PUBLICATION

Transgenic zebrafish expressing fluorescent proteins in central nervous system neurons

Authors
Higashijima, S.I.
ID
ZDB-PUB-080501-10
Date
2008
Source
Development, growth & differentiation   50(6): 407-413 (Review)
Registered Authors
Higashijima, Shin-ichi
Keywords
BAC, GFP, neural circuits, transgenic, zebrafish
MeSH Terms
  • Animals
  • Animals, Genetically Modified*
  • Central Nervous System/metabolism*
  • Chromosomes, Artificial, Bacterial
  • Fluorescent Dyes/pharmacology
  • Genetic Techniques
  • Green Fluorescent Proteins/metabolism
  • Luminescent Proteins/metabolism
  • Luminescent Proteins/pharmacology
  • Models, Biological
  • Models, Genetic
  • Neurons/metabolism
  • Transgenes
  • Zebrafish/genetics*
PubMed
18445066 Full text @ Dev. Growth Diff.
Abstract
Zebrafish is a powerful model system for investigations of vertebrate neural development. The animal has also become an important model for studies of neuronal function. Both in developmental and functional studies, transgenic zebrafish expressing fluorescent proteins in central nervous system neurons have been playing important roles. We review here the methods for producing transgenic zebrafish. Recent advances in transposon- or bacterial artificial chromosome-based transgenesis greatly facilitate the creation of useful lines. We also present our study on alx-positive neurons to reveal how transgenic zebrafish expressing fluorescent proteins in a specific class of neurons can be used to investigate their development and function.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes