PUBLICATION
Distinct signalling pathways regulate sprouting angiogenesis from the dorsal aorta and the axial vein
- Authors
- Wiley, D.M., Kim, J.D., Hao, J., Hong, C.C., Bautch, V.L., and Jin, S.W.
- ID
- ZDB-PUB-110602-1
- Date
- 2011
- Source
- Nature cell biology 13(6): 686-92 (Journal)
- Registered Authors
- Hong, Charles, Jin, Suk-Won, Kim, Jun-Dae
- Keywords
- none
- MeSH Terms
-
- Reverse Transcriptase Polymerase Chain Reaction
- Immunohistochemistry
- Zebrafish/embryology*
- Neovascularization, Physiologic*
- Aorta/embryology
- Signal Transduction*
- Animals
- Veins/embryology
- PubMed
- 21572418 Full text @ Nat. Cell Biol.
Citation
Wiley, D.M., Kim, J.D., Hao, J., Hong, C.C., Bautch, V.L., and Jin, S.W. (2011) Distinct signalling pathways regulate sprouting angiogenesis from the dorsal aorta and the axial vein. Nature cell biology. 13(6):686-92.
Abstract
Angiogenesis, the formation of new blood vessels from pre-existing vessels, is critical to most physiological processes and many pathological conditions. During zebrafish development, angiogenesis expands the axial vessels into a complex vascular network that is necessary for efficient oxygen delivery. Although the dorsal aorta and the axial vein are spatially juxtaposed, the initial angiogenic sprouts from these vessels extend in opposite directions, indicating that distinct cues may regulate angiogenesis of the axial vessels. We found that angiogenic sprouts from the dorsal aorta are dependent on vascular endothelial growth factor A (Vegf-A) signalling, and do not respond to bone morphogenetic protein (Bmp) signals. In contrast, sprouts from the axial vein are regulated by Bmp signalling independently of Vegf-A signals, indicating that Bmp is a vein-specific angiogenic cue during early vascular development. Our results support a paradigm whereby different signals regulate distinct programmes of sprouting angiogenesis from the axial vein and dorsal aorta, and indicate that signalling heterogeneity contributes to the complexity of vascular networks.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping