ZFIN ID: ZDB-PUB-110110-14
A structural and functional ground plan for neurons in the hindbrain of zebrafish
Kinkhabwala, A., Riley, M., Koyama, M., Monen, J., Satou, C., Kimura, Y., Higashijima, S.I., and Fetcho, J.
Date: 2011
Source: Proceedings of the National Academy of Sciences of the United States of America   108(3): 1164-1169 (Journal)
Registered Authors: Fetcho, Joseph R., Higashijima, Shin-ichi
Keywords: interneuron, locomotion, recruitment, topography
MeSH Terms:
  • Age Factors
  • Animals
  • Animals, Genetically Modified
  • Body Patterning/physiology*
  • Calcium/metabolism
  • Electrophysiology
  • Interneurons/cytology
  • Interneurons/metabolism*
  • Microscopy, Confocal
  • Models, Neurological*
  • Nerve Net*
  • Neurotransmitter Agents/metabolism*
  • Rhombencephalon/anatomy & histology*
  • Rhombencephalon/physiology
  • Zebrafish/anatomy & histology*
  • Zebrafish/physiology
PubMed: 21199947 Full text @ Proc. Natl. Acad. Sci. USA
The vertebrate hindbrain contains various sensory-motor networks controlling movements of the eyes, jaw, head, and body. Here we show that stripes of neurons with shared neurotransmitter phenotype that extend throughout the hindbrain of young zebrafish reflect a broad underlying structural and functional patterning. The neurotransmitter stripes contain cell types with shared gross morphologies and transcription factor markers. Neurons within a stripe are stacked systematically by extent and location of axonal projections, input resistance, and age, and are recruited along the axis of the stripe during behavior. The implication of this pattern is that the many networks in hindbrain are constructed from a series of neuronal components organized into stripes that are ordered from top to bottom according to a neuron's age, structural and functional properties, and behavioral roles. This simple organization probably forms a foundation for the construction of the networks underlying the many behaviors produced by the hindbrain.