ZFIN ID: ZDB-PERS-970430-22
Dorsky, Richard
Email: richard.dorsky@neuro.utah.edu
URL: http://www.neuro.utah.edu/labs/dorsky/index.html
Affiliation: Dorsky Lab
Address: Department of Neurobiology and Anatomy University of Utah 427 Wintrobe 20 North 1900 East Salt Lake City, UT 84132-3401 USA
Phone: (801) 581-6073
Fax: (801) 581-4233


Ph.D., Biology, University of California, San Diego, 1996.
B.A., Molecular Biology, University of California, Berkeley, 1990.


Functions of Wnt signaling in vertebrate CNS development.

Vasudevan, D., Liu, Y.C., Barrios, J.P., Wheeler, M.K., Douglass, A.D., Dorsky, R.I. (2021) Regenerated interneurons integrate into locomotor circuitry following spinal cord injury. Experimental neurology. 342:113737
Hutcheson, D.A., Xie, Y., Figueroa, P., Dorsky, R.I. (2020) A transgene targeted to the zebrafish nkx2.4b locus drives specific GFP expression and disrupts thyroid development. Developmental Dynamics : an official publication of the American Association of Anatomists. 249(11):1387-1393
Schredelseker, T., Veit, F., Dorsky, R.I., Driever, W. (2020) Bsx Is Essential for Differentiation of Multiple Neuromodulatory Cell Populations in the Secondary Prosencephalon. Frontiers in neuroscience. 14:525
Cornell, R., Dorsky, R.I. (2017) Zebrafish as models for developmental disease & repair. Developmental Dynamics : an official publication of the American Association of Anatomists. 246:867
Xie, Y., Kaufmann, D., Moulton, M.J., Panahi, S., Gaynes, J.A., Watters, H.N., Zhou, D., Xue, H.H., Fung, C.M., Levine, E.M., Letsou, A., Brennan, K.C., Dorsky, R.I. (2017) Lef1-dependent hypothalamic neurogenesis inhibits anxiety. PLoS Biology. 15:e2002257
Eisenhoffer, G.T., Slattum, G., Ruiz, O.E., Otsuna, H., Bryan, C.D., Lopez, J., Wagner, D.S., Bonkowsky, J.L., Chien, C.B., Dorsky, R.I., Rosenblatt, J. (2017) A toolbox to study epidermal cell types in zebrafish. Journal of Cell Science. 130(1):269-277
McPherson, A.D., Barrios, J.P., Luks-Morgan, S.J., Manfredi, J.P., Bonkowsky, J.L., Douglass, A.D., Dorsky, R.I. (2016) Motor Behavior Mediated by Continuously Generated Dopaminergic Neurons in the Zebrafish Hypothalamus Recovers after Cell Ablation. Current biology : CB. 26(2):263-9
Duncan, R.N., Xie, Y., McPherson, A.D., Taibi, A.V., Bonkowsky, J.L., Douglass, A.D., Dorsky, R.I. (2016) Hypothalamic radial glia function as self-renewing neural progenitors in the absence of Wnt/ß-catenin signaling. Development (Cambridge, England). 143(1):45-53
Duncan, R.N., Panahi, S., Piotrowski, T., Dorsky, R.I. (2015) Identification of Wnt Genes Expressed in Neural Progenitor Zones during Zebrafish Brain Development. PLoS One. 10:e0145810
May, M., Hwang, K.S., Miles, J., Williams, C., Niranjan, T., Kahler, S.G., Chiurazzi, P., Steindl, K., van der Spek, P.J., Swagemakers, S., Mueller, J., Stefl, S., Alexov, E., Ryu, J.I., Choi, J.H., Kim, H.T., Tarpey, P., Neri, G., Holloway, L., Skinner, C., Stevenson, R.E., Dorsky, R.I., Wang, T., Schwartz, C.E., Kim, C.H. (2015) ZC4H2, an XLID Gene, is Required for the Generation of a Specific Subset of CNS Interneurons. Human molecular genetics. 24(17):4848-61
Briona, L.K., Poulain, F.E., Mosimann, C., Dorsky, R.I. (2015) Wnt/ß-catenin signaling Is required for radial glial neurogenesis following spinal cord injury. Developmental Biology. 403(1):15-21
Otsuna, H., Hutcheson, D., Duncan, R., McPherson, A., Scoresby, A., Gaynes, B., Tong, Z., Fujimoto, E., Kwan, K., Chien, C., Dorsky, R. (2015) High-resolution analysis of CNS expression patterns in zebrafish Gal4 enhancer-trap lines. Developmental Dynamics : an official publication of the American Association of Anatomists. 244(6):785-96
Butko, E., Distel, M., Pouget, C., Weijts, B., Kobayashi, I., Ng, K., Mosimann, C., Poulain, F.E., McPherson, A., Ni, C.W., Stachura, D.L., Del Cid, N., Espín-Palazón, R., Lawson, N.D., Dorsky, R., Clements, W.K., Traver, D. (2015) Gata2b is a restricted early regulator of hemogenic endothelium in the zebrafish embryo. Development (Cambridge, England). 142:1050-61
Hutcheson, D., Otsuna, H., Chien, C.B., Dorsky, R. (2014) Enhancer Trap Mutants Gal4 Project. ZFIN Direct Data Submission.
