ZFIN ID: ZDB-PUB-050404-10
The zebrafish: a new model of T-cell and thymic development
Langenau, D.M., and Zon, L.I.
Date: 2005
Source: Nature reviews. Immunology   5(4): 307-17 (Review)
Registered Authors: Langenau, David, Zon, Leonard I.
Keywords: none
MeSH Terms:
  • Animals
  • Animals, Genetically Modified
  • Cell Differentiation/immunology
  • Genes, Reporter
  • Models, Animal*
  • Mutation
  • T-Lymphocytes/cytology
  • T-Lymphocytes/immunology*
  • Thymus Gland/cytology
  • Thymus Gland/embryology*
  • Thymus Gland/immunology*
  • Zebrafish*/embryology
  • Zebrafish*/genetics
  • Zebrafish*/immunology
PubMed: 15803150 Full text @ Nat. Rev. Immunol.
T-cell and thymic development are processes that have been highly conserved throughout vertebrate evolution. Mammals, birds, reptiles and fish share common molecular signalling pathways that regulate the development of the adaptive immune system. This Review article focuses on defining the similarities and differences between zebrafish and mammalian T-cell immunobiology, and it highlights the advantages of using the zebrafish as a genetic model to uncover mutations that affect T-cell and thymic development. Finally, we summarize the use of the zebrafish as a new model for assessing stem-cell function and for drug discovery.