PUBLICATION

Dermal morphogenesis controls lateral line patterning during postembryonic development of teleost fish

Authors
Wada, H., Ghysen, A., Satou, C., Higashijima, S.I., Kawakami, K., Hamaguchi, S., and Sakaizumi, M.
ID
ZDB-PUB-100223-53
Date
2010
Source
Developmental Biology   340(2): 583-594 (Journal)
Registered Authors
Ghysen, Alain, Higashijima, Shin-ichi, Kawakami, Koichi, Wada, Hironori
Keywords
Lateral line, Neuromast, Postembryonic development, Dermal bone, Opercle, scale, Zebrafish, Medaka
MeSH Terms
  • Animals
  • Animals, Genetically Modified
  • Body Patterning*
  • Bone and Bones/embryology
  • Dermis/cytology
  • Dermis/growth & development
  • Embryo, Nonmammalian
  • Immunohistochemistry
  • In Situ Hybridization
  • Lateral Line System/cytology
  • Lateral Line System/growth & development*
  • Mechanoreceptors/cytology
  • Microinjections
  • Microscopy, Video
  • Models, Biological
  • Morphogenesis*
  • Oligonucleotides, Antisense/metabolism
  • Oryzias/embryology
  • Oryzias/growth & development*
  • Species Specificity
  • Zebrafish/embryology
  • Zebrafish/growth & development*
PubMed
20171200 Full text @ Dev. Biol.
Abstract
The lateral line system displays highly divergent patterns in adult teleost fish. The mechanisms underlying this variability are poorly understood. Here, we demonstrate that the lateral line mechanoreceptor, the neuromast, gives rise to a series of accessory neuromasts by a serial budding process during postembryonic development in zebrafish. We also show that accessory neuromast formation is highly correlated to the development of underlying dermal structures such as bones and scales. Abnormalities in opercular bone morphogenesis, in endothelin 1-knockdown embryos, is accompanied by stereotypic errors in neuromast budding and positioning, further demonstrating the tight correlation between the patterning of neuromasts and of the underlying dermal bones. In medaka, where scales form between peridermis and opercular bones, the lateral line displays a scale-specific pattern which is never observed in zebrafish. These results strongly suggest a control of postembryonic neuromast patterns by underlying dermal structures. This dermal control may explain some aspects of the evolution of lateral line patterns.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes