PUBLICATION
Modular 'click' sensors for zinc and their application in vivo
- Authors
- Jobe, K., Brennan, C.H., Motevalli, M., Goldup, S.M., and Watkinson, M.
- ID
- ZDB-PUB-110519-5
- Date
- 2011
- Source
- Chemical communications (Cambridge, England) 47(21): 6036-6038 (Journal)
- Registered Authors
- Brennan, Caroline
- Keywords
- none
- MeSH Terms
-
- Animals
- Crystallography, X-Ray
- Heterocyclic Compounds/chemical synthesis
- Heterocyclic Compounds/chemistry*
- Microscopy, Fluorescence
- Molecular Conformation
- Zebrafish/metabolism
- Zinc/chemistry*
- PubMed
- 21528144 Full text @ Chem. Commun. (Camb.)
Citation
Jobe, K., Brennan, C.H., Motevalli, M., Goldup, S.M., and Watkinson, M. (2011) Modular 'click' sensors for zinc and their application in vivo. Chemical communications (Cambridge, England). 47(21):6036-6038.
Abstract
Although the central role that zinc plays in many biological processes and important disease states is now well-established, there remains a pressing need to develop an absolute understanding of the underlying biology of zinc trafficking in terms of its dynamic and quantitative processing in specific organelles. Here we describe the modular synthesis of zinc sensors using a 'click' approach and demonstrate the applicability of our new sensors in vivo using a zebrafish model.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping