Melanocyte regeneration reveals mechanisms of adult stem cell regulation
- O'Reilly-Pol, T., and Johnson, S.L.
- Seminars in cell & developmental biology 20(1): 117-124 (Review)
- Registered Authors
- Johnson, Stephen L., O'Reilly-Pol, Thomas
- Regeneration, Melanocyte stem cell (MSC), Zebrafish, Kit
- MeSH Terms
- Adult Stem Cells/cytology*
- Adult Stem Cells/metabolism
- Cell Differentiation*
- Metamorphosis, Biological
- Models, Biological
- 18950723 Full text @ Sem. Cell Dev. Biol.
O'Reilly-Pol, T., and Johnson, S.L. (2009) Melanocyte regeneration reveals mechanisms of adult stem cell regulation. Seminars in cell & developmental biology. 20(1):117-124.
Utilization of adult stem cells in regenerative therapies may require a thorough understanding of the mechanisms that establish, recruit and renew the stem cell, promote the differentiation of its daughters, or how the stem cell is repressed by its target tissue. Regeneration of melanocytes in the regenerating zebrafish caudal fin, or following larval melanocyte-specific ablation, or recruitment of new melanocytes during pigment pattern metamorphosis each provides evidence for melanocyte stem cells (MSCs) that support the melanocyte pigment pattern. We discuss the mechanisms of MSC regulation provided from analysis of normal or mutant regeneration in each of these systems, including the implications drawn from evidence that regeneration does not simply recapitulate ontogenetic development. These results suggest that analysis of melanocyte regeneration in zebrafish will provide a fine scale dissection of mechanisms establishing or regulating adult stem cells.
Genes / Markers
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Engineered Foreign Genes