Briona, L.K., Dorsky, R.I. (2014) Radial glial progenitors repair the zebrafish spinal cord following transection. Experimental neurology. 256C:81-92
Briona, L.K., Dorsky, R.I. (2014) Spinal cord transection in the larval zebrafish. Journal of visualized experiments : JoVE. (87)
Wehner, D., Cizelsky, W., Vasudevaro, M.D., Özhan, G., Haase, C., Kagermeier-Schenk, B., Röder, A., Dorsky, R.I., Moro, E., Argenton, F., Kühl, M., and Weidinger, G. (2014) Wnt/β-Catenin Signaling Defines Organizing Centers that Orchestrate Growth and Differentiation of the Regenerating Zebrafish Caudal Fin. Cell Reports. 6(3):467-481
Nguyen, T.K., Tran, V.M., Venkataswamy, S., Eriksson, I., Kojima, A., Koketsu, M., Loganathan, D., Kjellén, L., Dorsky, R.I., Chien, C.B., and Kuberan, B. (2013) Dimerized glycosaminoglycan chains increase FGF signaling during zebrafish development. ACS Chemical Biology. 8(5):939-48
Kruse-Bend, R., Rosenthal, J., Quist, T.S., Veien, E.S., Fuhrmann, S., Dorsky, R.I., and Chien, C.B. (2012) Extraocular ectoderm triggers dorsal retinal fate during optic vesicle evagination in zebrafish. Developmental Biology. 371(1):57-65
Wang, X., Kopinke, D., Lin, J., McPherson, A.D., Duncan, R.N., Otsuna, H., Moro, E., Hoshijima, K., Grunwald, D.J., Argenton, F., Chien, C.B., Murtaugh, L.C., and Dorsky, R.I. (2012) Wnt signaling regulates postembryonic hypothalamic progenitor differentiation. Developmental Cell. 23(3):624-636
Bonner, J., Letko, M., Nikolaus, O.B., Krug, L., Cooper, A., Chadwick, B., Conklin, P., Lim, A., Chien, C.B., and Dorsky, R.I. (2012) Midline crossing is not required for subsequent pathfinding decisions in commissural neurons. Neural Development. 7(1):18
Lin, J., Wang, X., and Dorsky, R.I. (2011) Progenitor expansion in apc mutants is mediated by Jak/Stat signaling. BMC Developmental Biology. 11(1):73
Gribble, S.L., Nikolaus, O.B., Carver, M.S., Hoshijima, K., and Dorsky, R.I. (2009) Chromosomal position mediates spinal cord expression of a dbx1a enhancer. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(11):2929-2935
Wang, X., Lee, J.E., and Dorsky, R.I. (2009) Identification of wnt-responsive cells in the zebrafish hypothalamus. Zebrafish. 6(1):49-58
Gribble, S.L., Kim, H.S., Bonner, J., Wang, X., and Dorsky, R.I. (2009) Tcf3 inhibits spinal cord neurogenesis by regulating sox4a expression. Development (Cambridge, England). 136(5):781-789
Veien, E.S., Rosenthal, J.S., Kruse-Bend, R.C., Chien, C.B., and Dorsky, R.I. (2008) Canonical Wnt signaling is required for the maintenance of dorsal retinal identity. Development (Cambridge, England). 135(24):4101-4111
Bonkowsky, J.L., Wang, X., Fujimoto, E., Lee, J.E., Chien, C.B., and Dorsky, R.I. (2008) Domain-specific regulation of foxP2 CNS expression by lef1. BMC Developmental Biology. 8:103
Russek-Blum, N., Gutnick, A., Nabel-Rosen, H., Blechman, J., Staudt, N., Dorsky, R.I., Houart, C., and Levkowitz, G. (2008) Dopaminergic neuronal cluster size is determined during early forebrain patterning. Development (Cambridge, England). 135(20):3401-3413
McFarland, K.A., Topczewska, J.M., Weidinger, G., Dorsky, R.I., and Appel, B. (2008) Hh and Wnt signaling regulate formation of olig2(+) neurons in the zebrafish cerebellum. Developmental Biology. 318(1):162-171
