PUBLICATION
Light reaches the very heart of the zebrafish clock
- Authors
- Carr, A.J., Tamai, T.K., Young, L.C., Ferrer, V., Dekens, M.P., and Whitmore, D.
- ID
- ZDB-PUB-060517-20
- Date
- 2006
- Source
- Chronobiology International 23(1): 91-100 (Journal)
- Registered Authors
- Dekens, Marcus P.S., Tamai, Takako Katherine, Whitmore, David
- Keywords
- Circadian Clock, Zebrafish, Entrainment, DNA Repair, Luminescent Imaging, Cell Lines
- MeSH Terms
-
- Animals
- Biological Clocks*
- Cell Cycle
- Cell Line
- Cell Lineage
- Female
- Gene Expression Regulation, Developmental
- Light*
- Male
- Mutation
- Zebrafish/embryology
- Zebrafish/physiology*
- PubMed
- 16687283 Full text @ Chronobiol. Int.
Citation
Carr, A.J., Tamai, T.K., Young, L.C., Ferrer, V., Dekens, M.P., and Whitmore, D. (2006) Light reaches the very heart of the zebrafish clock. Chronobiology International. 23(1):91-100.
Abstract
Zebrafish are typically used as a model system to study various aspects of developmental biology, largely as a consequence of their ex vivo development, high degree of transparency, and, of course, ability to perform forward genetic mutant screens. More recently, zebrafish have been developed as a model system with which to study circadian clocks. Cell lines generated from early-stage zebrafish embryos contain clocks that are directly light-responsive. We describe recent experiments using single-cell luminescent imaging approaches to study clock function in this novel cell line system. Furthermore, studies examining the process of entrainment to light pulses within this cell population are described in this review, as are experiments examining light-responsiveness of early-stage zebrafish embryos.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping