PUBLICATION
Insertional mutagenesis strategies in zebrafish
- Authors
- Sivasubbu, S., Balciunas, D., Amsterdam, A.,and Ekker, S.C.
- ID
- ZDB-PUB-071210-16
- Date
- 2007
- Source
- Genome biology 8(1): S9 (Review)
- Registered Authors
- Amsterdam, Adam, Balciunas, Darius, Ekker, Stephen C., Sivasubbu, Sridhar
- Keywords
- none
- MeSH Terms
-
- Animals
- DNA Transposable Elements
- Embryonic Stem Cells/metabolism
- Mutagenesis, Insertional/methods*
- Retroviridae
- Zebrafish/genetics*
- Zebrafish/virology
- PubMed
- 18047701 Full text @ Genome Biol.
Citation
Sivasubbu, S., Balciunas, D., Amsterdam, A.,and Ekker, S.C. (2007) Insertional mutagenesis strategies in zebrafish. Genome biology. 8(1):S9.
Abstract
We review here some recent developments in the field of insertional mutagenesis in zebrafish. We highlight the advantages and limitations of the rich body of retroviral methodologies, and we focus on the mechanisms and concepts of new transposon-based mutagenesis approaches under development, including prospects for conditional 'gene trapping' and 'gene breaking' approaches.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping