PUBLICATION
The zebrafish: a new model of T-cell and thymic development
- Authors
- Langenau, D.M., and Zon, L.I.
- ID
- ZDB-PUB-050404-10
- Date
- 2005
- Source
- Nature reviews. Immunology 5(4): 307-17 (Review)
- Registered Authors
- Langenau, David, Zon, Leonard I.
- Keywords
- none
- MeSH Terms
-
- Animals
- Animals, Genetically Modified
- Cell Differentiation/immunology
- Genes, Reporter
- Models, Animal*
- Mutation
- T-Lymphocytes/cytology
- T-Lymphocytes/immunology*
- Thymus Gland/cytology
- Thymus Gland/embryology*
- Thymus Gland/immunology*
- Zebrafish*/embryology
- Zebrafish*/genetics
- Zebrafish*/immunology
- PubMed
- 15803150 Full text @ Nat. Rev. Immunol.
Citation
Langenau, D.M., and Zon, L.I. (2005) The zebrafish: a new model of T-cell and thymic development. Nature reviews. Immunology. 5(4):307-17.
Abstract
T-cell and thymic development are processes that have been highly conserved throughout vertebrate evolution. Mammals, birds, reptiles and fish share common molecular signalling pathways that regulate the development of the adaptive immune system. This Review article focuses on defining the similarities and differences between zebrafish and mammalian T-cell immunobiology, and it highlights the advantages of using the zebrafish as a genetic model to uncover mutations that affect T-cell and thymic development. Finally, we summarize the use of the zebrafish as a new model for assessing stem-cell function and for drug discovery.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping