebrafish. Molecular psychiatry. 20(1):2-17

Parker, M.O., Annan, L.V., Kanellopoulos, A.H., Brock, A.J., Combe, F.J., Baiamonte, M., Teh, M.T., Brennan, C.H. (2014) The utility of zebrafish to study the mechanisms by which ethanol affects social behavior and anxiety during early brain development. Progress in neuro-psychopharmacology & biological psychiatry. 55:94-100

Proulx, M.J., Parker, M.O., Tahir, Y., Brennan, C.H. (2014) Parallel Mechanisms for Visual Search in Zebrafish. PLoS One. 9:e111540

CichoD, M.A., Szentpetery, Z., Caley, M.P., Papadakis, E.S., Mackenzie, I.C., Brennan, C.H., and O'Toole, E.A. (2014) The receptor tyrosine kinase Axl regulates cell-cell adhesion and stemness in cutaneous squamous cell carcinoma. Oncogene. 33(32):4185-92

Parker, M.O., Brock, A.J., Sudwarts, A., and Brennan, C.H. (2014) Atomoxetine reduces anticipatory responding in a 5-choice serial reaction time task for adult zebrafish. Psychopharmacology. 231(13):2671-9

Parker, M.O., Brock, A.J., Millington, M.E., and Brennan, C.H. (2013) Behavioural Phenotyping of Casper Mutant and 1-Pheny-2-Thiourea Treated Adult Zebrafish. Zebrafish. 10(4):466-71

Parker, M.O., Ife, D., Ma, J., Pancholi, M., Smeraldi, F., Straw, C., and Brennan, C.H. (2013) Development and automation of a test of impulse control in zebrafish. Frontiers in Systems Neuroscience. 7:65

Parker, M.O., Brock, A.J., Walton, R.T., and Brennan, C.H. (2013) The role of zebrafish (Danio rerio) in dissecting the genetics and neural circuits of executive function. Frontiers in neural circuits. 7:63

Barry, S., Chelala, C., Lines, K., Sunamura, M., Wang, A., Marelli-Berg, F.M., Brennan, C., Lemoine, N.R., and Crnogorac-Jurcevic, T. (2013) S100P is a metastasis-associated gene that facilitates transendothelial migration of pancreatic cancer cells. Clinical & experimental metastasis. 30(3):251-264

Parker, M.O., Gaviria, J., Haigh, A., Millington, M.E., Brown, V.J., Combe, F.J., and Brennan, C.H. (2012) Discrimination reversal and attentional sets in zebrafish (Danio rerio). Behavioural brain research. 232(1):264-268

Parker, M.O., Millington, M., Combe, F., and Brennan, C.H. (2012) Development and implementation of a three-choice serial reaction time task for zebrafish (Danio rerio). Behavioural brain research. 227(1):73-80

Parker, M.O., Millington, M.E., Combe, F.J., and Brennan, C.H. (2012) Housing Conditions Differentially Affect Physiological and Behavioural Stress Responses of Zebrafish, as well as the Response to Anxiolytics. PLoS One. 7(4):e34992

Wu, H.H., Brennan, C., and Ashworth, R. (2011) Ryanodine receptors, a family of intracellular calcium ion channels, are expressed throughout early vertebrate development. BMC research notes. 4(1):541

Jobe, K., Brennan, C.H., Motevalli, M., Goldup, S.M., and Watkinson, M. (2011) Modular 'click' sensors for zinc and their application in vivo. Chemical communications (Cambridge, England). 47(21):6036-6038

Brennan, C.H. (2011) Zebrafish behavioural assays of translational relevance for the study of psychiatric disease. Reviews in the Neurosciences. 22(1):37-48

Brennan, C., Dosch, R., Haramis, A.P., Luckenbacher, T., Martinez-Morales, J.R., Moro, E., Polok, B., Ramesh, T.M., Russell, C., Argenton, F., and Strähle, U. (2010) Report of the European Zebrafish Principal Investigator Meeting in Padua, Italy, March 18-22, 2010. Zebrafish. 7(3):305-310

