ZFIN Person: Amsterdam, Adam

ZFIN ID: ZDB-PERS-970114-4

ZFIN ID: ZDB-PERS-970114-4

Amsterdam, Adam

Email:	aha@mit.edu
URL:
Affiliation:	Lees Lab
Address:	Koch Institute for Integrative Cancer Research at MIT 77 Massachusetts Avenue 76-461 Cambridge MA 02139 USA
Country:	United States
Phone:	617 252 1972
Fax:
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Phelps, G.B., Hagen, H.R., Amsterdam, A., Lees, J.A. (2022) MITF deficiency accelerates GNAQ-driven uveal melanoma. Proceedings of the National Academy of Sciences of the United States of America. 119:e2107006119

Perez, D.E., Henle, A.M., Amsterdam, A., Hagen, H.R., Lees, J.A. (2018) Uveal melanoma driver mutations in GNAQ/11 yield numerous changes in melanocyte biology. Pigment cell & melanoma research. 31(5):604-613

Anderson, N.M., Li, D., Peng, H.L., Laroche, F.J., Mansour, M.R., Gjini, E., Aioub, M., Helman, D.J., Roderick, J.E., Cheng, T., Harrold, I., Samaha, Y., Meng, L., Amsterdam, A., Neuberg, D.S., Denton, T.T., Sanda, T., Kelliher, M.A., Singh, A., Look, A.T., Feng, H. (2016) The TCA cycle transferase DLST is important for MYC-mediated leukemogenesis. Leukemia. 30(6):1365-74

Wu, Q., Zhang, J., Koh, W., Yu, Q., Zhu, X., Amsterdam, A., Davis, G.E., Arnaout, M.A., Xiong, J.W. (2015) Talin1 is required for cardiac Z-disk stabilization and endothelial integrity in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 29(12):4989-5005

Percival, S.M., Thomas, H.R., Amsterdam, A., Carroll, A.J., Lees, J.A., Yost, H.J., Parant, J.M. (2015) Variations in sister chromatid cohesion dysfunction in esco2 mutant zebrafish reflects the phenotypic diversity of Roberts Syndrome. Disease models & mechanisms. 8(8):941-55

Jevtov, I., Samuelsson, T., Yao, G., Amsterdam, A., Ribbeck, K. (2014) Zebrafish as a model to study live mucus physiology. Scientific Reports. 4:6653

Zhang, G., Hoersch, S., Amsterdam, A., Whittaker, C.A., Beert, E., Catchen, J.M., Farrington, S., Postlethwait, J.H., Legius, E., Hopkins, N., and Lees, J.A. (2013) Comparative oncogenomic analysis of copy number alterations in human and zebrafish tumors enables cancer driver discovery. PLoS Genetics. 9(8):e1003734

Mosimann, C., Puller, A.C., Lawson, K.L., Tschopp, P., Amsterdam, A., and Zon, L.I. (2013) Site-directed zebrafish transgenesis into single landing sites with the phiC31 integrase system. Developmental Dynamics : an official publication of the American Association of Anatomists. 242(8):949-63

Thakur, P.C., Stuckenholz, C., Rivera, M.R., Davison, J.M., Yao, J.K., Amsterdam, A., Sadler, K.C., and Bahary, N. (2011) Lack of De novo phosphatidylinositol synthesis leads to endoplasmic reticulum stress and hepatic steatosis in cdipt-deficient zebrafish. Hepatology (Baltimore, Md.). 54(2):452-62

Amsterdam, A., Varshney, G.K., and Burgess, S.M. (2011) Retroviral-mediated Insertional Mutagenesis in Zebrafish. Methods in cell biology. 104:59-82

Barresi, M.J., Burton, S., Dipietrantonio, K., Amsterdam, A., Hopkins, N., and Karlstrom, R.O. (2010) Essential genes for astroglial development and axon pathfinding during zebrafish embryogenesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(10):2603-2618

Zhang, G., Hoersch, S., Amsterdam, A., Whittaker, C.A., Lees, J.A., and Hopkins, N. (2010) Highly aneuploid zebrafish malignant peripheral nerve sheath tumors have genetic alterations similar to human cancers. Proceedings of the National Academy of Sciences of the United States of America. 107(39):16940-16945

Insinna, C., Baye, L.M., Amsterdam, A., Besharse, J.C., and Link, B.A. (2010) Analysis of a zebrafish dync1h1 mutant reveals multiple functions for cytoplasmic dynein 1 during retinal photoreceptor development. Neural Development. 5:12

Sansam, C.L., Cruz, N.M., Danielian, P.S., Amsterdam, A., Lau, M.L., Hopkins, N., and Lees, J.A. (2010) A vertebrate gene, ticrr, is an essential checkpoint and replication regulator. Genes & Development. 24(2):183-194

Rhodes, J., Amsterdam, A., Sanda, T., Moreau, L.A., McKenna, K., Heinrichs, S., Ganem, N.J., Ho, K.W., Neuberg, D.S., Johnston, A., Ahn, Y., Kutok, J.L., Hromas, R., Wray, J., Lee, C., Murphy, C., Radke, I., Downing, J.R., Fleming, M.D., Macconaill, L.E., Amatruda, J.F., Gutierrez, A., Galinsky, I., Stone, R.M., Ross, E.A., Pellman, D.S., Kanki, J.P., and Look, A.T. (2009) Emi1 Maintains Genomic Integrity during Zebrafish Embryogenesis and Cooperates with p53 in Tumor Suppression. Molecular and cellular biology. 29(21):5911-5922

Milan, D.J., Kim, A.M., Winterfield, J.R., Jones, I.L., Pfeufer, A., Sanna, S., Arking, D.E., Amsterdam, A.H., Sabeh, K.M., Mably, J.D., Rosenbaum, D.S., Peterson, R.T., Chakravarti, A., Kääb, S., Roden, D.M., and MacRae, C.A. (2009) Drug-Sensitized Zebrafish Screen Identifies Multiple Genes, Including GINS3, as Regulators of Myocardial Repolarization. Circulation. 120(7):553-559

Slanchev, K., Carney, T.J., Stemmler, M.P., Koschorz, B., Amsterdam, A., Schwarz, H., and Hammerschmidt, M. (2009) The epithelial cell adhesion molecule EpCAM is required for epithelial morphogenesis and integrity during zebrafish epiboly and skin development. PLoS Genetics. 5(7):e1000563

Burns, C.E., Galloway, J.L., Smith, A.C., Keefe, M.D., Cashman, T.J., Paik, E.J., Mayhall, E.A., Amsterdam, A.H., and Zon, L.I. (2009) A genetic screen in zebrafish defines a hierarchical network of pathways required for hematopoietic stem cell emergence. Blood. 113(23):5776-5782

Amsterdam, A., Lai, K., Komisarczuk, A.Z., Becker, T.S., Bronson, R.T., Hopkins, N., and Lees, J.A. (2009) Zebrafish Hagoromo Mutants Up-Regulate fgf8 Postembryonically and Develop Neuroblastoma. Molecular cancer research : MCR. 7(6):841-850

Lai, K., Amsterdam, A., Farrington, S., Bronson, R.T., Hopkins, N., and Lees, J.A. (2009) Many ribosomal protein mutations are associated with growth impairment and tumor predisposition in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(1):76-85

Kishi, S., Bayliss, P.E., Uchiyama, J., Koshimizu, E., Qi, J., Nanjappa, P., Imamura, S., Islam, A., Neuberg, D., Amsterdam, A., and Roberts, T.M. (2008) The identification of zebrafish mutants showing alterations in senescence-associated biomarkers. PLoS Genetics. 4(8):e1000152

MacInnes, A.W., Amsterdam, A., Whittaker, C.A., Hopkins, N., and Lees, J.A. (2008) Loss of p53 synthesis in zebrafish tumors with ribosomal protein gene mutations. Proceedings of the National Academy of Sciences of the United States of America. 105(30):10408-10413

Carney, T.J., von der Hardt, S., Sonntag, C., Amsterdam, A., Topczewski, J., Hopkins, N., and Hammerschmidt, M. (2007) Inactivation of serine protease Matriptase1a by its inhibitor Hai1 is required for epithelial integrity of the zebrafish epidermis. Development (Cambridge, England). 134(19):3461-3471

Sivasubbu, S., Balciunas, D., Amsterdam, A.,and Ekker, S.C. (2007) Insertional mutagenesis strategies in zebrafish. Genome biology. 8(1):S9

Sansam, C.L., Shepard, J.L., Lai, K., Ianari, A., Danielian, P.S., Amsterdam, A., Hopkins, N., and Lees, J.A. (2006) DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint. Genes & Development. 20(22):3117-3129

Amsterdam, A., and Hopkins, N. (2006) Mutagenesis strategies in zebrafish for identifying genes involved in development and disease. Trends in genetics : TIG. 22(9):473-478

Nissen, R.M., Amsterdam, A., and Hopkins, N. (2006) A zebrafish screen for craniofacial mutants identifies wdr68 as a highly conserved gene required for Endothelin-1 expression. BMC Developmental Biology. 6:28

Amsterdam, A. (2006) Insertional mutagenesis in zebrafish: genes for development, genes for disease. Briefings in functional genomics & proteomics. 5(1):19-23

Amsterdam, A., and Becker, T.S. (2005) Transgenes as screening tools to probe and manipulate the zebrafish genome. Developmental Dynamics : an official publication of the American Association of Anatomists. 234(2):255-268

Amsterdam, A., Nissen, R.M., Sun, Z., Swindell, E., Farrington, S., and Hopkins, N. (2005) Submission and curation of data from an insertional mutagenesis screen. ZFIN Direct Data Submission.

Hong, J.H., Hwang, E.S., McManus, M.T., Amsterdam, A., Tian, Y., Kalmukova, R., Mueller, E., Benjamin, T., Spiegelman, B.M., Sharp, P.A., Hopkins, N., and Yaffe, M.B. (2005) TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science (New York, N.Y.). 309(5737):1074-1078

Sadler, K.C., Amsterdam, A., Soroka, C., Boyer, J., and Hopkins, N. (2005) A genetic screen in zebrafish identifies the mutants vps18, nf2 and foie gras as models of liver disease. Development (Cambridge, England). 132(15):3561-3572

Gross, J.M., Perkins, B.D., Amsterdam, A., Egana, A., Darland, T., Matsui, J.I., Sciascia, S., Hopkins, N., and Dowling, J.E. (2005) Identification of Zebrafish Insertional Mutants with Defects in Visual System Development and Function. Genetics. 170(1):245-261

Wiellette, E., Grinblat, Y., Austen, M., Hirsinger, E., Amsterdam, A., Walker, C., Westerfield, M., and Sive, H. (2004) Combined haploid and insertional mutation screen in the zebrafish. Genesis (New York, N.Y. : 2000). 40(4):231-240

Amsterdam, A., Nissen, R.M., Sun, Z., Swindell, E., Farrington, S., and Hopkins, N. (2004) Identification of 315 genes essential for early zebrafish development. Proceedings of the National Academy of Sciences of the United States of America. 101(35):12792-12797

Sun, Z., Amsterdam, A., Pazour, G.J., Cole, D.G., Miller, M.S. and Hopkins, N. (2004) A Genetic Screen in Zebrafish Identifies Cilia Genes as a Principal Cause of Cystic Kidney Development. Development (Cambridge, England). 131(16):4085-4093

Amsterdam, A., Sadler, K.C., Lai, K., Farrington, S., Bronson, R.T., Lees, J.A., and Hopkins, N. (2004) Many ribosomal protein genes are cancer genes in zebrafish. PLoS Biology. 2(5):E139

Amsterdam, A., and Hopkins, N. (2004) Retroviral-mediated insertional mutagenesis in zebrafish. The Zebrafish: Genetics, Genomics and Informatics, 2nd ed., Methods Cell Biol.. 77:3-20

Amsterdam, A. (2003) Insertional mutagenesis in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 228(3):523-534

Nissen, R.M., Yan, J., Amsterdam, A., Hopkins, N., and Burgess, S.M. (2003) Zebrafish foxi one modulates cellular responses to Fgf signaling required for the integrity of ear and jaw patterning. Development (Cambridge, England). 130(11):2543-2554

Amsterdam, A. (2003) Direct Submission of Mapping Data (Adam Amsterdam). Direct Submission of Mapping Data.

