ZFIN Person: Monk, Kelly

ZFIN ID: ZDB-PERS-061103-2

Monk, Kelly

Email:	monk@ohsu.edu
URL:	https://www.ohsu.edu/xd/research/centers-institutes/vollum/faculty/monklab.cfm
Affiliation:	Monk Lab
Address:	Vollum Institute, L474 Oregon Health & Science University 3181 S.W. Sam Jackson Pk. Rd. Portland, Oregon 97239
Country:	United States
Phone:	503-494-2976
Fax:
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Li, J., Miramontes, T.G., Czopka, T., Monk, K.R. (2024) Synaptic input and Ca²⁺ activity in zebrafish oligodendrocyte precursor cells contribute to myelin sheath formation. Nature Neuroscience. 27(2):219-231

Chen, J., Stork, T., Kang, Y., Nardone, K.A.M., Auer, F., Farrell, R.J., Jay, T.R., Heo, D., Sheehan, A., Paton, C., Nagel, K.I., Schoppik, D., Monk, K.R., Freeman, M.R. (2023) Astrocyte growth is driven by the Tre1/S1pr1 phospholipid-binding G protein-coupled receptor. Neuron. 112(1):93-112.e10

Fazal, S.V., Mutschler, C., Chen, C.Z., Turmaine, M., Chen, C.Y., Hsueh, Y.P., Ibañez-Grau, A., Loreto, A., Casillas-Bajo, A., Cabedo, H., Franklin, R.J.M., Barker, R.A., Monk, K.R., Steventon, B.J., Coleman, M.P., Gomez-Sanchez, J.A., Arthur-Farraj, P. (2023) SARM1 detection in myelinating glia: sarm1/Sarm1 is dispensable for PNS and CNS myelination in zebrafish and mice. Frontiers in Cellular Neuroscience. 17:11583881158388

Häberlein, F., Mingardo, E., Merten, N., Schulze Köhling, N.K., Reinoß, P., Simon, K., Japp, A., Nagarajan, B., Schrage, R., Pegurier, C., Gillard, M., Monk, K.R., Odermatt, B., Kostenis, E., Gomeza, J. (2022) Humanized zebrafish as a tractable tool for in vivo evaluation of pro-myelinating drugs. Cell chemical biology. 29(10):1541-1555.e7

Nagai, J., Yu, X., Papouin, T., Cheong, E., Freeman, M.R., Monk, K.R., Hastings, M.H., Haydon, P.G., Rowitch, D., Shaham, S., Khakh, B.S. (2020) Behaviorally consequential astrocytic regulation of neural circuits. Neuron. 109(4):576-596

Gray, R.S., Gonzalez, R., Ackerman, S.D., Minowa, R., Griest, J.F., Bayrak, M.N., Troutwine, B., Canter, S., Monk, K.R., Sepich, D.S., Solnica-Krezel, L. (2020) Postembryonic screen for mutations affecting spine development in zebrafish. Developmental Biology. 471:18-33

Chen, J., Poskanzer, K.E., Freeman, M.R., Monk, K.R. (2020) Live-imaging of astrocyte morphogenesis and function in zebrafish neural circuits. Nature Neuroscience. 23(10):1297-1306

Leon, K., Cunningham, R.L., Riback, J.A., Feldman, E., Li, J., Sosnick, T.R., Zhao, M., Monk, K.R., Araç, D. (2020) Structural basis for adhesion G protein-coupled receptor Gpr126 function. Nature communications. 11:194

Bradley, E.C., Cunningham, R.L., Wilde, C., Morgan, R.K., Klug, E.A., Letcher, S.M., Schöneberg, T., Monk, K.R., Liebscher, I., Petersen, S.C. (2019) In vivo identification of small molecules mediating Gpr126/Adgrg6 signaling during Schwann cell development. Annals of the New York Academy of Sciences. 1456(1):44-63

Cunningham, R.L., Herbert, A.L., Harty, B.L., Ackerman, S.D., Monk, K.R. (2018) Mutations in dock1 disrupt early Schwann cell development. Neural Development. 13:17

Giera, S., Luo, R., Ying, Y., Ackerman, S.D., Jeong, S.J., Stoveken, H.M., Folts, C.J., Welsh, C.A., Tall, G.G., Stevens, B., Monk, K.R., Piao, X. (2018) Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells. eLIFE. 7

Ackerman, S.D., Luo, R., Poitelon, Y., Mogha, A., Harty, B.L., D'Rozario, M., Sanchez, N.E., Lakkaraju, A.K.K., Gamble, P., Li, J., Qu, J., MacEwan, M.R., Ray, W.Z., Aguzzi, A., Feltri, M.L., Piao, X., Monk, K.R. (2018) GPR56/ADGRG1 regulates development and maintenance of peripheral myelin. The Journal of experimental medicine. 215(3):941-961

Cunningham, R.L., Monk, K.R. (2018) Whole Mount In Situ Hybridization and Immunohistochemistry for Zebrafish Larvae. Methods in molecular biology (Clifton, N.J.). 1739:371-384

Cunningham, R.L., Monk, K.R. (2018) Live Imaging of Schwann Cell Development in Zebrafish. Methods in molecular biology (Clifton, N.J.). 1739:401-405

Cunningham, R.L., Monk, K.R. (2018) Transmission Electron Microscopy for Zebrafish Larvae and Adult Lateral Line Nerve. Methods in molecular biology (Clifton, N.J.). 1739:385-400

Herbert, A.L., Fu, M.M., Drerup, C.M., Gray, R.S., Harty, B.L., Ackerman, S.D., O'Reilly-Pol, T., Johnson, S.L., Nechiporuk, A.V., Barres, B.A., Monk, K.R. (2017) Dynein/dynactin is necessary for anterograde transport of Mbp mRNA in oligodendrocytes and for myelination in vivo.. Proceedings of the National Academy of Sciences of the United States of America. 114:E9153-E9162

Sanchez, N.E., Harty, B.L., O'Reilly-Pol, T., Ackerman, S.D., Herbert, A.L., Holmgren, M., Johnson, S.L., Gray, R.S., Monk, K.R. (2017) Whole Genome Sequencing-Based Mapping and Candidate Identification of Mutations from Fixed Zebrafish Tissue. G3 (Bethesda). 7(10):3415-3425

Drerup, C.M., Herbert, A.L., Monk, K.R., Nechiporuk, A.V. (2017) Regulation of mitochondria-dynactin interaction and mitochondrial retrograde transport in axons. eLIFE. 6

Küffer, A., Lakkaraju, A.K., Mogha, A., Petersen, S.C., Airich, K., Doucerain, C., Marpakwar, R., Bakirci, P., Senatore, A., Monnard, A., Schiavi, C., Nuvolone, M., Grosshans, B., Hornemann, S., Bassilana, F., Monk, K.R., Aguzzi, A. (2016) The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6. Nature. 536(7617):464-8

Ackerman, S.D., Monk, K.R. (2016) The scales and tales of myelination: using zebrafish and mouse to study myelinating glia. Brain research. 1641(Pt A):79-91

Liebscher, I., Monk, K.R., Schöneberg, T. (2015) How to wake a giant. Oncotarget. 6:23038-9

Petersen, S.C., Luo, R., Liebscher, I., Giera, S., Jeong, S.J., Mogha, A., Ghidinelli, M., Feltri, M.L., Schöneberg, T., Piao, X., Monk, K.R. (2015) The adhesion GPCR GPR126 has distinct, domain-dependent functions in Schwann cell development mediated by interaction with laminin-211. Neuron. 85:755-69

Liebscher, I., Schön, J., Petersen, S.C., Fischer, L., Auerbach, N., Demberg, L.M., Mogha, A., Cöster, M., Simon, K.U., Rothemund, S., Monk, K.R., Schöneberg, T. (2015) Erratum to: A Tethered Agonist within the Ectodomain Activates the Adhesion G Protein-Coupled Receptors GPR126 and GPR133. Cell Reports. 10:1021

Harty, B.L., Krishnan, A., Sanchez, N.E., Schiöth, H.B., Monk, K.R. (2015) Defining the gene repertoire and spatiotemporal expression profiles of adhesion G protein-coupled receptors in zebrafish. BMC Genomics. 16:62

Ackerman, S.D., Garcia, C., Piao, X., Gutmann, D.H., Monk, K.R. (2015) The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Gα12/13 and RhoA. Nature communications. 6:6122

Liebscher, I., Schön, J., Petersen, S.C., Fischer, L., Auerbach, N., Demberg, L.M., Mogha, A., Cöster, M., Simon, K., Rothemund, S., Monk, K.R., Schöneberg, T. (2014) A Tethered Agonist within the Ectodomain Activates the Adhesion G Protein-Coupled Receptors GPR126 and GPR133. Cell Reports. 9(6):2018-26

Patra, C., Monk, K.R., Engel, F.B. (2014) The multiple signaling modalities of adhesion G protein-coupled receptor GPR126 in development. Receptors & clinical investigation. 1:79

Shiau, C.E., Monk, K.R., Joo, W., and Talbot, W.S. (2013) An Anti-inflammatory NOD-like Receptor Is Required for Microglia Development. Cell Reports. 5(5):1342-1352

Patra, C., van Amerongen, M.J., Ghosh, S., Ricciardi, F., Sajjad, A., Novoyatleva, T., Mogha, A., Monk, K.R., Mühlfeld, C., and Engel, F.B. (2013) Organ-specific function of adhesion G protein-coupled receptor GPR126 is domain-dependent. Proceedings of the National Academy of Sciences of the United States of America. 110(42):16898-16903

Monk, K.R., Voas, M.G., Franzini-Armstrong, C., Hakkinen, I.S., and Talbot, W.S. (2013) Mutation of sec63 in zebrafish causes defects in myelinated axons and liver pathology. Disease models & mechanisms. 6(1):135-145

Monk, K.R., and Talbot, W.S. (2009) Genetic dissection of myelinated axons in zebrafish. Current opinion in neurobiology. 19(5):486-490

Monk, K.R., Naylor, S.G., Glenn, T.D., Mercurio, S., Perlin, J.R., Dominguez, C., Moens, C.B., and Talbot, W.S. (2009) A G protein-coupled receptor is essential for Schwann cells to initiate myelination. Science (New York, N.Y.). 325(5946):1402-1405

NON-ZEBRAFISH PUBLICATIONS