Kily, L.J., Cowe, Y.C., Hussain, O., Patel, S., McElwaine, S., Cotter, F.E., and Brennan, C.H. (2008) Gene expression changes in a zebrafish model of drug dependency suggest conservation of neuro-adaptation pathways. The Journal of experimental biology. 211(Pt 10):1623-1634

Brennan, C., Mangoli, M., Dyer, C.E., Ashworth R. (2005) Acetylcholine and calcium signalling regulates muscle fibre formation in the zebrafish embryo. Journal of Cell Science. 118(22):5181-5190

Ashworth, R., and Brennan, C. (2005) Use of transgenic zebrafish reporter lines to study calcium signalling in development. Briefings in functional genomics & proteomics. 4(2):186-193

Barrios, A., Poole, R.J., Durbin, L., Brennan, C., Holder, N., and Wilson, S.W. (2003) Eph/Ephrin signaling regulates the mesenchymal-to-epithelial transition of the paraxial mesoderm during somite morphogenesis. Current biology : CB. 13(18):1571-1582

Brennan, C., Amacher, S.L., and Currie, P.D. (2002) Somitogenesis. Results and problems in cell differentiation. 40:271-297

Chan, J., Mably, J.D., Serluca, F.C., Chen, J.-N., Goldstein, N.B., Thomas, M.C., Cleary, J.A., Brennan, C., Fishman, M.C., and Roberts, T.M. (2001) Morphogenesis of prechordal plate and notochord requires intact Eph/Ephrin B signaling. Developmental Biology. 234(2):470-482

Cooke, J.E., Moens, C.B., Roth, L.W., Durbin, L., Shiomi, K., Brennan, C., Kimmel, C.B., Wilson, S.W., and Holder, N. (2001) Eph signalling functions downstream of Val to regulate cell sorting and boundary formation in the caudal hindbrain. Development (Cambridge, England). 128(4):571-580

Brennan, C. (2001) Eph receptor signalling and formation of the somites in zebrafish. In Proceedings of the NATO Advanced Research Workshop on The Origin and Fate of Somites, E. J. Sanders, J. W. Lash and C. P. Ordahl, eds., Series I - Life and Behavioural Sciences, Amsterdam: IOS Press. :225-232

Durbin, L., Sordino, P., Barrios, A., Gering, M., Thisse, C., Thisse, B., Brennan, C., Green, A., Wilson, S., and Holder, N. (2000) Anteroposterior patterning is required within segments for somite boundary formation in developing zebrafish. Development (Cambridge, England). 127(8):1703-1713

Celik, A., Brennan, C., and Korsching, S.I. (2000) Eph/ephrin in the zebrafish olfactory system. The European journal of neuroscience. 12:496

Picker, A., Brennan, C., Reifers, F., Clarke, J.D., Holder, N., and Brand, M. (1999) Requirement for the zebrafish mid-hindbrain boundary in midbrain polarisation, mapping and confinement of the retinotectal projection. Development (Cambridge, England). 126(13):2967-2978

Heisenberg, C.P., Brennan, C., and Wilson, S.W. (1999) Zebrafish aussicht mutant embryos exhibit widespread overexpression of ace (fgf8) and coincident defects in CNS development. Development (Cambridge, England). 126(10):2129-2140

Durbin, L., Brennan, C., Shiomi, K., Cooke, J., Barrios, A., Shanmugalingam, S., Guthrie, B., Lindberg, R., and Holder, N. (1998) Eph signaling is required for segmentation and differentiation of the somites. Genes & Development. 12:3096-3109

Wilson, S.W., C. Brennan, Macdonald, R., M. Brand, and N. Holder (1997) Analysis of axon tract formation in the zebrafish brain: the role of territories of gene expression and their boundaries. Cell and tissue research. 290(2):189-196

Macdonald, R., Scholes, J., Strähle, U., Brennan, C., Holder, N., Brand, M., and Wilson, S.W. (1997) The Pax protein Noi is required for commissural axon pathway formation in the rostral forebrain. Development (Cambridge, England). 124(12):2397-2408

Brennan, C., Monschau, B., Lindberg, R., Guthrie, B., Drescher, U., Bonhoeffer, F., and Holder, N. (1997) Two Eph receptor tyrosine kinase ligands control axon growth and may be involved in the creation of the retinotectal map in the zebrafish. Development (Cambridge, England). 124(3):655-664

Holder, N., Brennan, C., Cooke, J., Durbin, L., and Qiling, X. (1996) The role of signalling through Eph receptors in patterning the zebrafish neural plate. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 14:59

NON-ZEBRAFISH PUBLICATIONS
Bell. JD, Barnard. ML, Parkes. HG, Thomas. EL, Brennan. CH, Cunnane. SC, Dagnelie. PC (1996) Effects of n-3 fatty acids on the NMR profile of plasma lipoproteins. J Lipid Res 37(8): 1664-1674.

Verhoeven.AJM, Woods.A, Brennan.CH, Hawley.SA, Hardie.DG, Scott.J, Beri.RK, Carling.D. (1995) The AMP-activated protein-kinase gene is highly expressed in rat skeletal-muscle - alternative splicing and tissue distribution of the messenger-RNA European Journal of Biochemistry, 228, (2) : 236-243

Carling.D, Aguan.K, Woods.A, Verhoeven.AJM, Beri.RK, Brennan.CH, Sidebottom.C, Davison.MD, Scott.J (1994). Mammalian amp-activated protein-kinase is homologous to yeast and plant protein-kinases involved in the regulation of carbon metabolism. Journal of Biological Chemistry, 269, (15):11442-11448.

Littleton. J., Brennan. C. (1993) Adaptive changes in numbers of calcium channels in drug dependence. Biochem Soc Symp 50:193-203

Brennan.CH, Littleton.JM. (1991) Chronic exposure to anxiolytic drugs, working by different mechanisms causes up-regulation of dihydropyridine binding-sites on cultured bovine adrenal chromaffin cells. Neuropharmacology, 30, (2):199-205

Brennan.CH, Crabbe.J, Littleton.JM.(1990) Genetic-regulation of dihydropyridine-sensitive calcium channels in brain may determine susceptibility to physical-dependence on alcohol. Neuropharmacology, 29, (5) : 429-432

Brennan.CH, Littleton.JM (1990) 2nd messengers involved in genetic-regulation of the number of calcium channels in bovine adrenal chromaffin cells in culture. Neuropharmacology, 29(7): 689-693

Brennan.CH, Lewis.A, Littleton.JM (1989). Membrane-receptors involved in up-regulation of calcium channels in bovine adrenal chromaffin cells chronically exposed to ethanol Neuropharmacology, 28, (12) :1303-1307

Harper.JC, Brennan.CH, Littleton.JM (1989) Genetic up-regulation of calcium channels in a cellular-model of ethanol dependence. Neuropharmacology, 28 (12) :1299-1302

Brennan.CH,Guppy.L.J., Littleton.JM (1989) Chronic exposure to ethanol increases dihydropyridine-sensitive calcium channels in excitable cells Annals of the New York Academy of Sciences, 560, (JUN):467-469

Littleton. JM, Harper. JC, Brennan. CH, Guppy.LJ. (1988). Adaptation in membrane Ca2+ channels as a basis for alcohol-related pathology. Australian Drug and Alcohol Reviews. 7 :35-38

Hudspith.MJ, Brennan.CH, Charles.S, Littleton.JM.(1987) Dihydropyridine-sensitive-Ca2+ -channels and inositol phospholipid- metabolism in ethanol physical-dependence Annals of the New York Academy of Sciences, 492, (.APR):.156-170