ZFIN ID: ZDB-PUB-090914-43
Genetic dissection of myelinated axons in zebrafish
Monk, K.R., and Talbot, W.S.
Date: 2009
Source: Current opinion in neurobiology   19(5): 486-490 (Review)
Registered Authors: Monk, Kelly, Talbot, William S.
Keywords: none
MeSH Terms:
  • Animals
  • Axons/physiology*
  • Genetic Techniques
  • Models, Genetic
  • Myelin Sheath/genetics*
  • Myelin Sheath/physiology*
  • Nerve Fibers, Myelinated/physiology*
  • Neuroglia/physiology
  • Zebrafish/genetics*
  • Zebrafish/physiology*
PubMed: 19740648 Full text @ Curr. Opin. Neurobiol.
In the vertebrate nervous system, the myelin sheath allows for rapid and efficient conduction of action potentials along axons. Despite the essential function of myelin, many questions remain unanswered about the mechanisms that govern the development of myelinated axons. The fundamental properties of myelin are widely shared among vertebrates, and the zebrafish has emerged as a powerful system to study myelination in vivo. This review will highlight recent advances from genetic screens in zebrafish, including the discovery of the role of kif1b in mRNA localization in myelinating oligodendrocytes.