PUBLICATION
Neural patterning and CNS functions of wnt in zebrafish
- Authors
- Dorsky, R.I.
- ID
- ZDB-PUB-090106-27
- Date
- 2008
- Source
- Methods in molecular biology (Clifton, N.J.) 469: 301-315 (Chapter)
- Registered Authors
- Dorsky, Richard
- Keywords
- Wnt, zebrafish, patterning, neurogenesis, CNS
- MeSH Terms
-
- Animals
- Body Patterning/physiology*
- Cell Differentiation
- Central Nervous System/anatomy & histology
- Central Nervous System/embryology*
- Central Nervous System/physiology*
- Embryonic Induction/physiology
- Morphogenesis/physiology
- Neurons/cytology
- Neurons/physiology
- Phenotype
- Signal Transduction/physiology
- Wnt Proteins/genetics
- Wnt Proteins/metabolism*
- Zebrafish/anatomy & histology*
- Zebrafish/embryology*
- Zebrafish/physiology
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- PubMed
- 19109717 Full text @ Meth. Mol. Biol.
Citation
Dorsky, R.I. (2008) Neural patterning and CNS functions of wnt in zebrafish. Methods in molecular biology (Clifton, N.J.). 469:301-315.
Abstract
Wnt signaling plays several important roles in the development of the zebrafish central nervous system (CNS). This chapter outlines both the known and postulated roles of Wnts from the earliest step of neural plate induction to relatively late events such as axon pathfinding and synaptogenesis. The common tools useful for examining Wnt function and nervous system development in zebrafish are first reviewed. Examples are then provided for specific phenotypes resulting from gain and loss of Wnt activity at multiple developmental stages. Finally, specific assays and reagents that can be used to investigate the function of novel Wnt pathway components in CNS development are listed.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping