ZFIN ID: ZDB-PUB-070620-2
terra is a left-right asymmetry gene required for left-right synchronization of the segmentation clock
Saúde, L., Lourenço, R., Gonçalves, A., and Palmeirim, I.
Date: 2005
Source: Nature cell biology   7(9): 918-920 (Journal)
Registered Authors: Lourenço, Raquel, Saude, Leonor
Keywords: none
MeSH Terms:
  • Animals
  • Biological Clocks/physiology
  • Body Patterning/physiology*
  • Chick Embryo
  • DNA-Binding Proteins/genetics
  • DNA-Binding Proteins/metabolism
  • Embryonic Development/physiology*
  • Functional Laterality/physiology*
  • Gene Expression Regulation, Developmental/genetics
  • Mesoderm/metabolism
  • Muscle, Skeletal/embryology
  • Musculoskeletal Development/physiology*
  • Somites/cytology
  • Somites/metabolism*
  • Time Factors
  • Transcription Factors/genetics
  • Transcription Factors/metabolism*
PubMed: 16136187 Full text @ Nat. Cell Biol.
To establish the vertebrate body plan, it is fundamental to create left-right asymmetry in the lateral-plate mesoderm to correctly position the organs. However, it is also crucial to maintain symmetry between the left and the right sides of the presomitic mesoderm, ensuring the allocation of symmetrical body structures, such as the axial skeleton and skeletal muscles. Here, we show that terra is an early left-sided expressed gene that links left-right patterning with bilateral synchronization of the segmentation clock.