PUBLICATION

Emergence of traveling waves in the zebrafish segmentation clock

Authors
Ishimatsu, K., Takamatsu, A., and Takeda, H.
ID
ZDB-PUB-100420-34
Date
2010
Source
Development (Cambridge, England)   137(10): 1595-1599 (Journal)
Registered Authors
Takeda, Hiroyuki
Keywords
Fgf, her1, Oscillation, Segmentation clock, Traveling waves, Zebrafish
MeSH Terms
  • Animals
  • Animals, Genetically Modified
  • Basic Helix-Loop-Helix Transcription Factors/genetics*
  • Basic Helix-Loop-Helix Transcription Factors/metabolism
  • Biological Clocks/genetics
  • Biological Clocks/physiology*
  • Body Patterning/genetics*
  • Body Patterning/physiology
  • Cleavage Stage, Ovum/metabolism
  • Cleavage Stage, Ovum/physiology
  • Embryo, Nonmammalian
  • Fibroblast Growth Factors/genetics
  • Fibroblast Growth Factors/metabolism
  • Fibroblast Growth Factors/physiology
  • Gene Expression Regulation, Developmental*
  • Models, Biological
  • Signal Transduction
  • Somites/embryology
  • Somites/metabolism
  • Zebrafish/embryology*
  • Zebrafish/genetics
  • Zebrafish/metabolism
  • Zebrafish/physiology
  • Zebrafish Proteins/genetics*
  • Zebrafish Proteins/metabolism
  • Zebrafish Proteins/physiology
PubMed
20392739 Full text @ Development
Abstract
The spatial and temporal periodicity of somite formation is controlled by the segmentation clock, in which numerous cells cyclically express hairy-related transcriptional repressors with a posterior-to-anterior phase delay, creating 'traveling waves' of her1 expression. In zebrafish, the first traveling wave buds off from the synchronous oscillation zone in the blastoderm margin. Here we show that the emergence of a traveling wave coincides with the anterior expansion of Fgf signaling and that transplanted Fgf8b-soaked beads induce ectopic traveling waves. We thus propose that as development proceeds, the activity of Fgf signaling gradually expands anteriorly, starting from the margin, so that cells initiate her1 oscillation with a posterior-to-anterior phase delay. Furthermore, we suggest that Fgf has an essential role in establishing the period gradient that is required for the her1 spatial oscillation pattern at the emergence of the traveling wave.
Genes / Markers
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Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping