ZFIN Person: McGrath, Patricia

ZFIN ID: ZDB-PERS-021126-1

ZFIN ID: ZDB-PERS-021126-1

McGrath, Patricia

Email:	pat@phylonix.com
URL:	http://www.phylonix.com
Affiliation:	Phylonix Pharmaceuticals, Inc.
Address:	Suite 300 100 Inman Street Cambridge, MA 02139 USA
Country:
Phone:	(617) 441-6700
Fax:	(617) 441-6766
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

Phylonix is a contract research organization providing in vivo zebrafish assays for drug screening. The company has developed general and organ specific toxicity tests, as well as other bioassays such as apoptosis and angiogenesis. In addition, the company conducts custom designed studies, such as gene function analyses using gene knockdown approaches.

PUBLICATIONS

McGrath, P., and Seng, W.L. (2013) Use of zebrafish apoptosis assays for preclinical drug discovery. Expert opinion on drug discovery. 8(10):1191-202

McGrath, P., Seng, W.L., Willett, C., and Augustine, K.A. (2008) Determination of LD50 and assessment of drug induced developmental toxicity in zebrafish. Journal of Pharmacological and Toxicological Methods. 58(2):150

McGrath, P., and Li, C.Q. (2008) Zebrafish: a predictive model for assessing drug-induced toxicity. Drug discovery today. 13(9-10):394-401

Parng, C., Roy, N.M., Ton, C., Lin, Y., and McGrath, P. (2007) Neurotoxicity assessment using zebrafish. Journal of Pharmacological and Toxicological Methods. 55(1):103-112

Parng, C., Ton, C., Lin, Y.X., Roy, N.M., and McGrath, P. (2006) A zebrafish assay for identifying neuroprotectants in vivo. Neurotoxicology and teratology. 28(4):509-516

Haldi, M., Ton, C., Seng, W.L., and McGrath, P. (2006) Human melanoma cells transplanted into zebrafish proliferate, migrate, produce melanin, form masses and stimulate angiogenesis in zebrafish. Angiogenesis. 9(3):139-151

Parng, C., Anderson, N., Ton, C., and McGrath, P. (2004) Zebrafish apoptosis assays for drug discovery. The Zebrafish: Cellular and Developmental Biology,2nd Ed. Methods Cell Biol.. 76:75-85

Seng, W.L., Eng, K., Lee, J., and McGrath, P. (2004) Use of a monoclonal antibody specific for activated endothelial cells to quantitate angiogenesis in vivo in zebrafish after drug treatment. Angiogenesis. 7(3):243-253

Ma, C., Parng, C.L., Seng, W.L., Zhang, C., Willett, C., and McGrath, P. (2003) Zebrafish – An in vivo model for drug screening. Innovations in Pharmaceutical Technologies. Nov. 2003:38-45

Parng, C., Seng, W.L., Semino, C., and McGrath, P. (2002) Zebrafish: a preclinical model for drug screening. Assay and drug development technologies. 1(1 Pt 1):41-8

NON-ZEBRAFISH PUBLICATIONS