Clark, A.M., Yun, S., Veien, E.S., Wu, Y.Y., Chow, R.L., Dorsky, R.I., and Levine, E.M. (2008) Negative regulation of Vsx1 by its paralog Chx10/Vsx2 is conserved in the vertebrate retina. Brain research. 1192(1):99-113
Bonner, J., Gribble, S.L., Veien, E.S., Nikolaus, O.B., Weidinger, G., and Dorsky, R.I. (2008) Proliferation and patterning are mediated independently in the dorsal spinal cord downstream of canonical Wnt signaling. Developmental Biology. 313(1):398-407
Dorsky, R.I. (2008) Neural patterning and CNS functions of wnt in zebrafish. Methods in molecular biology (Clifton, N.J.). 469:301-315
Gribble, S.L., Nikolaus, O.B., and Dorsky, R.I. (2007) Regulation and function of Dbx genes in the zebrafish spinal cord. Developmental Dynamics : an official publication of the American Association of Anatomists. 236(12):3472-3483
Nyholm, M.K., Wu, S.F., Dorsky, R.I., and Grinblat, Y. (2007) The zebrafish zic2a-zic5 gene pair acts downstream of canonical Wnt signaling to control cell proliferation in the developing tectum. Development (Cambridge, England). 134(4):735-746
Lee, J.E., Wu, S.F., Goering, L.M., and Dorsky, R.I. (2006) Canonical Wnt signaling through Lef1 is required for hypothalamic neurogenesis. Development (Cambridge, England). 133(22):4451-4461
Veien, E.S., Grierson, M.J., Saund, R.S., and Dorsky, R.I. (2005) Expression pattern of zebrafish tcf7 suggests unexplored domains of Wnt/beta-catenin activity. Developmental Dynamics : an official publication of the American Association of Anatomists. 233(1):233-239
Lewis, J.L., Bonner, J., Modrell, M., Ragland, J.W., Moon, R.T., Dorsky, R.I., and Raible, D.W. (2004) Reiterated Wnt signaling during zebrafish neural crest development. Development (Cambridge, England). 131(6):1299-1308
Dorsky, R.I., Itoh, M., Moon, R.T., and Chitnis, A. (2003) Two tcf3 genes cooperate to pattern the zebrafish brain. Development (Cambridge, England). 130(9):1937-1947
Dorsky, R.I., Sheldahl, L.C., and Moon, R.T. (2002) A transgenic Lef1/beta-catenin-dependent reporter is expressed in spatially restricted domains throughout zebrafish development. Developmental Biology. 241(2):229-237
Dorsky, R.I., Raible, D.W., and Moon, R.T. (2001) Wnt function in the developing zebrafish nervous system. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 15(5):A1071
Dorsky, R.I., Raible, D.W., and Moon, R.T. (2000) Signaling pathways and neural crest fate specification. BioEssays : news and reviews in molecular, cellular and developmental biology. 22:708-716
Dorsky, R.I., Raible, D.W., and Moon, R.T. (2000) Direct regulation of nacre, a zebrafish MITF homolog required for pigment cell formation, by the Wnt pathway. Genes & Development. 14(2):158-162
Dorsky, R.I., Snyder, A., Cretekos, C.J., Grunwald, D.J., Geisler, R., Haffter, P., Moon, R.T., and Raible, D.W. (1999) Maternal and embryonic expression of zebrafish lef1. Mechanisms of Development. 86(1-2):147-150
Dorsky, R.I., Moon, R.T., and Raible, D.W. (1998) Control of neural crest cell fate by the Wnt signalling pathway. Nature. 396:370-373