PUBLICATION
Zebrafish: a predictive model for assessing drug-induced toxicity
- Authors
- McGrath, P., and Li, C.Q.
- ID
- ZDB-PUB-080515-1
- Date
- 2008
- Source
- Drug discovery today 13(9-10): 394-401 (Review)
- Registered Authors
- McGrath, Patricia
- Keywords
- none
- MeSH Terms
-
- Animals
- Chemical and Drug Induced Liver Injury
- Drug-Related Side Effects and Adverse Reactions*
- Heart Diseases/chemically induced
- Models, Animal*
- Neurotoxins/toxicity
- Teratogens/toxicity
- Toxicity Tests
- Zebrafish*
- PubMed
- 18468556 Full text @ Drug Discov. Today
Citation
McGrath, P., and Li, C.Q. (2008) Zebrafish: a predictive model for assessing drug-induced toxicity. Drug discovery today. 13(9-10):394-401.
Abstract
The zebrafish model organism is increasingly used for assessing drug toxicity and safety and numerous studies confirm that mammalian and zebrafish toxicity profiles are strikingly similar. This transparent vertebrate offers several compelling experimental advantages, including convenient drug delivery and low cost. Although full validation will require assessment of a large number of compounds from diverse classes, zebrafish can be used to eliminate potentially unsafe compounds rapidly in the early stages of drug development and to prioritize compounds for further preclinical and clinical studies. Adaptation of conventional instrumentation combined with new nanotechnology developments will continue to expand use of zebrafish for drug screening.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping