PUBLICATION
terra is a left-right asymmetry gene required for left-right synchronization of the segmentation clock
- Authors
- Saúde, L., Lourenço, R., Gonçalves, A., and Palmeirim, I.
- ID
- ZDB-PUB-070620-2
- Date
- 2005
- Source
- Nature cell biology 7(9): 918-920 (Journal)
- Registered Authors
- Lourenço, Raquel, Saude, Leonor
- Keywords
- none
- MeSH Terms
-
- Biological Clocks/physiology
- Somites/cytology
- Somites/metabolism*
- Body Patterning/physiology*
- Chick Embryo
- Animals
- Mesoderm/metabolism
- Gene Expression Regulation, Developmental/genetics
- Embryonic Development/physiology*
- Transcription Factors/genetics
- Transcription Factors/metabolism*
- Time Factors
- Muscle, Skeletal/embryology
- Musculoskeletal Development/physiology*
- Functional Laterality/physiology*
- DNA-Binding Proteins/genetics
- DNA-Binding Proteins/metabolism
- PubMed
- 16136187 Full text @ Nat. Cell Biol.
Citation
Saúde, L., Lourenço, R., Gonçalves, A., and Palmeirim, I. (2005) terra is a left-right asymmetry gene required for left-right synchronization of the segmentation clock. Nature cell biology. 7(9):918-920.
Abstract
To establish the vertebrate body plan, it is fundamental to create left-right asymmetry in the lateral-plate mesoderm to correctly position the organs. However, it is also crucial to maintain symmetry between the left and the right sides of the presomitic mesoderm, ensuring the allocation of symmetrical body structures, such as the axial skeleton and skeletal muscles. Here, we show that terra is an early left-sided expressed gene that links left-right patterning with bilateral synchronization of the segmentation clock.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping