PUBLICATION

Phylogeny of the teashirt-related zinc finger (tshz) gene family and analysis of the developmental expression of tshz2 and tshz3b in the zebrafish

Authors
Santos, J.S., Fonseca, N.A., Vieira, C.P., Vieira, J., and Casares, F.
ID
ZDB-PUB-100202-10
Date
2010
Source
Developmental Dynamics : an official publication of the American Association of Anatomists   239(3): 1010-1018 (Journal)
Registered Authors
Casares, Fernando, Santos, Joana
Keywords
tshz gene family, phylogeny, expression, zebrafish, meis, pax6
MeSH Terms
  • Zebrafish
  • Time Factors
  • Paired Box Transcription Factors/metabolism
  • Animals
  • Brain/embryology
  • Eye Proteins/metabolism
  • Gene Expression Profiling*
  • Gene Expression Regulation, Developmental*
  • Repressor Proteins/metabolism
  • Retina/embryology
  • Evolution, Molecular
  • Zebrafish Proteins/metabolism*
  • Phylogeny
  • Spinal Cord/embryology
  • Homeodomain Proteins/metabolism
  • Transcription Factors/metabolism*
  • Neurons/metabolism
  • Zinc Fingers
(all 18)
PubMed
20108322 Full text @ Dev. Dyn.
Abstract
The tshz genes comprise a family of evolutionarily conserved transcription factors. However, despite the major role played by Drosophila tsh during the development of the fruit fly, the expression and function of other tshz genes have been analyzed in a very limited set of organisms and, therefore, our current knowledge of these genes is still fragmentary. In this study, we perform detailed phylogenetic analyses of the tshz genes, identify the members of this gene family in zebrafish and describe the developmental expressions of two of them, tshz2 and tshz3b, and compare them with meis1, meis2.1, meis2.2, pax6a, and pax6b expression patterns. The expression patterns of these genes define a complex set of coexpression domains in the developing zebrafish brain where their gene products have the potential to interact.
Genes / Markers
Figures
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Expression
Phenotype
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Mutations / Transgenics
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Human Disease / Model
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Sequence Targeting Reagents
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Fish
Fish
AB
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Antibodies
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Orthology
Gene Orthology
tshz1
tshz2
tshz3a
tshz3b
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Engineered Foreign Genes
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Mapping
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