|ZFIN ID: ZDB-PUB-081121-13|
Alpha2 macroglobulin-like is essential for liver development in zebrafish
Hong, S.K., and Dawid, I.B.
|Source:||PLoS One 3(11): e3736 (Journal)|
|Registered Authors:||Dawid, Igor B., Hong, Sung-Kook|
|Keywords:||Embryos, Zebrafish, Pancreas, Untranslated regions, Gastrointestinal tract, Hematoxylin staining, In situ hybridization, Xenopus|
|PubMed:||19011686 Full text @ PLoS One|
Hong, S.K., and Dawid, I.B. (2008) Alpha2 macroglobulin-like is essential for liver development in zebrafish. PLoS One. 3(11):e3736.
ABSTRACTBACKGROUND: Alpha 2 Macroglobulin family members have been studied extensively with respect to their roles in physiology and human disease including innate immunity and Alzheimer's disease, but little is known about a possible role in liver development loss-of-function in model systems.
PRINCIPAL FINDINGS: We report the isolation of the zebrafish alpha2 macroglobulin-like (A2ML) gene and its specific expression in the liver during differentiation. Morpholino-based knock-down of A2ML did not block the initial formation of the liver primordium, but inhibited liver growth and differentiation.
SIGNIFICANCE: This report on A2ML function in zebrafish development provides the first evidence for a specific role of an A2M family gene in liver formation during early embryogenesis in a vertebrate.