Yan, Y.-L., Miller, C.T., Nissen, R.M., Singer, A., Liu, D., Kirn, A., Draper, B., Willoughby, J., Morcos, P.A., Amsterdam, A., Chung, B.-C., Westerfield, M., Haffter, P., Hopkins, N., Kimmel, C., and Postlethwait, J.H. (2002) A zebrafish sox9 gene required for cartilage morphogenesis. Development (Cambridge, England). 129(21):5065-5079

Golling, G., Amsterdam, A., Sun, Z., Antonelli, M., Maldonado, E., Chen, W., Burgess, S., Haldi, M., Artzt, K., Farrington, S., Lin, S.Y., Nissen, R.M., and Hopkins, N. (2002) Insertional mutagenesis in zebrafish rapidly identifies genes essential for early vertebrate development. Nature Genetics. 31(2):135-140

Chen, W.B., Burgess, S., Golling, G., Amsterdam, A., and Hopkins, N. (2002) High-throughput selection of retrovirus producer cell lines leads to markedly improved efficiency of germ line-transmissible insertions in zebra fish. Journal of virology. 76(5):2192-2198

Kawakami, K., Amsterdam, A., Shimoda, N., Becker, T., Mugg, J., Shima, A., and Hopkins, N. (2000) Proviral insertions in the zebrafish hagoromo gene, encoding an F-box/WD40-repeat protein, cause stripe pattern anomalies. Current biology : CB. 10(8):463-466

Amsterdam, A., Burgess, S., Golling, G., Chen, W., Sun, Z., Townsend, K., Farrington, S., Haldi, M., and Hopkins, N. (1999) A large-scale insertional mutagenesis screen in zebrafish. Genes & Development. 13(20):2713-2724

Amsterdam, A. and Hopkins, N. (1999) Retrovirus-mediated insertional mutagenesis in zebrafish. In The Zebrafish: Genetics and Genomics, H.W. Detrich, III, M. Westerfield, and L.I. Zon, eds., San Diego, CA: Academic Press, Methods Cell Biol.. 60:87-98

Becker, T.S., Burgess, S.M., Amsterdam, A.H., Allende, M.L., and Hopkins, N. (1998) not really finished is crucial for development of the zebrafish outer retina and encodes a transcription factor highly homologous to human Nuclear Respiratory Factor-1 and avian Initiation Binding Repressor. Development (Cambridge, England). 125:4369-4378

Amsterdam, A. (1998) Use of a pseudotyped retoviral vector to accomplish insertional mutagenesis in zebrafish. Ph.D. Thesis.

Amsterdam, A., Yoon, C., Allende, M., Becker, T., Kawakami, K., Burgess, S., Gaiano, N., and Hopkins, N. (1997) Retrovirus-mediated insertional mutagenesis in zebrafish and identification of a molecular marker for embryonic germ cells. Cold Spring Harbor symposia on quantitative biology. 62:437-450

Allende, M.L., Amsterdam, A., Becker, T., Kawakami, K., Gaiano, N., and Hopkins, N. (1996) Insertional mutagenesis in zebrafish identifies two novel genes, pescadillo and dead eye, essential for embryonic development. Genes & Development. 10(24):3141-3155

Gaiano, N., Amsterdam, A., Kawakami, K., Allende, M., Becker, T., and Hopkins, N. (1996) Insertional mutagenesis and rapid cloning of essential genes in zebrafish. Nature. 383(6603):829-832

Gaiano, N., Allende, M., Amsterdam, A., Kawakami, K., and Hopkins, N. (1996) Highly efficient germ-line transmission of proviral insertions in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 93(15):7777-7782

Amsterdam, A., Lin, S., Moss, L.G., and Hopkins, N. (1996) Requirements for green fluorescent protein detection in transgenic zebrafish embryos. Gene. 173(1 Spec No):99-103

Amsterdam, A., Lin, S., and Hopkins, N. (1995) The Aequorea victoria green fluorescent protein can be used as a reporter in live zebrafish embryos. Developmental Biology. 171:123-129

NON-ZEBRAFISH PUBLICATIONS