ZFIN ID: ZDB-PERS-070619-2
Saude, Leonor
Email: msaude@medicina.ulisboa.pt
URL: http://www.imm.fm.ul.pt/web/imm/udev
Affiliation: Leonor Saude Lab
Address: Instituto Gulbenkian de Ciencia Oeiras, 2780-156 Portugal
Country: Portugal
Phone: +351 217999498
Fax: +351 217999504

Our group is studying the molecular mechanisms that control asymmetric versus symmetric development, using the chick and the zebrafish embryos as model organisms. During embryonic development it is important to create left-right asymmetry in the lateral plate mesoderm to allow the correct positioning of the internal organs. In addition, it is fundamental to maintain symmetry between the left and the right sides of the presomitic mesoderm to ensure the perfect allocation of symmetric body structures such as the axial skeleton, skeletal muscles and peripheral nerves.

Pinto, R.A., Almeida-Santos, J., Lourenço, R., Saúde, L. (2018) Identification of Dmrt2a downstream genes during zebrafish early development using a timely controlled approach. BMC Developmental Biology. 18:14
Ribeiro, A., Monteiro, J.F., Certal, A.C., Cristovão, A.M., Saúde, L. (2017) Foxj1a is expressed in ependymal precursors, controls central canal position and is activated in new ependymal cells during regeneration in zebrafish. Open Biology. 7(11)
Azevedo, A.S., Sousa, S., Jacinto, A., and Saude, L. (2012) An amputation resets positional information to a proximal identity in the regenerating zebrafish caudal fin. BMC Developmental Biology. 12(1):24
Lourenço, R., Lopes, S.S., and Saude, L. (2010) Left-Right Function of dmrt2 Genes Is Not Conserved between Zebrafish and Mouse. PLoS One. 5(12):e14438
Lopes, S.S., Lourenço, R., Pacheco, L., Moreno, N., Kreiling, J., and Saude, L. (2010) Notch signalling regulates left-right asymmetry through ciliary length control. Development (Cambridge, England). 137(21):3625-3632
Saúde, L., Lourenço, R., Gonçalves, A., and Palmeirim, I. (2005) terra is a left-right asymmetry gene required for left-right synchronization of the segmentation clock. Nature cell biology. 7(9):918-920
Coutinho, P., Parsons, M.J., Thomas, K.A., Hirst, E.M., Saude, L., Campos, I., Williams, P.H., Stemple, D.L. (2004) Differential Requirements for COPI Transport during Vertebrate Early Development. Developmental Cell. 7(4):547-558
Feldman, B., Concha, M.L., Saude, L., Parsons, M.J., Adams, R.J., Wilson, S.W., and Stemple, D.L. (2002) Lefty antagonism of squint is essential for normal gastrulation. Current biology : CB. 12(24):2129-2135
Parsons, M.J., Pollard, S.M., Saude, L., Feldman, B., Coutinho, P., Hirst, E.M., and Stemple, D.L. (2002) Zebrafish mutants identify an essential role for laminins in notochord formation. Development (Cambridge, England). 129(13):3137-3146
Saude, L., Woolley, K., Martin, P., Driever, W., and Stemple, D.L. (2000) Axis-inducing activities and cell fates of the zebrafish organizer. Development (Cambridge, England). 127(16):3407-3417
Heisenberg, C.P., Tada, M., Rauch, G.J., Saude, L., Concha, M.L., Geisler, R., Stemple, D.L., Smith, J.C., and Wilson, S.W. (2000) Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation. Nature. 405(6782):76-81