ZFIN ID: ZDB-PUB-090616-42
Transcriptome analysis of the zebrafish pineal gland
Toyama, R., Chen, X., Jhawar, N., Aamar, E., Epstein, J., Reany, N., Alon, S., Gothilf, Y., Klein, D.C., and Dawid, I.B.
Date: 2009
Source: Developmental dynamics : an official publication of the American Association of Anatomists   238(7): 1813-1826 (Journal)
Registered Authors: Aamar, Emil, Dawid, Igor B., Epstein, Jonathan, Gothilf, Yoav, Klein, David C., Toyama, Reiko
Keywords: pineal gland, epiphysis, zebrafish, circadian rhythm, microarray
Microarrays: GEO:GSE13371
MeSH Terms:
  • Animals
  • Brain/metabolism
  • Circadian Rhythm/genetics
  • Cluster Analysis
  • Eye Proteins/genetics
  • Eye Proteins/metabolism
  • Gene Expression Profiling*
  • Gene Expression Regulation, Developmental
  • Oligonucleotide Array Sequence Analysis
  • Photoperiod
  • Pineal Gland/growth & development
  • Pineal Gland/metabolism*
  • Zebrafish/genetics*
  • Zebrafish/growth & development
  • Zebrafish/metabolism
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism
  • Zebrafish Proteins/physiology
PubMed: 19504458 Full text @ Dev. Dyn.
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ABSTRACT
The zebrafish pineal gland (epiphysis) is a site of melatonin production, contains photoreceptor cells, and functions as a circadian clock pace maker. Here, we have used microarray technology to study the zebrafish pineal transcriptome. Analysis of gene expression at three larval and two adult stages revealed a highly dynamic transcriptional profile, revealing many genes that are highly expressed in the zebrafish pineal gland. Statistical analysis of the data based on Gene Ontology annotation indicates that many transcription factors are highly expressed during larval stages, whereas genes dedicated to phototransduction are preferentially expressed in the adult. Furthermore, several genes were identified that exhibit day/night differences in expression. Among the multiple candidate genes suggested by these data, we note the identification of a tissue-specific form of the unc119 gene with a possible role in pineal development.
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